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| 1 | Neuroendocrine and squamous colonic composite carcinoma:Case report with molecular analysis显示文摘Composite colorectal carcinomas are rare. There are amodest number of cases in the medical literature,with even fewer cases describing composite carcinoma with neuroendocrine and squamous components. There areto our knowledge no reports of composite carcinomamolecular alterations. We present a case of composite carcinoma of the splenic flexure in a 33 year-old Cau-casian male to investigate the presence and prognos-tic significance of molecular alterations in rare coloniccarcinoma subtypes. Formalin-fixed paraffin-embedded(FFPE) tissue was hematoxylin and eosin- and mucicar-mine-stained according to protocol,and immuno-stained with cytokeratin(CK) 7,CK20,CDX2,AE1/AE3,chromo-granin-A and synaptophysin. DNA was extracted from FFPE tissues and molecular analyses were performed according to lab-developed methods,followed by capil-lary electrophoresis. Hematoxylin and eosin staining showed admixed neuroendocrine and keratinized squamous cells. Positive nuclear CDX2 expression confirme dintestinal derivation. CK7 and CK20 were negative.Neuroendocrine cells stained positively for synaptophysin and AE1/AE3 and negatively for chromogranin and mucicarmine. Hepatic metastases showed a similar immunohistochemical profile. Molecular analysis revealeda G13D KRAS mutation. BRAF mutational testing wasnegative and microsatellite instability was not detected.The patient had rapid disease progression on chemotherapy and died 60 d after presentation. Although theG13D KRAS mutation normally predicts an intermed iateoutcome,the aggressive tumor behavior suggests other modifying factors in rare types of colonic carcinomas. | Sabrina C Wentz Cindy Vnencak-Jones William V Chopp | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 2 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 3 | Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status:relation to cellular and integrated electrophysiology显示文摘 | Sabrina LB Sophie D Arnaud C | 2003 | Circ Res2003，92，2： | 1 |
| 4 | CMOS active pixel image sensors for highly integrated imaging systems 显示文摘 | SUNETRA K M SABRINA E K RUSSELL C G | 1997 | IEEE Journal of Solidstate Circuits1997，32，2： | 1 |
| 5 | Tyrosine pbosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells显示文摘 | Vinicio C Massimo P Sabrina G | 2000 | Hepatol2000，31，1： | 1 |
| 6 | 显示文摘 | Franck D Gregorio C Sabrina B | 2005 | Carbohydrate Poly- mers2005，60，1： | 1 |
| 7 | Barrett's esophagus:an update显示文摘 | Massimo C Gabriella L Sabrina B | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 8 | Polycyclic aromatic hydrocarbons in vegetable oils from canned foods 显示文摘 | SABRINA M GIORGIA P LANFRANCO S C | 2005 | Eur J Lipid Sci Tech2005，107，： | 1 |
| 9 | CMOS Active Pixel Image Sensors for Highly Integrated Imaging Systems显示文摘 | Sunetra K Mendis Sabrina E Kemeny Russell C Gee | 1997 | Journal of Solid-State Circuits1997，32，2： | 1 |
| 10 | miR-204 is required for lens and retinal development via Meis2 targeting 显示文摘 | Ivan C Sabrina C Raffaella A | 2010 | Proceedings of the National Academy of Sciences2010，107，15： | 1 |
| 11 | Evaluation of the spoilage potential of bacteria isolated fi'om spoiled cooked whole tropical shrimp (Penaeus vannamei) stored under modified atmosphere packaging 显示文摘 | Sabrina M Mireille C Emmanuel J | 2014 | Food Microbiology2014，40，： | 1 |
| 12 | Occurrence and spatial and temporal variations of disinfection by-products in the water and air of two indoor swimming pools 显示文摘 | CATTO C SABRINA S GINETTE CT | 2012 | Inter J Env Res Pub Heal2012，9，8： | 1 |
| 13 | Poly(ethylene terephthalate)(PET)degradation during the Zn catalyzed transesterification with dibutyl maleate functionalized polyolefins显示文摘 | MARIA-BEATRICE C SABRINA B MAURO A | 2007 | Polymer2007，48，5： | 1 |
| 14 | Managing and Sharing Servents' Reputations in P2P Systems显示文摘 | Ernesto D Sabrina D C Stefano P | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，4： | 1 |
| 15 | Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells显示文摘 | SABRINA C SILVIA M SARA M | 2011 | PNAS2011，42，17： | 1 |
| 16 | Advantages and issues of concern regarding approaches to peripheral nerve block for total hip arthroplasty显示文摘In older patients with comorbidities,hip fractures are both an important and debilitating condition.Since multimodal and multidisciplinary perioperative strategies can hasten functional recovery after surgery improving clinical outcomes,the choice of the most effective and safest pathway represents a great challenge.A key point of concern is the anesthetic approach and above all the choice of the locoregional anesthesia combined with general or neuraxial anesthesia. | Marco Crisci Arturo Cuomo Cira Antonietta Forte Sabrina Bimonte Gennaro Esposito Maura C Tracey Marco Cascella | 2021 | World Journal of Clinical Cases2021，9，36： | 1 |
| 17 | Preparation, characterization and sorption properties of cross-linked starchbased exchanger显示文摘 | Franck D Gregorio C Sabrina B | 2005 | Carbohydrate Polymers2005，，60： | 1 |
| 18 | CMOS active pixel image sensor for highly integrated imaging system显示文摘 | Sunetra K Mendis Sabrina E Kemeny Russell C Gee | 1997 | IEEE Journal of Solid-State Circuits1997，32，2： | 1 |
| 19 | Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein(TSPO)ligands as antiproliferative agents in human glioblastoma tumors显示文摘 | Sabrina C Sabrina T Monica V | 2014 | J Med Chem2014，57，6： | 1 |
| 20 | mRNA detection by reverse transcription-PCR for monitoring viability over time in an Enterococcus faecalis viable but nonculturable population maintained in a laboratory microcosm显示文摘 | Maria M L Sabrina P Maria C T | 2000 | Applied and Environmental Microbiology2000，66，10： | 1 |
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