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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | Gastric intestinal metaplas a: subtypes and natural history 显示文摘 | El-Zimaitv H M Ramchatesingh J Saeed M A | 2001 | J Clin Pathol2001，54，9： | 1 |
| 3 | Feature selection based on class-dependent densities for high-dimensional bi-nary data显示文摘 | JAVED K BABRI H A SAEED M | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，3： | 1 |
| 4 | Comparative study of physical activity of hypertensives and uormotensives : a cross- sectional study of adults in Saudi Arlbia 显示文摘 | AL-HAMDAN N A AL-ZALABANI A H SAEED A A | 2012 | J Fam Commun Med2012，19，3： | 1 |
| 5 | Neutronscattering studies of the structure of highly tetrahedral amorphous diamondlike carbon显示文摘 | GASKELL P H SAEED A CHIEUX P | 1991 | Phys Rev Lett1991，67，10： | 1 |
| 6 | Improved production of Pseudomonas aeruginosa uricase by optimization of process parameters through statistical experimental designs 显示文摘 | Abdel-Fattah Y R Saeed H M Gohar Y M | 2005 | Process Biochemistry2005，40，： | 1 |
| 7 | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation显示文摘 | Saeed SA Rasheed H | 2003 | Acta Pharmacol Sin2003，24，： | 1 |
| 8 | A study on chemical properties of groundwater and soil in ophiolitic rocks in Firuzard,east of Shahrood,Iran:With emphasis to heavy metal contamination显示文摘 | Hajizardeh N Ghol H K Saeed S | 2011 | Environmental Monitoring and Assessment2011，174，14： | 1 |
| 9 | Orbital irradiation for Graves' ophthalmopathy: Is it safe? A long-term follow-up study 显示文摘 | Wakelkamp IM Tan H Saeed P | 2004 | Ophthalmology2004，111，8： | 1 |
| 10 | Hybrid adaptive fuzzy identification and control of nonlinear systems 显示文摘 | MEHRDAD H SAEED G | 2002 | IEEE Transactions on Fuzzy Sys- tems2002，10，2： | 1 |
| 11 | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation 显示文摘 | SAEED SA RASHEED H | 2003 | Acta Pharmacol Sin2003，24，1： | 1 |
| 12 | Association of Gprotein beta-3 subunit gene ( GNB3 ) T825 allele with Type Ⅱ diabetes显示文摘 | KIANI J G SAEED M PARVEZ S H | 2005 | Neuro Endocrinol Lett2005，26，2： | 1 |
| 13 | Papillomaviruslike particles are an effective platform for amyloid-β immunization in rabbits and transgenic mice显示文摘 | Eduardo Z Alessandra H Saeed SK | | 0，，04： | 1 |
| 14 | Effect of glass slope angle and water depth on productivity of double slope solar stili显示文摘 | Al - Garni A Z Kassem A H Saeed F | 2011 | Journal of Scientific and Industrial Research2011，70，： | 1 |
| 15 | Effect of different host plants on the fitness of diamond-back moth, PluteUa xylostella (Lepidoptem: Plutellidae)显示文摘 | SAEED R SAYYED A H SHAD S A | 2010 | Crop Protection2010，，29： | 1 |
| 16 | Osteoblastic cells:differentiation and trans-differentiation显示文摘 | Kassem M Abdallah BM Saeed H | | 0，，： | 1 |
| 17 | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation显示文摘 | Saeed S A Rasheed H | 2003 | Acta Pharmacd Sin2003，24，1： | 1 |
| 18 | Potential of partial root- zone drying as an alternative irrigation technique for potatoes( Solarium tuberosum) 显示文摘 | Saeed H Grove I G Kettlewell P S | 2008 | Annals of Applied Biology2008，152，1： | 1 |
| 19 | Death receptor activation complex: it takes two to active TNF receptor 1显示文摘 | M Saeed S Ying H | 2003 | Cell Cycle2003，2，6： | 1 |
| 20 | Fatigue crack growth and life prediction of a single interference letted holed plate 显示文摘 | Chakherlou T N Mirzajanzadeh M Saeed K H | 2010 | Fatigue &Fracture of Engineering Materials&Structures2010，33，10： | 1 |
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