|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Determinants of liver damage associated with intravenous methylprednisolone pulse therapy in Graves' ophthalmopathy 显示文摘 | Le Moli R Baldeschi L Saeed P | 2007 | Thyroid2007，17，4： | 1 |
| 3 | A closer look at food allergy and in tolerance显示文摘 | Ali R Ali SS | 2004 | J Coll Physicians Surg Pak2004，14，6： | 1 |
| 4 | Improved production of Pseudomonas aeruginosa uricase by optimization of process parameters through statistical experimental designs 显示文摘 | Abdel-Fattah Y R Saeed H M Gohar Y M | 2005 | Process Biochemistry2005，40，： | 1 |
| 5 | A closer look at food allergy and intol- erance显示文摘 | Saeed SA Ali R Ali SS | 2004 | J Coil Physicians Surg Pak2004，14，6： | 1 |
| 6 | Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo 显示文摘 | Hartlapp I Abe R Saeed RW | 2001 | Faseb J2001，15，12： | 1 |
| 7 | Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site 显示文摘 | OSTANIN K SAEED A VAN ETTEN R L | 1994 | Journal of Biological Chemistry1994，269，12： | 1 |
| 8 | Complications following adult cochlear implantation: experience in Manchester显示文摘 | GREEN K M BHATT Y M SAEED S R | 2004 | J Laryngol Otol2004，118，： | 1 |
| 9 | Enhancement of propylene production in a downer FCC operation using a ZSM-5 additive显示文摘 | ABUL-HAMAYEL M A AITANI A M SAEED M R | 2005 | Chem Eng Technol2005，28，8： | 1 |
| 10 | Eugenol:a dual inhibitor of platelet-activating factor and arachidonic acid metabolism显示文摘 | Saeed S A Simjee R U Shamim G | 1995 | Phytomedicine1995，2，1： | 1 |
| 11 | Synthesis and characterization of new optically active and photolable poly(amide-imide)s from N,N'-(3,3',4,4'-benzophenonetetra-carboxylic)-3,3',4,4'-diimido-di-L-methionine and different diamines显示文摘 | Abdol R Hajipour Saeed Zahmatkesh Arnold E Ruoho | 2006 | Polymer Bulletin2006，57，： | 1 |
| 12 | A mild and chemoselective catalyst for thioacetalization under solvent-free conditions显示文摘 | Abdol R Hajipour Saeed Zahmatkesh Arnold E Ruoho | | 0，，： | 1 |
| 13 | Effect of different host plants on the fitness of diamond-back moth, PluteUa xylostella (Lepidoptem: Plutellidae)显示文摘 | SAEED R SAYYED A H SHAD S A | 2010 | Crop Protection2010，，29： | 1 |
| 14 | Peripartum hysterectomy : aten-year experience at a tertiary care hospital in a developingcountry显示文摘 | Saeed F Khalid R AKhan R | 2010 | Tropical Doctor2010，40，： | 1 |
| 15 | Synthesis and characterization of novel optically active poly (amide–imide) s via direct amidation显示文摘 | Abdol R Hajipour Saeed Zahmatkesh Ahmad Banihashemi | | 0，，： | 1 |
| 16 | A closer look at food allergy and in- tolerance显示文摘 | Saeed SA Ali R Ali SS | 2004 | J Coll Physicians Surg Pak2004，14，6： | 1 |
| 17 | Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site显示文摘 | Ostanin K Saeed A Van Etten R L | 1994 | J Biol Chem1994，269，12： | 1 |
| 18 | An investigation on effects of heat treatment on corrosion properties of Ni-P electroless nano coatings 显示文摘 | TAHER R SAEED R A ARMAN Z | 2010 | Mater Design2010，31，： | 1 |
| 19 | Recurrent carpal tunnel syndrome in a child due to fibrolipomatous hamartoma of the median nerve successfully treated by limited excision and decompression显示文摘 | Bains R Kotwal A Saeed W | 2006 | J Plast Reconstr Aesthet Surg2006，59，12： | 1 |
| 20 | Novel,rapid assay for measuring entry of diverse enveloped viruses,including HIV and rabies显示文摘 | Saeed M F Kolokoltsov A A Davey R A | 2006 | J Virol Methods2006，135，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员