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| 1 | Parameters affecting the harmonic distortion in a convener station显示文摘 | Christoforidis G P Sakis Meliopoulos A P | 1991 | IEEE Trans on PWRD1991，6，4： | 1 |
| 2 | The study of developmental capacity of vitrified mouse blastocysts in different straws after transfer to mouse pseudo pregnant显示文摘 | Saki G Rahim F Moradi L | 2008 | Pak J Biol Sci2008，11，14： | 1 |
| 3 | Analysis of DC grounding systems显示文摘 | Sakis M A P Cokkinides G J Dunlap J | 1988 | IEEE Trans on Power Delivery1988，3，4： | 1 |
| 4 | The study of developmental capacity of vitrified mouse blastocysts in different straws after transfer to mouse pseudo pregnant显示文摘 | Saki G Rabim F Moradi L | 2008 | Pak J Biol Sci2008，11，14： | 1 |
| 5 | Anatomical variations of neurovascular structures adjacent sphenoid sinus by using CT scan显示文摘 | Davoodi M Saki N Saki G | | 0，，06： | 1 |
| 6 | Total phenols, antioxidant potentialand tyrosinase inhibitory activity of walnut (Juglans regiaL) leaf, husk and seed显示文摘 | AKIN M A G SAKI N | 2013 | Asian Journal of Chemistry2013，25，16： | 1 |
| 7 | Follicular dynamics inneonate vitrified ovarian grafts after host treatment withmelatonin显示文摘 | Hemadi M Saki G Shokri S | 2011 | Folia Morphol(Warsz)2011，70，1： | 1 |
| 8 | The study of developmental capacity of vitrified mouse blastocysts in different straws after transfer to Mouse pseudo pregnant 显示文摘 | Saki G Rahim F Moradi L | 2008 | Pak J Biol Sci2008，11，14： | 1 |
| 9 | Follicular dynamics in neonate vitrified ovarian grafts after host treatment with melatonin 显示文摘 | Hemadi M Saki G Shokri S Ghasemi F | 2011 | Folia Morphol2011，70，1： | 1 |
| 10 | The study of developmental capacity of vitrified mouse blastocysts in different straws after transfer to mouse pseudo pregnant显示文摘 | Saki G Rahim F Moradi L | 2008 | Pak J Biol 8ci2008，11，14： | 1 |
| 11 | Anatomical variations ofneurovascular structures adjacent sphenoid sinus by using CT scan 显示文摘 | Davoodi M Saki N Said G | 2009 | Pak J Biol Sci2009，12，6： | 1 |
| 12 | The study of developmental capacity of vitrified mouse blastoeysts in different straws after transfer to mouse pseudo pregnant显示文摘 | Saki G | 2008 | Jul 152008，11，14： | 1 |
| 13 | Melatonin and tes- ticular damage in busulfan treated mice显示文摘 | MIRHOSEINI M SAKI G HEMADI M | 2014 | Iran Red Crescent Med J2014，16，14： | 1 |
| 14 | Melatonin improves spermatogoniai stem cells transplantation efficiency in azoospermic mice显示文摘 | GHOLAMI M SAKI G HEMADI M | 2014 | Iran J Basic Med Sci2014，17，2： | 1 |
| 15 | Comparison of SS-GIC and MHD-EMP-GIC effects on power systems显示文摘 | Sakis Melioponlos A P Glytsis E S Cokkinides G J | 1994 | IEEE Transaction on Power Delivery1994，9，1： | 1 |
| 16 | Follicular dynamics in neonate vitrified ovarian grafts after host treatment with melatonin显示文摘 | Hemadi M Saki G Shokri S | 2011 | Folia Morphol2011，70，1： | 1 |
| 17 | Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects显示文摘OBJECTIVE Over 30% of all new psychoactive substances identified by the UN Office on Drugs and Crime in 2016 were synthetic cannabinoids.The recent emergence of MAM-2201 on the illicit market is troubling because this drug has no precedent in either the scientific or patent literature,and appears to be a novel compound developed specifically as a 'graymarket' drug of abuse bystructurally combining the known synthetic cannabinoids JWH-122 and AM-2201.There is currently no published information regarding the pharmacology of MAM-2201.METHODS The present studies characterized cannabinoid-like effects of MAM-2201 in vitro(interactions with cannabinoid type 1 receptors[CB1 Rs]) and in vivo(in mice and rats).RESULTS In a radioligand binding assay using [3 H]CP55,940 in HEK cell membranes transfected with the CB1 R,MAM-2201(K i=5.4 nmol·L^(-1)),had higher binding affinity than WIN 55,212-2(K i=80 nmol·L^(-1)),and D9-THC(K i=8.3 nmol·L^(-1)).The E max values for MAM-2201 and WIN 55,212-2 in an assay of agonist inhibition of forskolin-stimulated c AMP were 85%(EC50=0.45 nmol·L^(-1)) and 95%,respectively,as compared with the D9-THC E max of 74%.In mice,MAM-2201(0.003-1.0 mg·kg^(-1),IP) produced dose-dependent cannabimimetic effects which were both more potent and more effective than those of D9-THC.MAM-2201 and D9-THC dose-dependently produced hypothermia:ED50=0.287 and 25.4 mg·kg^(-1),analgesia:ED50=0.125 and 29.4 mg·kg^(-1),and catalepsy:ED50=0.301 and18.9 mg·kg^(-1) in adult male CD1 mice.Importantly,MAM-2201 also elicited convulsant effects at a dose of 1.0 mg·kg^(-1) in 8/8 murine subjects.In rats,MAM-2201 produced dose-dependent D9-THC-like interoceptive effects in subjects trained to discriminate 3.0 mg·kg^(-1)(IP) D9-THC from saline.CONCLUSION MAM-2201 binds CB1 Rs with high affinity and agonist efficacy,and functions as a potent cannabinoid agonist in vivo across several complementary measures of cannabinoid activity in two rodent species. | William E FANTEGROSSI Aaron JANOWSKY Amy J ESHLEMAN Lauren N RUSSELL Saki FUKUDA Jyoti GOGOI Cassandra PRIOLEAU Ambuja S BALE Srihari R TELLA Merle G PAULE Takato HIRANITA | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
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