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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | 中医药在巴西的发展现状与分析显示文摘巴西医疗保险以统一医疗体系(Unified Health System,SUS)的免费医疗为主、私人保险为补充,已实现全民享有基本医疗服务。导致该国居民死亡的主要疾病是缺血性心脏病、脑卒中、下呼吸道感染,近年来AD、慢性肾脏病及糖尿病的发病率显著增高。以针灸为代表的中医疗法在19世纪初传入巴西,目前针灸治疗已得到较广泛的认可和应用,被纳入SUS,并在多所高校开设相关课程,但中医药整体特色有待加强,从业人员对中药的理解、运用不足,以及中医药教育缺乏规范等问题限制了中医药在巴西的发展。建议通过发挥中医药治未病的特色,加大中药研发力度并扩大市场,规范中医教育等措施,促进两国在中医药领域的广泛合作,推动中医药在巴西的发展与传播。 | 李皓月 党迎迎 Thaís Salles Araujo Fatima Terezinha Pelachini Farias Jaime Amador Soares Graciela Mendonça da Silva de Medeiros 于涛 魏竞竞 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，5： | 5 |
| 3 | Review of wind turbine control显示文摘 | De La Salle S A | 1990 | Int JControl1990，52，6： | 2 |
| 4 | Molecular imaging of movement disorders显示文摘Positron emission tomography measures the activity of radioactively labeled compounds which distribute and accumulate in central nervous system regions in proportion to their metabolic rate or blood flow. Specific circuits such as the dopaminergic nigrostriatal projection can be studied with ligands that bind to the pre-synaptic dopamine transporter or post-synaptic dopamine receptors(D1 and D2). Single photon emission computerized tomography(SPECT) measures the activity of similar tracers labeled with heavy radioactive species such as technetium and iodine. In essential tremor, there is cerebellar hypermetabolism and abnormal GABAergic function in premotor cortices, dentate nuclei and ventral thalami, without significant abnormalities in dopaminergic transmission. In Huntington's disease, there is hypometabolism in the striatum, frontal and temporal cortices. Disease progression is accompanied by reduction in striatal D1 and D2 binding that correlates with trinucleotide repeat length, disease duration and severity. In dystonia, there is hypermetabolism in the basal ganglia, supplementary motor areas and cerebellum at rest. Thalamic and cerebellar hypermetabolism is seen during dystonic movements, which can be modulated by globus pallidus deep brain stimulation(DBS). Additionally, GABA-A receptor activity is reduced in motor, premotor and somatosensory cortices. In Tourette's syndrome, there is hypermetabolism in premotor and sensorimotor cortices, as well as hypometabolism in the striatum, thalamus and limbic regions at rest. During tics, multiple areas related to cognitive, sensory and motor functions become hypermetabolic. Also, there is abnormal serotoninergic transmission in prefrontal cortices and bilateral thalami, as well as hyperactivity in the striatal dopaminergic system which can be modulated with thalamic DBS. In Parkinson's disease(PD), there is asymmetric progressive decline in striatal dopaminergic tracer accumulation, which follows a caudal-to-rostral direction. Uptake declines prior to symptom presentation and progresses from contralateral to the most symptomatic side to bilateral, correlating with symptom severity. In progressive supranuclear palsy(PSP) and multiple system atrophy(MSA), striatal activity is symmetrically and diffusely decreased. The caudal-to-rostral pattern is lost in PSP, but could be present in MSA. In corticobasal degeneration(CBD), there is asymmetric, diffuse reduction of striatal activity, contralateral to the most symptomatic side. Additionally, there is hypometabolism in contralateral parietooccipital and frontal cortices in PD; bilateral putamen and cerebellum in MSA; caudate, thalamus, midbrain, mesial frontal and prefrontal cortices in PSP; and contralateral cortices in CBD. Finally, cardiac sympathetic SPECT signal is decreased in PD. The capacity of molecular imaging to provide in vivo time courses of gene expression, protein synthesis, receptor and transporter binding, could facilitate the development and evaluation of novel medical, surgical and genetic therapies in movement disorders. | Karlo J Lizarraga Alessandra Gorgulho Wei Chen Antonio A De Salles | 2016 | World Journal of Radiology2016，8，3： | 2 |
| 5 | Carbon stocks in Senegal's Sahel Transition Zone显示文摘 | Woomer P L Toure A Sall M | 2004 | Journal of Arid Environments2004，59，： | 1 |
| 6 | Strategies and Metric for Resili- ence in Computer Networks 显示文摘 | Salles R M Marino D A J R | 2011 | The Computer Journal Ad- vance Access published2011，2011，： | 1 |
| 7 | Species composition and population dynamics of leafminer flies and their parasitoids in Victoria显示文摘 | BJORKSTEN T A ROBINSON M SALLE J L | 2005 | Australian Journal of Entomology2005，44，： | 1 |
| 8 | The SAPHO syndrome: a clinical and imaging study 显示文摘 | Salles M Olive A Perez - Andres R | 2011 | ClinRheumatol2011，30，2： | 1 |
| 9 | Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E(Fc epsilon RI)显示文摘 | de la Salle H Wollenberg A | 1992 | J Exp Med1992，175，： | 1 |
| 10 | Gastric MALT Lymphoma presenting as Waldenstrom's macroglobulinemia without bone marrow involvement显示文摘 | Salle V Smail A Joly JP | 2007 | Clin Lymphoma Myeloma2007，7，7： | 1 |
| 11 | Perinatal metabolism of vitamin D 显示文摘 | SALLE B L DELVIN E E LAPILLONNE A | 2000 | Am J Clin Nutr2000，71，5： | 1 |
| 12 | Helicobacter pylori infection in geriatrics显示文摘 | Pilotto A Salles N | 2002 | Helicobacter2002，71，： | 1 |
| 13 | Course of ionized calcium after thyroidectomy 显示文摘 | de Andrade Sousa A Salles JM Soares JM | 2010 | World J Surg2010，34，5： | 1 |
| 14 | Experimental investigation of the dynamics of entanglement :Sudden death,Complementarity, and contnous monitoring of the envinorment 显示文摘 | SALLES A MELO F ALMEIDA M P | 2008 | Phys Rev A2008，，02： | 1 |
| 15 | Human disc phospholipase A2 is inlammatory显示文摘 | Eranson R Sall J Sall J A | 1992 | Spine1992，17，6： | 1 |
| 16 | Performance and immune response of suckling calves fed organic selenium显示文摘 | Salles M S V Zanetti M A Junior L C R | 2014 | Anim Feed Sci Technol2014，188，： | 1 |
| 17 | CT of pancreas: minimum intensity projections显示文摘 | Salles A Nino-Murcia M Jeffrey R B Jr | 2008 | Abdom Imaging2008，33，2： | 1 |
| 18 | Relevance of an electrochemical process prior to a biological treatment for the removal of an organophosphorous pesticide,phosmet显示文摘 | SALLES N A FOURCADE F GENESTE F | 2010 | Journal of Hazardous Materials2010，181，1： | 1 |
| 19 | Bone mineralization and growth are enhanced in preterm infants fed an isocaloric, nutrient- enriched preterm formula through term显示文摘 | Lapillonne A Salle B L Glorieux F H | 2004 | The American Journal of Clinical Nutrition2004，80，6： | 1 |
| 20 | Evolution and phylogenetic infor-mation content of the ITS-1 region in the tiger beetle Ci-cindela dorsalis显示文摘 | Vogler A P De Salle R | 1994 | Molecular Biology and Evolution1994，11，3： | 1 |
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