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| 1 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Action of costal and crural parts of the diaphragm on the rib cage in dog显示文摘 | De Troyer A Sampson M Sigrist S | 1982 | J Appl Physiol1982，53，1： | 1 |
| 4 | An operational statisti- cal typhoon intensity prediction scheme for the western north paeifie显示文摘 | Knaff J A Sampson C R DeMaria M | 2005 | Wea Forecasting2005，20，： | 1 |
| 5 | A successive approximation vector quantizer for wavelet transform image coding显示文摘 | da Silva E A B Sampson D G Ghanbari M | 1997 | IEEE Trans on Image Processing1997，5，2： | 1 |
| 6 | Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease显示文摘 | Sampson U K Dorbala S Limaye A Kwong R Di Carli M F | 2007 | J Am Coll Cardiol2007，49，： | 1 |
| 7 | Investigation of the attachment of Thiobacillus ferrooxidans to mineral sulfides using scanning elctron microscopy analysis显示文摘 | SAMPSON M L PHILIPS C V BALL A S | 2000 | Minerals Engineering2000，13，： | 1 |
| 8 | The anti-inflammatory effects of leukotriene-modifying drugs and their uses in astham 显示文摘 | Saivi S S Krishna M T Sampson A P | 2001 | Chest2001，119，5： | 1 |
| 9 | Effects of combined angiotensin II and endothelin receptor blockade with developing heart failure: effects on left ventricular performance显示文摘 | New R B Sampson A C King M K | 2000 | Circulat:ion2000，102，12： | 1 |
| 10 | The Anti-inflammatory Effects of Leukotriene-modifying Drugs and Their use in Asthma显示文摘 | Salvi S S Krishna M T Sampson A P | 2001 | Chest2001，119，5： | 1 |
| 11 | The diaphragm : two muscles 显示文摘 | DeTroyer A Sampson M Sigrist S | 1981 | Science1981，213，4504： | 1 |
| 12 | Action of costal and crual parts of the diaphragm on the rib cage in dog 显示文摘 | DeTroyer A Sampson M Sigrist S | 1982 | J Appl Physiol Respir Environ Exercphysiol1982，53，1： | 1 |
| 13 | Postnatal ontogeny of angiotensin receptors and ACE2 in male and female rats显示文摘 | SAMPSON A K MORITZ K M DENTON K M | 2012 | Gend Med2012，9，1： | 1 |
| 14 | Linking organic matter deposition and iron mineral transformations to ground- water arsenic levels in the Mekong delta, Cambodia显示文摘 | Quicksall A N Bostick B C Sampson M L | 2008 | Ap- plied Geochemistry2008，23，： | 1 |
| 15 | An operational statistical typhoon intensity prediction scheme for the western North Pacific显示文摘 | KNAFF J A SAMPSON C R DEMARIA M | 2005 | Wea Forecasting2005，20，4： | 1 |
| 16 | Effect of anti-IgE therapy in patients with peanut allergy显示文摘 | Sampson H A Yunginger J W | 2003 | N Engl J Med2003，348，： | 1 |
| 17 | Effect of anti- IgE therapy in patients with peanut allergy 显示文摘 | Leung Y M D Sampson H A Yunginge J W | 2003 | N Engl J Med2003，348，11： | 1 |
| 18 | Moving boundary shallow water flow above parabolic bottom topography 显示文摘 | SAMPSON J EASTON A SINGH M | 2006 | ANZIAM Journal2006，47，2005： | 1 |
| 19 | The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man显示文摘 | Orban Z Remaley A sampson M | 1999 | J Clin Endocrinol Metab1999，84，6： | 1 |
| 20 | Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey : a 5- year follow- up study 显示文摘 | Sicherer S H Furlong A M Sampson H A | 2003 | The Journal of Allergy and Clinical Immunology2003，112，6： | 1 |
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