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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Effect of magnesium content on the ageing behaviour of water-chilled Al-Si-Cu-Mg-Fe- Mn (380) alloy castings 显示文摘 | SAMUEL F H SAMUEL A M LIU H | 1995 | Journal of Materials Science1995，30，： | 1 |
| 3 | Randomized trial of postoperative adjuvant chemotherapy with or without radiother- apy for Ccareinoma of the rectum : National Surgical Adjuvant Breast and Bowel Project Protocol R -02 显示文摘 | Norman Wolmark Samuel Wieand H Hyams D M | 2000 | Journal of the National Cancer Institute2000，92，5： | 1 |
| 4 | Influence of Tin Addition on the Microstructure and Mechanical Properties of Al-Si-Cu-Mg and Al-Mg-Si Casting Alloys显示文摘 | Mohamed A M A Samuel G H | 2008 | Metallurgical and materials transactions A2008，39，： | 1 |
| 5 | Effects of solifenacin on overactive bladder symptoms, symptom bother and other patient-reported outcomes: results from VIBRANT-a double-blind, placebo-controlled trial显示文摘 | Vardy M D Miteheson H D Samuels T A | 2009 | Int J Clin Pract2009，63，12： | 1 |
| 6 | Characteristics of a- dendritic and eutectic structures in St-treated A1-Si casting alloys显示文摘 | Liu L Samuel A M Samuel F H | 2004 | Journal of Materials Science2004，39，： | 1 |
| 7 | Effect of solution heat treatment and additives on the microstructure of Al-Si automotive alloys显示文摘 | MOUSTAFA M A SAMUEL F H DOTY H W | 2004 | Materials Science Forum2004，，1： | 1 |
| 8 | Various aspects involved in the production of low-hydrogen aluminium castings 显示文摘 | Samuel A M Samuel F H | 1992 | Journal of Materials Science1992，27，： | 1 |
| 9 | Sr-Nd-Pb isotope and trace element systematics of mantle xenoliths from Late Cenozoic alkaline lavas,South Korea显示文摘 | Sung H C Sung-Tack K Samuel B M Hee S | | 0，，： | 1 |
| 10 | Optimizing the tensileproperties of Al-Si-Cu-Mg 319-type alloys: Roie of solution heattreatmcnt显示文摘 | HAN Y SAMUEL A M DOTY H W | 2014 | Materials and Design2014，58，6： | 1 |
| 11 | Precipitation-hardening in cast Al-Si-Cu-Mg alloys显示文摘 | TAVITAS M F J MOHAMED A M A GRUZLESKI J E SAMUEL F H DOTY H W | 2010 | Journal of Material Science2010，45，3： | 1 |
| 12 | A study of tensile properties in A1-Si-Cu and A1-Si-Mg alloys: Effect of/3-iron intermetallics and porosity显示文摘 | MA Z SAMUEL A M SAMUEL F H DOTY H W VALTIERRA S | 2008 | Materials Science and Engineering A2008，490，12： | 1 |
| 13 | Characteristics of α-dendritic and eutectic structures in Sr-treated Al-Si casting alloys 显示文摘 | Liu L Samuel A M Samuel F H | 2004 | Journal of Materials Science2004，39，1： | 1 |
| 14 | Influences of alloying elements, solution treatment time and quenching media on quality indices of 413-type AI-Si casting alloys 显示文摘 | AMMAR H R MOREAU C SAMUEL A M SAMUEL F H DOTY H W | 2008 | Materials Science and Engineering A2008，489，1： | 1 |
| 15 | Room-temperature Ultraviolet Nanowire Nanolasers 显示文摘 | Michael H H Samuel M Henning F | 2001 | Science2001，292，5523： | 1 |
| 16 | Effects of Smodification, iron based intermetallics and aging treatment on the impact toughness of 356 A1-Si-Mg alloy显示文摘 | ELSEBAIE O SAMUEL A M SAMUEL F H | 2011 | Journal of Materials Science2011，46，9： | 1 |
| 17 | Influence of tin addition on the microstructure and mechanical properties of AI-Si-Cu-Mg and AI-Si-Mg casting alloys显示文摘 | MOHAMED A M A SAMUEL F H SAMUEL A M DOTY H W VALTIERRA S | 2008 | Metallurgical and Materials Transactions A2008，39，： | 1 |
| 18 | Review Various Aspects involved in the Production ofLow-hydrogen Aluminum Castings显示文摘 | SAMUEL A M SAMUEL SAMUEL F H | 1992 | Journal of Materials Science1992，27，： | 1 |
| 19 | Quantitative analysis of multi-protein interactions using FRET:application to the SUMO pathway显示文摘 | Martin S F Tatham M H Hay R T Samuel I D | | 0，，04： | 1 |
| 20 | Porosity formation in A1-9wt pct Si-3 wt pct Cu alloy system:metallograpic observation显示文摘 | Roy N Samuel A M Samuel F H | 1996 | Metallurgical Transactions A1996，27，： | 1 |
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