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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Quantification of epicardial fat:Which method can predict significant coronary artery disease?显示文摘AIM:To compare the predictive value of three methods of epicardial fat(EF) assessment for presence of significant coronary artery disease(CAD) [i.e.,epicardial fat volume(EFV),EFV indexed with body surface area(EFV/BSA) and EFV indexed with body mass index(EFV/BMI)].METHODS:The study was performed on 170 patients(85 women and 85 men) with clinical suspicion of CAD.They aged 26-89 years with a median age of 54 years.The patients were classified into three groups:Group 1:58 patients with normal coronary arteries; group 2:48 patients with non-significant CAD and group 3:64 patients with significant CAD.The three methods for assessment of epicardial fat were retrospectively studied to determine the best method to predict the presence of significant CAD.RESULTS:The three methods for epicardial fat quantification and measurements,i.e.,EFV,EFV/BSA and EFV/BMI with post- hoc analysis showed a significant difference between patients with significant coronary artery disease compared to the normal group.Receiver operating characteristic curve analysis showed no significant difference between the three methods of epicardial fat measurements,the area under curve ranging between 0.6 and 0.62.The optimal cut-off was 80.3 cm3 for EFV,2.4 cm3/m2 for EFV indexed with BMI and 41.7 cm3/(kg/m2) for EFV indexed with BSA.For this cut-off the sensitivity ranged between 0.92 and 0.94,while specificity varied from 0.31 to 0.35.CONCLUSION:Any one of the three methods for assessment of epicardial fat can be used to predict significant CAD since all have the same equivalent predictive value. | Zizi Saad Mohamed El-Rawy Ragab H Donkol Sami Boghattas | 2015 | World Journal of Cardiology2015，7，5： | 2 |
| 3 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 4 | The effect of noncontact, low-intensity, low-frequency, therapeutic ultrasound on lower extremity chronic wound pain, A retrospective chart review 显示文摘 | GEHLING M L SAMIES J H | 2007 | Ostomy Wound Management2007，53，3： | 1 |
| 5 | Stability of aflatoxins B1 and ochrotoxin A in brewing显示文摘 | CHU F S CHANG C C SAMY H | 1975 | Applied Microbiology1975，19，3： | 1 |
| 6 | Newer disease - modifying anfirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritis 显示文摘 | Samy S Pierre E Marie H | 2004 | The Amercann Journal of Medicine2004，117，： | 1 |
| 7 | A new and rapid method for determination of beer-spoilage ability of Lactobacilli显示文摘 | Sami M Yamashita H Kadokura | 1997 | J Am Sco Brew Chem1997，55，4： | 1 |
| 8 | Confinement model for axially loaded concrete confined by circular FRP tubes 显示文摘 | Amir Z F Sami H R | 2001 | Structure Journal2001，98，4： | 1 |
| 9 | Rectification of the background potassium current : a determinant of rotor dynamics in ventricular fibrillation 显示文摘 | SAMIE F H BERENFELD O ANUMONWO J | 2001 | Circ Res2001，89，12： | 1 |
| 10 | Multiple Shear Key Connections for Preeast Shear Wall Panels显示文摘 | RIZKALLA Sami H SERRETTE Reynaud L HEUVEL J Scott | 1989 | PCI Journal1989，34，2： | 1 |
| 11 | Transform-selective interference suppression algorithm for spread-spectrum communications 显示文摘 | Sami A Pertti H | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 12 | Brain-derived neurotrophic factor(BDNF)polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder显示文摘 | Kaija H Sami A Martti H | | 0，，01： | 1 |
| 13 | Foreign ownership and information asymmetry显示文摘 | Choi J 1 Lam K K Sami H | 2013 | Asia-Pacific Journal of Financial Studies2013，42，2： | 1 |
| 14 | Confinement model for axially loaded concrete confined by circular FRP tubes 显示文摘 | Amir Z Fam Sami H Rizkalla | 2001 | Structure Journal2001，98，4： | 1 |
| 15 | Anaerobic membrane reactor with phase separation for the treatment of cheese whey 显示文摘 | AHLEM S ILEM H SAMI S | 2006 | Bioresource Technology2006，，10： | 1 |
| 16 | Structural and Magnetic Studies of Ga-doped Yttrium Iron Garnet显示文摘Ga-doped Yttrium Iron Garnet (Y_(3)Ga_(x)Fe_(5-x)O_(12),Ga:YIG) was prepared by solid state reaction method and sintering at 1 300 ℃.Rietveld analysis of X-ray diffraction patterns indicated that all samples crystallized in a single cubic structure (space group Ia-3d) with decreasing lattice constant as Ga concentration increased.SEM surface micrograph images of YIG samples showed highly compacted grains with small reduction in the grain size with increasing Ga concentration.Raman spectroscopy measurements confirmed the replacement of Fe^(3+) ions by Ga^(3+) ions in the garnet structure was revealed by the observed blue shifts in Raman spectra.The saturation magnetization decreased from 28.2 to 4.98 emu g^(-1) with increasing x from 0.0 to 1.0 due to the preferential substitution of Ga^(3+) ions for Fe^(3+) ions at tetrahedral sites.Room temperature Mössbauer spectra for the samples revealed a reduction of the hyperfine field values for octahedral and tetrahedral sites,and the development of additional components with increasing Ga concentration.Analysis of the magnetic data and Mössbauer spectra confirmed that spin canting in the substituted garnets plays an important role in explaining the observed reduction of the saturation magnetization as x increased. | Khozima Hamasha Qassem I Mohaidat Mahdi Lataifeh Ibrahim Bsoul Sami H Mahmood | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，1： | 1 |
| 17 | A novel animal-component-free medium for rabies virus production in Vero cells grown on Cytodex 1 microcarriers in a stirred bioreactor显示文摘 | Samia Rourou Arno Ark Samy Majoul Khaled Trabelsi Tiny Velden Héla Kallel | | 0，，： | 1 |
| 18 | Contribution of the antioxi- dative property of a staxanthin to its protective effect on the promo- tion of cancer metastasis in mice treated with restraint stress 显示文摘 | Kurihara H Koda H A sami S | 2002 | Life Sci2002，70，21： | 1 |
| 19 | The prognostic significance of serial exercise testing after myocardial infarction显示文摘 | Sami M Kraemer H DeBusk RF | 1979 | Circulation1979，60，6： | 1 |
| 20 | Anaerobic membrane reactor with phase separation for the treatment of cheese whey显示文摘 | Ahlem S Ilem H Sami S | 2006 | Bioresource Technology2006，，10： | 1 |
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