|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 3 | Prevalence of microscopic colitis in patients with diarrhea of unknown etiology in Turkey显示文摘AIM: To investigate the prevalence and demography of microscopic colitis in patients with diarrhea of unknown etiology and normal colonoscopy in Turkey. METHODS: Between March, 1998 to July, 2005, 129 patients with chronic non-bloody diarrhea of unexplained etiology who had undergone full colonoscopy with no obvious abnormalities were included in the study. Two biopsies were obtained from all colonic segments and terminal ileum for diagnosis of microscopic colitis. On histopathologic examination, criteria for lymphocytic colitis (intraepithelial lymphocyte ≥ 20 per 100 intercryptal epithelial cells, change in surface epithelium, mononuclear infiltration of the lamina propria) and collagenous colitis (subepithelial collagen band thickness ≥ 10 μm) were explored. RESULTS: Lymphocytic colitis was diagnosed in 12 (9%) patients (Female/Male: 7/5, mean age: 45 year, range: 27-63) and collagenous colitis was diagnosed in only 3 (2.5%) patients (all female, mean age: 60 years, range: 54-65).CONCLUSION: Biopsy of Turkish patients with the diagnosis of chronic non-bloody diarrhea of unexplained etiology and normal colonoscopic findings will reveal microscopic colitis in approximately 10% of the patients. Lymphocytic colitis is 4 times more frequent than collagenous colitis in these patients. | Levent Erdem Sadιk Yιldιrιm Nihat Akbayιr Banu Yιlmaz Necati Yenice Orhan Sami Gültekin nder Peker | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 4 | What is needed of a taehyon if it is to be the dark energy? 显示文摘 | Copeland E J Garousi M R Sami M | 2005 | Phys Rev D2005，71，04： | 1 |
| 5 | A multi -criteria approach to contractor selection 显示文摘 | IBRAHIM M M MIKE J R SAMI M F | 2002 | Engi- neering Construction and Architectural Management2002，9，1： | 1 |
| 6 | Twenty years of inten- sive fertilization and competing vegetation suppression in loblolly pine plantations: Impacts on soil C,N, and microbial biomass显示文摘 | Sami W R Daniel M Bruce B | 2010 | Soil Biology & Biochemistry2010，42，5： | 1 |
| 7 | Functionalization at C-3a of tryptophan derived hexahydropyrrolo in- doles显示文摘 | BRUNCKO M CRICH D SAMY R | 1993 | Heterocycles1993，36，8： | 1 |
| 8 | Confinement model for axially loaded concrete confined by circular FRP tubes 显示文摘 | Amir Z F Sami H R | 2001 | Structure Journal2001，98，4： | 1 |
| 9 | Experimental and Analytical Modeling of Concrete-Filled Fiber-Reinforced Polymer Tubes Subjected to Combined Bending and Axial Loads 显示文摘 | Amir F Bart F Sami R | 2003 | Structural Journal2003，100，4： | 1 |
| 10 | Laparoseopie management of eryptorehidism in adults 显示文摘 | Kucheria R Sabai A Sami TA | 2005 | Eur Urol2005，48，3： | 1 |
| 11 | Laparoscopic pyeloplasty : comparison between retroperitoneoscopic and transperitoneal approach显示文摘 | Sami A Xavier G Jean-Baptiste R | 2010 | Urology2010，76，4： | 1 |
| 12 | Effectiveness of welded wire fabric as shear reinforcement in pretensioned prestressed concrete T-Beams显示文摘 | Xiaoyi X Sami R Kyuichi M | 1988 | ACI Structural Journal1988，85，4： | 1 |
| 13 | Cerebellopontine angle tumor composed of schwann and meningeal proliferations显示文摘 | Chen A F Samy R N Gantz B J | 2001 | Arch Otolaryngol Head Neck Surg2001，127，11： | 1 |
| 14 | Arterial embolectomy:a retrospective evaluation of 730 cases over 20 years显示文摘 | Sami Karapolat zgür Dag Mustafa Abanoz | 2006 | Surg Today2006，36，5： | 1 |
| 15 | Use of a novel ultrasonic surgical system for decompression of the facial nerve显示文摘 | SAMY R N KRISHNAMOORTHY K PENSAK M L | 2007 | Laryngoscope2007，117，5： | 1 |
| 16 | HPLC analysis of water-soluble vitamins(B2,B3,B6,B12and C)and fat-soluble vitamins(E,K,D,A andβ-carotene)of Okra(Abelmoschus esculentus)显示文摘 | SAMI R LI Y QI B | 2014 | J Chem2014，5，8： | 1 |
| 17 | Infectious diarrhea:newpathogens and new challenges in developed and developing areas显示文摘 | STEINER T S SAMIE A GUERRANT R L | 2006 | Clin Infec Dis2006，43，： | 1 |
| 18 | Identification of a novel calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-KB pathway显示文摘 | Samy R P Rajendran P Li F | 2012 | PLoS One2012，7，48： | 1 |
| 19 | Development and validation of an ion chromatography method for the determination of phosphate- binding of lanthanum carbonate显示文摘 | SAMY R FAUSTINO P J ADAMS W | 2010 | J Pharm Biomed Anal2010，51，5： | 1 |
| 20 | Concrete-filled steel tubes subjected to axial compression and lateral cyclic loads显示文摘 | Amir F Fran K S Q Sami R | 2004 | Journal of Structural Engineering2004，130，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员