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| 1 | 女性使用生物燃料相关的慢性阻塞性肺疾病:一项系统性回顾和meta分析显示文摘目的慢性阻塞性肺疾病(COPD)是世界范围内患病率和死亡率不断增长的主要疾病。女性的COPD患病率较男性增长更快,因为女性更常暴露在生物燃料燃烧产生的室内污染物中。 | 王臻(译) 施焕中(校) Adama Sana Serge M A Somda Nicolas Meda Catherine Bouland | 2018 | 英国医学杂志中文版2018，21，6： | 5 |
| 2 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Expression of the P2X_2 receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse显示文摘AIM:To examine whether the ob/ob mouse model of obesity is accompanied by enteric nervous system ab-normalities such as altered motility METHODS:The study examined the distribution of the P2X 2 receptor (P2X 2 R) in myenteric neurons of female ob/ob mice. Specifically, we used immunohistochemistry to analyze the co-expression of the P2X 2 R with neuronal nitric oxide synthase (nNOS), choline acetyltrans-ferase (ChAT), and calretinin (CalR) in neurons of the small intestine myenteric plexus in ob/ob and control female mice In these sections, we used scanning confocal microscopy to analyze the co-localization of these markers as well as the neuronal density (cm 2 ) and area profile (μm2) of P2X 2 R-positive neurons In addition, enteric neurons were labeled using the nicotinamide adenine dinucleotide (NA H) diaphorase method and analyzed with light microscopy as an alternate means by which to analyze neuronal density and areaRESULTS:In the present study, we observed a 29 6% increase in the body weight of the ob/ob animals (OG) compared to the control group (CG) In addition, the average small intestine area was increased by approxi-mately 29 6% in the OG compared to the CG Immu-noreactivity (IR) for the P2X 2 R, nNOS, ChAT and CalR was detectable in the myenteric plexus, as well as in the smooth muscle, in both groups This IR appeared to be mainly cytoplasmic and was also associated with the cell membrane of the myenteric plexus neurons, where it outlined the neuronal cell bodies and their processes P2X 2 R-IR was observed to co-localize 100% with that for nNOS, ChAT and CalR in neurons of both groups In the ob/ob group, however, we observed that the neuronal density (neuron/cm 2 ) of P2X 2 R-IR cells was in-creased by 62% compared to CG, while that of NOS-IR and ChAT-IR neurons was reduced by 49% and 57%, respectively, compared to control mice The neuronal density of CalR-IR neurons was not different between the groups Morphometric studies further demonstrated that the cell body profile area (μm2) of nNOS-IR, ChAT-IR and CalR-IR neurons was increased by 34%, 20% and 55%, respectively, in the OG compared to controls Staining for NA H diaphorase activity is widely used to detect alterations in the enteric nervous system; however, our qualitative examination of NA H-diaphorase positive neurons in the myenteric ganglia revealed an overall similarity between the two groups CONCLUSION:We demonstrate increases in P2X2R expression and alterations in nNOS, ChAT and CalR IR in ileal myenteric neurons of female ob/ob mice compared to wild-type controls. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Patricia Castelucci | 2012 | World Journal of Gastroenterology2012，18，34： | 2 |
| 4 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 5 | Inhibition of xanthine oxidase by phytic acid and its antioxidative action显示文摘 | SANAE M TOSHIAKI M | 2004 | Life Sci2004，74，： | 1 |
| 6 | Electrore- ductive block copolymerization of dichlorosilanes in the presence of disilane additives 显示文摘 | ISHIFUNE M SANA C ANDO M | 2011 | Polym Int2011，60，： | 1 |
| 7 | MiR-34b is associated with clinical outcome in triple-negative breast cancer patients 显示文摘 | Svoboda M Sana J Redova M | 2012 | Diagn Pathol2012，7，： | 1 |
| 8 | Gastric lymphography and detection of sentinel node显示文摘 | Sana T Katai H Sasako M | 2000 | Recent Results Cancer Res2000，157，2： | 1 |
| 9 | MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications 显示文摘 | Sana J Hajduch M Michalek J | 2011 | J Cell Mol Med2011，15，8： | 1 |
| 10 | Friction and wear of copper-graphite composites made with Cucoated and uncoated gra-phite powders 显示文摘 | Moustafa S F El-Badry S A Sana A M | 2002 | Wear2002，253，78： | 1 |
| 11 | An internal coordinate invariant reaction pathway显示文摘 | Sana M Reckinger G Leroy G | 1981 | Teoret Chim Acta1981，58，： | 1 |
| 12 | MiR-34b is associated with clinical outcome in triple-negative breast cancer patients显示文摘 | Svoboda M Sana J Redova M | | 0，，： | 1 |
| 13 | An estimation of craniofacial growth inthe untreated Class Ⅲ female with anterior crossbite显示文摘 | Miyajima K McNamara ames JA Sana M | 1997 | Am J Orthod Dentofacial Orthop1997，112，4： | 1 |
| 14 | MicroRNA expression profile associated with response to neoadjuvant ehemoradiotherapy in lo-cally advanced rectal cancer patients显示文摘 | Svoboda M Sana J Fabian P | 2012 | Radiation Oncol2012，7，2： | 1 |
| 15 | Endothelium-dependent contraction of rat thoracic aorta induced by gallic acid 显示文摘 | Sanae F M Iyaichi Y Hayashi H | 2003 | Phytother Res2003，17，2： | 1 |
| 16 | Dose-effect relationships between manganes exposure and neurological,neuropsychological and pulmonary function in confined space bridge welders显示文摘 | ROSEMARIE M B HARRY A R SANAE N | | 0，，03： | 1 |
| 17 | MiR-34b is associated withclinical outcome in triple - negative breast cancer patients显示文摘 | Svoboda M Sana J Redova M | 2012 | Di- agn Pathol2012，7，： | 1 |
| 18 | Suppression of PmRab7 by dsRNA inhibits WSSV or YHV infection in shrimp 显示文摘 | Ongvarrasopone C Chanasakulniyom M Sritunyaluck- sana K | 2008 | Marine Biotech- nology2008，10，37： | 1 |
| 19 | Moyamoya disease: A clinical spec- trum, literature review and ease series from a tertiary care hospital in Pakistan 显示文摘 | Sana S Ahmed I Ather M | 2009 | BMC Neurology2009，15，9： | 1 |
| 20 | Towards a smart project management infor-mation system显示文摘 | ALI J KIT SANA M | | 0，，04： | 1 |
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