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| 1 | IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C显示文摘AIM:To evaluate the effect of single nucleotide polymorphisms of interleukin(IL)-28B,rs12979860 on progression and treatment response in chronic hepatitis C.METHODS:Patients(n = 64;37 men,27 women;mean age,44 ± 12 years) with chronic hepatitis C,genotype 1,received treatment with peg-interferon plus ribavirin.Genotyping of rs12979860 was performed on peripheral blood DNA.Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment.Serum viral load,aminotransferase activity,and insulin level were measured.Insulin resistance index,body mass index,waist/hip ratio,percentage of body fat and fibrosis progression rate were calculated.Applied dose of interferon and ribavirin,platelet and neutrophil count and hemoglobin level were measured.RESULTS:A sustained virological response(SVR) was significantly associated with IL28B polymorphism(CC vs TT allele:odds ratio(OR),25;CC vs CT allele:OR,5.4),inflammation activity(G < 1 vs G > 1:OR,3.9),fibrosis(F < 1 vs F > 1:OR,5.9),platelet count(> 200 × 10 9 /L vs < 200 × 10 9 /L:OR,4.7;OR in patients with genotype CT:12.8),fatty liver(absence vs presence of steatosis:OR,4.8),insulin resistance index(< 2.5 vs > 2.5:OR,3.9),and baseline HCV viral load(< 10 6 IU/mL vs > 10 6 IU/mL:OR,3.0).There was no association with age,sex,aminotransferases activity,body mass index,waist/hip ratio,or percentage body fat.There was borderline significance(P = 0.064) of increased fibrosis in patients with the TT allele,and no differences in the insulin resistance index between groups of patients with CC,CT and TT alleles(P = 0.12).Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605,respectively(P < 0.001).Significant differences were found in the insulin resistance index(P = 0.01) between patients with and without steatosis.Patients with the CT allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon(P = 0.07).CONCLUSION:IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy.Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients. | Andrzej Ciela Monika Bociaga-Jasik Iwona Sobczyk-Krupiarz Mikolaj K Glowacki Danuta Owczarek Dorota Cibor Marek Sanak Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 2 | 阿司匹林诱发荨麻疹和白三烯C4合酶等位基因变异的家族性聚集显示文摘Background: We have reported that in patients with chronic idiopathic urticaria (CIU) who reacted adversely to aspirin, the frequency of the -444C allele of the leukotriene C4 synthase gene (LTC4S) was higher than in patients who tolerated aspirin well. Objectives: To study the pattern of aspirin-induced urticaria (AIU) in two families, with special interest on the polymorphisms of LTC4S (AA, AC, CC) and the glutathione Stransferase M1 and P1 genes (GSTM1 and GSTP1). Methods: Of 74 patients with CIU and a history of aspirin hypersensitivity studied by us, two patients (probands) gave a family history of aspirin intolerance. Oral challenge tests with aspirin were carried out in members of these families. Genomic DNA samples were obtained from peripheral blood to study the polymorphisms of LTC4S, GSTM1 and GSTP1. Results: In family 1 the aspirin challenge test confirmed AIU in three of five (60%) individuals, but in family 2 only in two of seven (29%). In both families, the variant genotypes of LTC4S (AC or CC) were present in the parents, but only one of them had CIU. In family 1, with both parents healthy, the three children had AIU; in two it was associated with variant LTC4S genotype. In family 2, urticaria following aspirin ingestion was present only with variant LTC4S genotype. In patients of both families with positive aspirin challenge test, deletion of the GSTM1 gene was present. Conclusions: AIU aggregates in families inheriting the LTC4S-444C allele. Segregation of aspirin sensitivity in these families does not follow a clear Mendelian pattern. A common deletion of GSTM1, one of several enzymes involved in conjugation of a wide range of electrophilic substances with glutathione, was present in all individuals ascertained to have AIU. | Mastalerz L. Setkowicz M. Sanak M. A. Szczeklik 王琼 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，6： | 3 |
| 3 | Platlet glycoprotein Ⅲa polymorphism, aspirin,and thrombin generation显示文摘 | Undas A Sanak M Musial J Szczeklik | 1999 | Lancet1999，353，： | 1 |
| 4 | Multiaxial lowcycle fatigue of 63Sn-37Pb solder显示文摘 | CHEN X JIN D SANAKE M | | 0，，01： | 1 |
| 5 | Pathogenesin and management of gestationl diabetesm-elitus显示文摘 | Sanake M | 1999 | Nippon Riusho1999，57，3： | 1 |
| 6 | Using reverse transcription and a competitive polymerase chain reaction for quantification of alpha1B-adrenoceptor mRNA 显示文摘 | Kreiner G Sanak M Zelek-Molik A | 2002 | Polish Journal of Pharmacology2002，54，4： | 1 |
| 7 | Pathogenesin and management of gestational diabetes mellitus显示文摘 | Sanake M | 1999 | Nippon Riusho1999，57，3： | 1 |
| 8 | Is atrial fibrillation associated with poor outcome after thrombolysis?显示文摘 | Sanak D Herzig R Kral M | 2010 | J Neurol2010，257，6： | 1 |
| 9 | Familialaggregation of aspirininduced urticaria and leukotriene Csynthase allelic variant 显示文摘 | Mastalerz L Setkowicz M Sanak M | | Br0，，： | 1 |
| 10 | Relationship between bleeding time,aspirin and the PLA1/A2 polymorphism of platelet glycoprotenin Ⅲa显示文摘 | Undas A Sanak M | 2000 | Br J Haematol2000，110，： | 1 |
| 11 | Relationship between bleeding time aspirin and the PIA1/A2 polymorphism of platelet glyeoprotein Ⅲa显示文摘 | Szczeklik A Undas A Sanak M | 2000 | Br J Haematol2000，110，4： | 1 |
| 12 | Role and control of texture in deep drawing steels 显示文摘 | SANAK M | 1982 | International Metals Reviews1982，27，6： | 1 |
| 13 | Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma显示文摘 | Szczeklik W Sanak M Szczeklik A | 2004 | J Allergy Clin Immunol2004，114，2： | 1 |
| 14 | Enhanced expression of the leukotriene C4 synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma显示文摘 | SANAK M PIERZCHALSKA M BAZANSOCHA S | 2000 | Am J Respir Cell Mol Biol2000，23，： | 1 |
| 15 | The presence of rhinovirus in lower airways of patients with bronchial asthma 显示文摘 | Wos M Sanak M Soja J | 2008 | Am J Respir Crit Care Med2008，177，10： | 1 |
| 16 | Polymorphisms of the 5, 10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida显示文摘 | Pietrzyk JJ Bik-Multanowski M Sanak M | 2003 | J Appl Genet2003，44，1： | 1 |
| 17 | Leukotriene C4 synthase (LTC4s) promoter polymorphism and risk of aspirin-induced asthma显示文摘 | Sanak M Simon HU Szczeklik A | | 0，，： | 1 |
| 18 | Enhanced ex- pression of the leukotriene C (4) synthase due to overactive tran- scription of an allelic variant associated with aspirin - intolerant asthma 显示文摘 | Sanak M Pierzchalska M Bazan - Socha S | 2000 | Am J Respir Cell Mol Biol2000，23，： | 1 |
| 19 | Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma 显示文摘 | Sanak M Simon H U Szczeklik A | 1997 | Lancet1997，350，9091： | 1 |
| 20 | Enhanced expression of the leukotriene C4 synthase due to overactive transcription of an allelic variant associated with aspirinintolerant asthma 显示文摘 | Sanak M Pierzchalska M Basan-Socha S | 2000 | Am J Respir Cell Mol Biol2000，23，3： | 1 |
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