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| 1 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments against Enterococcus faecalis in vitro显示文摘 | Basrani B Santos J M Pascon E | 2003 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2003，96，5： | 1 |
| 4 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 5 | Comparison of root-system efficiency and arsenic up- take of two fern Species 显示文摘 | SILVA GONZAGA M I SANTOS J A G COMERFORD N B | 2007 | Communications in Soil Science and Plant Analysis2007，38，： | 1 |
| 6 | Catechols from abietic acid-synthesis and evaluation as bioactive compounds显示文摘 | GIGANTE B SANTOS C SILVA A M | 2003 | Bioorganic and Medicinal Chemistry2003，11，8： | 1 |
| 7 | Influence of common lambsquarters (Chenopodium album) densities and phosphorus fertilization on lettuce显示文摘 | SANTOS B M DUSKY J A STALL W M | 2004 | Crop Protection2004，23，： | 1 |
| 8 | Influence of knee position on the postural stability index regis- tered by the Biodex Stability System 显示文摘 | PEREIRA H M DE CAMPOS T F SANTOS M B | 2008 | Gait Posture2008，28，4： | 1 |
| 9 | Sequential determination of fat- and water-soluble vitamins in green leafy vegetables during storage显示文摘 | Santos J Mendiola J A Oliveira M B P P | 2012 | Chromatogr A2012，1261，： | 1 |
| 10 | Formation of ultra- fine ferrite mierostructure in warm rolled and annealed C-Mn steel显示文摘 | Santos D B Bruzszek R K Rodrigues P C M | 2003 | Materials Science and Engineering: A2003，346，12： | 1 |
| 11 | Stability Studies of Carbonate Pesticides and Analysis by Gas Chroma- tography with Flame Ionization and Nitrogen - phosphorus Detection 显示文摘 | SANTOS M J D RUBIO B S FERNONDEZ -TOSTADO G T | 2001 | J Chromatography2001，921，： | 1 |
| 12 | Evidence for a positive regulatory role of strawberry (Fragaria x ananassa ) F WRKY1 and Arabidopsis AtWRKY75 proteins in resistance 显示文摘 | Vladimir-Shulaev S Maldonado A M Amil-Ruiz F Santos B Romero F Pliego-Alfaro F Munoz-Blanco J Caballero J L | 2009 | Journal of Experimental Botany2009，60，11： | 1 |
| 13 | The textual organization of research pa- per abstracts in applied linguistics显示文摘 | SANTOS M B D | 1996 | Text1996，，4： | 1 |
| 14 | On Digital Soil Mapping 显示文摘 | MCBRATNEY A B MENDONCA SANTOS M L MINASNY B | 2003 | Geoderma2003，117，12： | 1 |
| 15 | Retrogression and re-aging of 7075 aluminium alloy: Microstructural characterization显示文摘 | VIANA F PINTO A M P SANTO H M C LOPES A B | 1999 | Materials Processing Technology1999，9293，： | 1 |
| 16 | Ther- mal and mechanical profile of cast films from waterborne polyurethanes based on polyether block copolymers 显示文摘 | SANTOS C C DELPECH M C COUTINHO F M B | 2009 | Journal of Materials Science2009，44，5： | 1 |
| 17 | Catechols from abietic acid synthesis and evaluation as bioactive compounds 显示文摘 | Gigante B Santos C Silva A M | 2003 | Bioorg Med Chem2003，11，8： | 1 |
| 18 | Oxidation of CO,ethanol and toluene over TiO2 supported noble metal catalysts显示文摘 | SANTOS V P CARABINEIRO S A C TAVARES P B PEREIRA M F R ORFAO J J M FIGUEIREDO J L | | 0，，： | 1 |
| 19 | Use of RAPD to aid selection in common bean backcross breeding programs显示文摘 | Hagiwara W E Santos J B Carmo S L M | 2001 | Crop Breeding and Applied Biotechnology2001，1，4： | 1 |
| 20 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
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