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	题名	作者	年代	出处	被引量
1	Novel targeting approaches and signaling pathways of colorectal cancer: An insight显示文摘Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.	Ankita Tiwari Shivani Saraf Amit Verma Pritish Kumar Panda Sanjay K Jain	2018	World Journal of Gastroenterology2018，24，39：	6
2	Effect of simvastatin on fracture healing an experimental study 显示文摘	Saraf S K Singh A Garbyal R S	2007	Indian J Exp Bio12007，45，5：	1
3	Morphology of PbI2crystals grown by gel method显示文摘	BHAVSAR D S SARAF K B	2002	Cryst Res Technol2002，37，1：	1
4	Satellite Detection of Earthquake Thermal Infrared Precursors in Iran显示文摘	Saraf A k Rawat P	2008	Nature Hazard2008，47，：	1
5	4-Thiazolidinone:a biologically active scaffold显示文摘	Verma A Saraf K S	2008	European Journal of Medicinal Chemistry2008，43，5：	1
6	False topography perception phenomena and its correction 显示文摘	Saraf A K Das J D Agarwal B	1996	International Journal of Remote Sensing1996，17，18：	1
7	Bacopa monniera alleviates N (omega)-nitro-L-arginine arginine-induced but not MK-801-induced amnesia:a mouse Morris watermaze study显示文摘	Saraf M K Prabhakar S Anand A	2009	Neuroscience2009，160，1：	1
8	A new technique to remove false topographic perception phenomenon and its impacts in image interpretation显示文摘	Saraf A K Sinha S T Ghosh P	2007	International journal of Remote Sensing2007，28，5：	1
9	Performance estimation vis -f -vis design of mixed -feed lime shaft kiln 显示文摘	Vera C L Dave N G Saraf S K	1988	Zement - Kalk -Gips1988，9，：	1
10	OPAC usability: assessment through verbal protocol显示文摘	Guha T K Saraf V	2005	The Electronic Library2005，23，4：	1
11	Late presentation of fractures of the lateral condyle of the humerus in children 显示文摘	Saraf S K Khare G N	2011	Indian J Orthop2011，，：	1
12	Optimum step length selection rule in modified HL-RF method for structurai reliability 显示文摘	SANTOSH T V SARAF R K GHOSH A K	2006	International Journal of Pressure Vessels and Piping2006，83，10：	1
13	Integrated remote sensing and GIS for groundwater exploration and identification of artificial recharge sites显示文摘	Saraf A K Choudhury P R	1998	International Journal of Remote Sensing1998，19，10：	1
14	Multi-objective optimization of an industrial crude distillation unit using the elitist non-dominated sorting genetic algorithm 显示文摘	Inamdar S V Gupta S K Saraf D N	2004	Chemical Engineering Research and Design2004，82，5：	1
15	Multi-ob-jective optimization of an industrial crude distillation unitusing elitist non-dominated sorting genetic algorithm显示文摘	INAMDAR S V GUPTA S K SARAF D N	2004	Chemical Engineering Research and Design2004，82，5：	1
16	Zigzag slabs for sol-id-state laser amplifiers:batch fabrication and parasitic oscillation suppression显示文摘	SRIDHARAN A K SARAF S SINHA S	2006	Applied Optics2006，45，14：	1
17	Use of genetic algorithms in the optimization of free radical polymerizations exhibiting the Trommsdorff effect显示文摘	Chakravarthy S S S Saraf D N Gupta S K	1997	J Appl Polym Sci1997，63，4：	1
18	An aromatic amine as a co-curing agent in epoxy-bisimide blends显示文摘	Saraf M N Gupta R K Raman S V	1993	Journal of Applied Polymer Science1993，49，：	1
19	Viscosity of bulk free radical polymerizing systems under near-isothermal and non?isothermal conditions显示文摘	SangwaiJ S Saraf D N Gupta S K	2006	Polymer2006，47，30：	1
20	Flood inundation mapping using NOAA AVHRR data显示文摘	Sanjay K Jain Amn K Saraf Ajanta Goswami Tanvear Ahmad	2006	Water Resour Manage2006，20，：	1

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