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| 1 | Primary squamous cell carcinoma of the rectum: An update and implications for treatment显示文摘AIM: To provide an update on the aetiology, pathogenesis, diagnosis, staging and management of rectal squamous cell carcinoma(SCC).METHODS: A systematic review was conducted according to the preferred reporting items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE was performed with the reference list of selected articles reviewed to ensure all relevant publications were captured. The search strategy was limited to the English language, spanning from 1946 to 2015. A qualitative analysis was undertaken examining patient demographics, clinical presentation, diagnosis, staging, treatment and outcome. The quantitaive analysis was limited to data extracted on treatment and outcomes including radiological, clinical and pathological complete response where available. The narrative and quantitative review were synthesised in concert.RESULTS: The search identified 487 articles in total with 79 included in the qualitative review. The quantitative analysis involved 63 articles, consisting of 43 case reports and 20 case series with a total of 142 individual cases. The underlying pathogenesis of rectal SCC while unclear, continues to be defined, with increasing evidence of a metaplasia-dysplasia-carcinoma sequence and a possible role for human papilloma virus in this progression. The presentation is similar to rectal adenocarcinoma, with a diagnosis confirmed by endoscopic biopsy. Many presumed rectal SCC's are in fact an extension of an anal SCC, and cytokeratin markers are a useful adjunct in this distinction. Staging is most accurately reflected by the tumour-nodemetastasis classification for rectal adenocarcinoma. It involves examining locoregional disease by way of magnetic resonance imaging and/or endorectal ultrasound, with systemic spread excluded by way of computed tomography. Positron emission tomography is integral in the workup to exclude an external siteof primary SCC with metastasis to the rectum. While the optimal treatment remains as yet undefined, recent studies have demonstrated a global shift away from surgery towards definitive chemoradiotherapy as primary treatment. Pooled overall survival was calculated to be 86% in patients managed with chemoradiation compared with 48% for those treated traditionally with surgery. Furthermore, local recurrence and metastatic rates were 25% vs 10% and 30% vs 13% for the chemoradiation vs conventional treatment cohorts.CONCLUSION: The changing paradigm in the treatment of rectal SCC holds great promise for improved outcomes in this rare disease. | Glen R Guerra Cherng H Kong Satish K Warrier Andrew C Lynch Alexander G Heriot Samuel Y Ngan | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 5 |
| 2 | Power loss minimization in distribution system using network reconfiguration in the presence of distributed generation 显示文摘 | RAO R S RAVINDRA K SATISH K | 2013 | IEEE Trans on Evolutionary Computation2013，28，1： | 1 |
| 3 | Electrohydrodynamics deformation of thin liquid films near surfaces with topography 显示文摘 | ARUNA R SATISH K | 2014 | Physics of Fluids2014，26，12： | 1 |
| 4 | An investigation into the effects of graphite particles on the damping behavior of ZA-27 alloy composite material 显示文摘 | Girish B M Prakash K R Satish B M | 2011 | Materials and Design2011，32，： | 1 |
| 5 | Mechanical properties and fractography of zircon-particle-reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R KAMATH R SATISH B M | 1999 | Composite Science and Technology1999，59，： | 1 |
| 6 | Production and purification of a novel exoploysaccharide from lactic acid bacterium Streptococcus phocae PI80 and its functional characteristics activity in vitro显示文摘 | KANMANI P SATISH KUMAR R YUVARAJ N | 2011 | Bioresource Technology2011，102，： | 1 |
| 7 | Sliding wear behavior of zircon particles reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R SATISH B M KAMATH R | 1999 | Wear1999，224，： | 1 |
| 8 | How Do Surfactants and DTT Affect the Size Dynamics Activity and Growth of Soluble Lysozyme Aggregates显示文摘 | Satish K Vijay K R Rajaram S | | 0，，： | 1 |
| 9 | Effect of SiC particle reinforcement on the unlubricated sliding wear behavior of ZA-27 alloy composites 显示文摘 | SHARMA S C GIRISH B M KAMATH R SATISH B M | 1997 | Wear1997，213，： | 1 |
| 10 | A simulation-based comparison of TOC and traditional accounting performance measures in a process industry 显示文摘 | SATISH MEHRA R ANTHONY INMAN GREGORY TUITE | 2005 | Journal of Manufacturing Technology Management2005，16，3： | 1 |
| 11 | Multiple target tracking using maximum likelihood principle 显示文摘 | Satish A Kashyap R L | 1995 | IEEE Transactions on Signal Processing1995，43，7： | 1 |
| 12 | Y-junction carbon nanotubes显示文摘 | SATISH KUMAR B C THOMAS P J GOVINDARAJ A RAO C N R | 2000 | Appl Phys Lett2000，77，： | 1 |
| 13 | Probiotics and its functionally valuable products-A review显示文摘 | KANMANI P SATISH KUMAR R YUVARAJ N | 2013 | Critical Reviews in Food Science and Nutrition2013，53，6： | 1 |
| 14 | A Test System for Teaching Overall Power System Reliability As- sessment显示文摘 | Billimon R R Satish Jormavithula | 1996 | IEEE Transactions on Power systems1996，11，4： | 1 |
| 15 | Macroporous carbon from human hair:A journey towards the fabrication of high energy Li-ion capacitors显示文摘 | SATISH R ARAVINDAN V LING W C | 2015 | Electrochimica Acta2015，182，： | 1 |
| 16 | Stability of multilobe hybrid bearing with short sills-part II显示文摘 | GHOSH M K SATISH M R | 2003 | Tribology International2003，36，： | 1 |
| 17 | A test system for teaching overall power system reliability assessment显示文摘 | Billinton R Satish Jonnavithula | 1996 | IEEE Transactions on Power System1996，11，4： | 1 |
| 18 | A note on the corrosion characteristic of ZA-27/zircon particulate composites in acidic medium 显示文摘 | SHARMA S C SOMASHEKAR D R SATISH B M | 2001 | Journal of Materials Processing Technology2001，118，： | 1 |
| 19 | Stability of multilobe hybrid bearing with short sills-part II显示文摘 | GHOSH M K SATISH M R | 2003 | Tribology International2003，36，： | 1 |
| 20 | A Survey:Methods of Feature Based Image Registration显示文摘 | Sandip R Satish K | 2012 | International Journal of Electronics Communication and Computer Engineering2012，3，4： | 1 |
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