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1脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patientsOddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD 2011中华神经外科疾病研究杂志2011,10,5:21
2Accuracy of clinical diagnosis of idiopathic Parkinson's disease:a clinicopathologic study of 100 cases显示文摘Hughes A J Daniel SE Kilford L 1992J Neurol Neurosurg Psychiatry1992,55,3:10
3Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test?显示文摘AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after surgery.RESULTS: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease.Gregory L Falk John Beattie Alvin Ing SE Falk Michael Magee Leticia Burton Hans Van der Wall 2015World Journal of Gastroenterology2015,21,12:2
4Vasostatin,a calreticulin fragment,inhibits angiogenesis and suppresses tumor growth显示文摘Pike SE Yao L Jones KD 1998J Exp Med1998,188,12:2
5Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth显示文摘Pike SE Yao L Setsuda J 1999Blood1999,94,7:2
6The value of the site and extent of Y chromosome microdeletions on spermatogenesis 显示文摘Kleiman SE Yogev L Paz G 2002Harefuah2002,141,:1
7Sleep apnea in patientsreceiving growth hormone显示文摘Gerard JM Garibaldi L Myers SE 1997Clin Pediatr Phila1997,36,6:1
8Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth显示文摘Pike SE Yao L Jones KD 1998J Exp Med1998,188,:1
9Efficacy and tolerability of losartan potassium and antenolol in patient with mild to moderate essential hypertension显示文摘Dahlof B Keller SE Makrisl L 1995Am J Hypertens1995,8,:1
10Combined aerobic heterotrophic oxidation nitrification and denitrification in a permeable-support biofilm显示文摘Timberlake D L Strand SE Williamson KJ 1988Water Research1988,22,12:1
11Botanical and dietary sup-plements for menopausal symptoms: what works, what does not显示文摘Geller SE Studee L 2005J Womens Health (Larchmt)2005,14,7:1
12Characterization of MtnE,the fifth metallothionein member in Drosophila显示文摘Atanesyan L Günther V Celniker SE 2011J Biol Inorg Chem2011,16,7:1
13Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases显示文摘Hughes AJ Daniel SE Kilford L 1992J Neurol Neurosurg Psychiatry1992,55,3:1
14Fbxw7o~- and GSK3- mediated degradation of pl00 is a pro-survival mecha- nism in multiple myeloma 显示文摘Busino L Millman SE Scotto L 2012Nat Cell Biol2012,14,4:1
15Accuracy of clinical diagnosis of idiopathic ParkinsonJs disease:a clinico-pathological study of 100 cases 显示文摘Hughes A J Daniel SE Kilford L 1992Neurol Neurosurg Psychiatry1992,55,3:1
16Molecular characterization of mild-to-moderate hemophilia A : detection of the mutation in 25 of 29 patients by denaturing gradient gel electrophoresis显示文摘Higuchi M Antonarakis SE Kasch L 1991Proc Natl Acad Sci USA1991,88,19:1
17Ebstein's anomaly:factors associ- ated with death in childhood and adolescence:a multi-centre, long-term study 显示文摘Kapusta L Eveleigh RM Poulino SE 2007Eur Heart J2007,28,:1
18Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans 显示文摘IZHU L KRETH J CROSS SE 2006Microbiology2006,152,8:1
19Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS) 显示文摘Humphries SE Nicaud V Margalef J Tiret L Talmud PJ 1998Arterioscler Thromb Vasc Biol1998,18,4:1
20The development of the self in the era of the internet and role-playing fantasy games显示文摘Allison SE von Wahlde L Shockley T 2006Am J Psychiatry2006,163,3:1
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