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| 1 | The bounds and realization of spatial stiffnesses achieved with simple springs connected in parallel显示文摘 | Huang S Schimmels J M | 1998 | IEEE Transactions on Robotics and Automation1998，14，3： | 2 |
| 2 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 3 | Very low-birthweight-infants conceived by in vitro fertilization are not at higher risk for mortality and morbidity: a population-based study显示文摘 | Schimmel MS Hammerman C Lusky A | 2006 | Fertil Steril2006，85，4： | 1 |
| 4 | Impact of vocal effort variability on automatic speech recognition 显示文摘 | ZELINKA P SIGMUND M SCHIMMEL J | 2012 | Speech Communica- tion2012，54，6： | 1 |
| 5 | Platelet-rich plasma:Growh factor enhancement for bone grafts 显示文摘 | Marx RE Carlson ER Eichstaedt RM Schimmele SR Strauss JE Georgeff KR | 1998 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod1998，85，6： | 1 |
| 6 | White matter medullary infarcts:acute subcortical infarction in the centrum ovale显示文摘 | Read SJ Pettigrew L Schimmel L | 1998 | Cerebrovasc Dis1998，8，： | 1 |
| 7 | A Celebration in Honor of Issac Newton显示文摘 | Schimmel J | 1991 | Mathematics Teacher1991，84，9： | 1 |
| 8 | Acetabular reconstruction with impacted morselized cancellous allografts in cemented hip arthroplasty显示文摘 | Schimmel JW Buma P Versleyen D | 1998 | J Arthroplasty1998，13，： | 1 |
| 9 | The influence of the molecular weight distribution of network chains on the mechanical properties of polymer networks显示文摘 | Schimmel K Heinrich G | 1991 | Colloid and Polymer Science1991，269，9： | 1 |
| 10 | The inverse S - transform in filters with time-frequency localization显示文摘 | Schimmel M Gallart J | 2005 | IEEE Transactions on Signal Processing2005，53，11： | 1 |
| 11 | Characterization of pepsinogen C as a potential biomarker for gastric cancer using a histopreteomic approach 显示文摘 | Melle C Ernst G Schimmel B | 2005 | J Proteome Res2005，4，5： | 1 |
| 12 | The study of the stability of reference materials by isochronous measurements显示文摘 | Lamberty A Schimmel H Pauwels J | 1998 | Fresenius J Anal Chem1998，360，3： | 1 |
| 13 | Performance criteria for reference measurement procedures and reference materials显示文摘 | SCHIMMEL H ZEGERS I | 2015 | Clin Chem Lab Med2015，53，6： | 1 |
| 14 | Purification and characterization of a lovastatin esterase from Clonostachys compactiuscula显示文摘 | SCHIMMEL T G BORNEMAN W S CONDERM J | 1997 | Applied and Environmental Microbiology1997，63，4： | 1 |
| 15 | Gastrointestinal tract bleeding of unknown origin显示文摘 | Spechler SJ Schimmel EM | 1982 | Ach Inter Med1982，142，： | 1 |
| 16 | Edentulism as part of the gen- eral health problems of elderly adults显示文摘 | Polzer I Schimmel M Mtier F | 2010 | Int Dent J2010，60，3： | 1 |
| 17 | Fast calculation method for optical diffraction on tilted planes by use of the angular sprctrum of plane waves显示文摘 | K Matsushima H Schimmel F Wyrowski | 2003 | J Opt Soc Am A2003，20，9： | 1 |
| 18 | The- transform from a wavelet point of view显示文摘 | VENTOSA S SIMON C SCHIMMEL M | 2008 | IEEE Trans- actions on Signal Processing2008，56，7： | 1 |
| 19 | Correlation power analysis in frequency domain显示文摘 | Schimmel O Duplys P Boehl E | 2010 | COSADE2010，，： | 1 |
| 20 | The incidence of congenital heart defects in very low birth weight and extremely low birth weight infants 显示文摘 | GODFREY M SCHIMMEL M S HAMMERMAN C | 2010 | Isr Med Assoc J2010，12，1： | 1 |
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