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| 1 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 4 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 5 | Cerebral gnathostomiasis as a cause of an extended intracranial bleeding显示文摘 | Germann R Sch chtele M Nessler G | 2003 | Kiln Padiatr2003，215，4： | 1 |
| 6 | Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors显示文摘 | Siegsmund M Brinkmann U Scháffeler E Weirich G Schwab M Eichelbaum M | 2002 | J Am Soc Nephrol2002，13，7： | 1 |
| 7 | Cloning,sequencing,and characterization of a heat-and alkali-stable type Ⅰ pullulanase from Anaerobranca gottschalkii显示文摘 | Bertoldo C Armbrecht M Becker F Sch(a)fer T Antranikian G Liebl W | | 0，，06： | 1 |
| 8 | The Netherlands:Health system review显示文摘 | Sch fer W Kroneman M Boerma W van den Berg M Westert G Devill é W and van Ginneken E | | 0，，01： | 1 |
| 9 | Isolated noncompaction of the myocardium in adults显示文摘 | Ritter M Oechslin E Sut sch G | 1997 | Mayo Clin Proc1997，72，1： | 1 |
| 10 | A Model for Exponential Decaying Inventory显示文摘 | Ghare P M Sch rader G F | 1963 | Journal of Engineering1963，14，： | 1 |
| 11 | Fertilizing commercial forest species in Southern Africa:research progress and problems(Part 1)显示文摘 | Herbert M A Schnau A P G | 1989 | South African Forestry Journal1989，151，： | 1 |
| 12 | Steroid hormone receptors:many actors in search of a plot显示文摘 | Beato M Herrlich P Schütz G | | 0，，06： | 1 |
| 13 | Photocatalytic oxidation of water to O2 on AgCl-coated electrodes显示文摘 | Lanz M Schürch D Calzaferri G | 1999 | Journal of Photochemistry and Photobiology A:Chemistry1999，120，2： | 1 |
| 14 | Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice显示文摘 | Usher Michael G Duan Sheng Zhong Ivaschenko Christine Y Frieler Ryan A Berger Stefan Schütz Günther Lumeng Carey N Mortensen Richard M | 2010 | Journal of Clinical Investigation2010，，9： | 1 |
| 15 | Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point显示文摘 | Ndrepepa G Berger P B Mehilli J Seyfarth M Neumann F J Sch?mig A | 2008 | J Am Coll Cardiol2008，51，： | 1 |
| 16 | FDG-PET/CT in re-staging of patients with lymphoma显示文摘 | L. S. Freudenberg G. Antoch P. Schütt T. Beyer W. Jentzen S. P. Müller R. G?rges M. R. Nowrousian A. Bockisch J. F. Debatin | 2004 | European Journal of Nuclear Medicine and Molecular Imaging2004，，3： | 1 |
| 17 | The nuclear receptor superfamily: the second decade显示文摘 | Mangelsdorf DJ Thummel C Beato M Herrlich P Schütz G Umesono K | 1995 | Cell1995，83，6： | 1 |
| 18 | Migraine,vascular risk,and cardiovascular events in women:prospective cohort study显示文摘 | Kurth T Schürks M Logroscino G | | 0，，： | 1 |
| 19 | A Model for Exponential Decaying Inventory显示文摘 | Ghare P M Sch rader G F | 1963 | Journal of Engineering1963，14，： | 1 |
| 20 | Status of and experience with NOx reduction in coal-fired power plants显示文摘 | St H M Sch T H Kr G H | 1997 | Proceedings of the Institution of Mechanical Engineers Part A: Journal of Power and Energy1997，211，01： | 1 |
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