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| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Müller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
| 5 | A Model for Exponential Decaying Inventory显示文摘 | Ghare P M Sch rader G F | 1963 | Journal of Engineering1963，14，： | 1 |
| 6 | Phase Ⅱ study of biweekly cetuximab in combination with irinotecan as second-line treatment in patients with platinum-resistant gastro-oesophageal cancer显示文摘 | Schnnemann K R Yilmaz M Bjerregaard J K Nielsen K M Pfeiffer P | 2012 | Eur J Cancer2012，48，： | 1 |
| 7 | Fertilizing commercial forest species in Southern Africa:research progress and problems(Part 1)显示文摘 | Herbert M A Schnau A P G | 1989 | South African Forestry Journal1989，151，： | 1 |
| 8 | Steroid hormone receptors:many actors in search of a plot显示文摘 | Beato M Herrlich P Schütz G | | 0，，06： | 1 |
| 9 | Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease显示文摘 | Hunt A Schnknecht P Henze M | 2007 | Psychiatry Res2007，155，2： | 1 |
| 10 | Definition of false-positive reactions in screening for hepatitis C virus antibodies 显示文摘 | Schrter M Feucht HH Schfer P | 1999 | J Clin Microbiol1999，37，1： | 1 |
| 11 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Müller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
| 12 | Imaging in early posttraumatic complex regional pain syndrome:a comparison of diagnostic methods显示文摘 | Schürmann M Zaspel J Lohr P | | 0，，05： | 1 |
| 13 | Use of the less invasive stabilization system (LISS) in patients with distal femoral (AO33) fractures:a prospectivemulticenter study显示文摘 | Schütz M Mül er M Regazzoni P | | 0，，02： | 1 |
| 14 | Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point显示文摘 | Ndrepepa G Berger P B Mehilli J Seyfarth M Neumann F J Sch?mig A | 2008 | J Am Coll Cardiol2008，51，： | 1 |
| 15 | Grassland responses to grazing: Effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | SCHNBACH P WAN H GIERUS M | 2011 | Plant and Soil2011，340，： | 1 |
| 16 | Control of an SCR catalytic converter system for a mobile heavy-duty application显示文摘 | Sch'ar C M Onder C H Geering H P | 2006 | IEEE Transactions on Control Systems Technology2006，14，4： | 1 |
| 17 | The nuclear receptor superfamily: the second decade显示文摘 | Mangelsdorf DJ Thummel C Beato M Herrlich P Schütz G Umesono K | 1995 | Cell1995，83，6： | 1 |
| 18 | Analysis of efficacy and failure in proximal humerus fractures treated with locking plates显示文摘 | Agudelo J Schürmann M Stahel P | 2007 | J Orthop Trauma2007，21，10： | 1 |
| 19 | study of antagonism against Listeria monocytogees in vacuum packaged salmon 显示文摘 | Sch(ibitz R P B6rquez P A Costa M E Ciampi L R Bactefiocin like substance production by Carnobacterium piscicola in a continuous system with three culture brooths | 2006 | Brazilian Journal of Microbiology2006，37，： | 1 |
| 20 | Does a continuous positive airway pressure by face mask improve patients with acute cardiogenic pulmonary edema due to left ventricular diastolic dysfunction?显示文摘 | BENDJELID K SCHTZ N SUTER P M | 2005 | Chest2005，127，3： | 1 |
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