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| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Improved performance of an electrically initiated HF laser显示文摘 | ARNOLD G P WENZEL R G | 1973 | IEEE J Quantum Electron1973，9，4： | 1 |
| 4 | Current understanding of sepsis显示文摘 | Wenzel R P Pinsky M R Ulevitch R J | 1996 | Clin Infect Dis1996，22，3： | 1 |
| 5 | Continuous production of ethylene-based diblock copolymers using coordinative chain transfer polymerization显示文摘 | Hustad P D Kuhlman R L Arriola D J Carnahan E M Wenzel T T | | 0，，： | 1 |
| 6 | Division and apoptosis of E2f-deficient retinal progenitors显示文摘 | CHEN D PACAL M WENZEL P | 2009 | Nature2009，462，7275： | 1 |
| 7 | Tigecycline显示文摘 | Wenzel R Bate G Kirkpatrick P | 2005 | Nat Rev Drug Discov2005，4，10： | 1 |
| 8 | Gramnegative bacilli as nontransient flora on the hands of hospital personnel显示文摘 | GUENTHNER S H HENDLEY J Q WENZEL R P | 1987 | J Clin Microb1987，25，3： | 1 |
| 9 | Nitrate tolerance as a model of vascular dysfunction:roles of mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress显示文摘 | Daiber A Oelzel M Wenzel P | 2009 | Pharmacol Rep2009，61，1： | 1 |
| 10 | The impact of hospital-acquired bloodstream infection 显示文摘 | Wenzel R P Edmond M B | 2001 | Emerg Infect Dis2001，7，： | 1 |
| 11 | Mechanisms underlying recoupling of Enos by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced dibetes mellitus显示文摘 | Wenzel P Daiber A Oelze M | 2008 | Atherosclerosis2008，198，1： | 1 |
| 12 | Nosocomial bloodstream infections显示文摘 | Pittet D Wenzel R P | 1995 | Arch Intern Med1995，155，7： | 1 |
| 13 | Severe asthma in adults:what are the important questions显示文摘 | Chanez P Wenzel SE Anderson GP | | 0，，： | 1 |
| 14 | Nitrate tolerance as a model of vascular dysfunction : roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress 显示文摘 | Daiber A Oelze M Wenzel P | 2009 | Pharmaeol Rep2009，61，1： | 1 |
| 15 | Mechanisms under lying recoupling of enos By HMG-CoA reductese inhibition in a rat model of streptozotocin-induced diabetes mellitus显示文摘 | Wenzel P Daiber A Oalze M | 2008 | Atherosclerosis2008，198，1： | 1 |
| 16 | Role of reduced lpoic acid in the redox regulation of mitochondrial alde- hyde dehydrogenase ( ALDH-2 ) activity : implications for mitochon-drial oxidative stress and nitrate tolerance显示文摘 | Wenzel P Hink U Oelze M | 2007 | Biol Chem2007，282，1： | 1 |
| 17 | Tigecycline显示文摘 | Wenzel R Bate G Kirkpatrick P | 2005 | Nat Rev Drug Discov2005，4，10： | 1 |
| 18 | Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment显示文摘 | Naveiras O Nardi V Wenzel P L | 2009 | Nature2009，460，7252： | 1 |
| 19 | Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension显示文摘 | Schulz E Jansen T Wenzel P | 2008 | Antloxid Redox Signal2008，10，6： | 1 |
| 20 | Tigecycline 显示文摘 | Wenzel R Bate G Kirkpatrick P | 2005 | Nat RevDrug Discov2005，4，10： | 1 |
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