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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Soybean trypsin inhibitors reduce absorption of exogenous and in- crease loss of endogenous protein in miniature pigs 显示文摘 | BARTH C A LUNDING B SCHMITZ M | 1993 | Nutrition1993，123，12： | 1 |
| 3 | Multivariate Logistic Analysis of Risk Factors for Stroke in Tilburg,the Netherlands显示文摘 | Herman B Schmitz P I Leyten A C | 1983 | Am J Epidemiol1983，118，4： | 1 |
| 4 | Expression pattern, genomic cloning and RFLP analyses of the swine PIT-1 gene 显示文摘 | Yu T P Schmitz C B Rothschild M F | 1994 | Animal Genetics1994，25，： | 1 |
| 5 | Expression pattern,genomic cloning and RFLP analyses of the swine POU1F1 gene显示文摘 | Yu T P Schmitz C B Rothschild M F | | 0，，： | 1 |
| 6 | Doppler-derived parameters of diastolic left ventricular function in preterm infants with a birth weight 《 1 500 g: reference values and differences to term infants 显示文摘 | Schmitz L Stiller B Pees C Koch H Xanthopoulos A Lange P | 2004 | Early Hum Der2004，76，2： | 1 |
| 7 | HinfI polymorphism at the bovine PIT1 locus 显示文摘 | WOOLLARD J SCHMITZ C B FREEMAN A E | 1994 | J Anim Sci1994，72，12： | 1 |
| 8 | NCAM expression induces neurogenesis in vivo显示文摘 | Boutin C Schmitz B Cremer H | 2009 | Eur J Neurosci2009，30，7： | 1 |
| 9 | A genome-wide survey of RAS transformation targets显示文摘 | Zuber J Tchernitsa O I Hinzmann B Schmitz A C Grips M Hellriegel M | 2000 | Nat Genet2000，24，： | 1 |
| 10 | Effect of global system for mobile communication (GSM) microwave exposure on blood-brain barrier permeability in rat显示文摘 | Fritze K Sommer C Schmitz B | 1997 | Acta Neuropathol1997，94，5： | 1 |
| 11 | Soybean trypsin inhibitors reduce absorption of exogenous and increase loss of endogenous protein in iniature pigs显示文摘 | Barth C A Lurnling B Schmitz M | 1993 | Nutrition1993，，123： | 1 |
| 12 | Association of PIT-1 polymorphism swith growth and carcass traits in pigs显示文摘 | Yu T P Tuggle C K Schmitz C B | 1995 | Journal of Animal Science1995，73，5： | 1 |
| 13 | Nueronal stress response and neuronal cell damage after cardiocirculatory arrest in rats 显示文摘 | Bottiger BW Schmitz B Wiessner C | 1998 | J Cereb Blood Flow Metab1998，18，10： | 1 |
| 14 | Epidemiology of urinary bladder cancer:from tumor development to patient~ death显示文摘 | Murta - Nascimento C Schmitz - Drager B J Zeegers MP | 2007 | World J Urol2007，25，3： | 1 |
| 15 | Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells 显示文摘 | RADTKE C SCHMITZ B SPIES M | 2009 | Int J Dev Neuros- ci2009，27，8： | 1 |
| 16 | Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance显示文摘 | Bonapace L Bornhauser B C Schmitz M | 2010 | J Clin Invest2010，120，4： | 1 |
| 17 | Association of PIT-1 polymorphisms with growth and carcass traits in pigs 显示文摘 | Yu T P Tuggle C K Schmitz C B | 1995 | Journal of Animal Science1995，73，： | 1 |
| 18 | Anesthesia during high-field in-traoperative resonance imaging:experience with eighty consecutivecases显示文摘 | Schmitz B Nimsky C Wendel G | 2003 | J Neurosurg Anesth2003，15，3： | 1 |
| 19 | Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways 显示文摘 | Yasuda K Yu P Kirschning C J Schlatter B Schmitz F Heit A | 2005 | J Immunol2005，174，10： | 1 |
| 20 | EEG variables as measures of arousal during propofol anaesthesia for general surgery in children:rational selection and age dependence显示文摘 | C Jeleazcov J Schmidt B Schmitz | 2007 | British Journal of Anaesthesia2007，99，： | 1 |
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