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| 1 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 2 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 3 | Localization of eosinophils to airway nerves and effect on neuronal Mmuscarinic receptor function显示文摘 | Costello R W Schofield B H Kephart G M | 1997 | Am J Physiol1997，273，11： | 1 |
| 4 | Checklist of the mosses of Canada Ⅱ显示文摘 | IRELAND R R BRASSARD G R SCHOFIELD W B VITT D H | 1987 | Lindbergia1987，13，： | 1 |
| 5 | A murine model of IgE-mediated cow' s milk hypersensitivity 显示文摘 | LI X M SCHOFIELD B H HUANG C K | 1999 | J Allergy Clin Immunol1999，103，21： | 1 |
| 6 | Prepa ration of core-shell polymer colloid particles by encapsu lation显示文摘 | Ottewill R H Schofield A B Waters J A | 1997 | Colloids Polymer Science1997，275，3： | 1 |
| 7 | The use of olfactory and other cues for social recognition by juvenile pigs显示文摘 | Kristensen H H Jones R B Schofield C P | 2001 | Apply Animal Behavior Science2001，72，4： | 1 |
| 8 | Preparation of core-shell polymer colloid particles by encapsulation显示文摘 | Ottewill R H Schofield A B Waters J A | 1997 | Colloid Polym Sci1997，275，3： | 1 |
| 9 | Treatment of uveitis with pyrimethamine(daraprim)显示文摘 | PERKINS E S SCHOFIELD P B SMITH C H | 1956 | Br J Ophthalmol1956，40，10： | 1 |
| 10 | The genus Taxitheliumi'Bryopsida, Sematophyllaceae) in Australia 显示文摘 | RAMSAY H P SCHOFIELD W B TAN B C | 2002 | Australian Sys-tematic Botany2002，15，： | 1 |
| 11 | A murine model of IgE-mediated cow 's milk hypersensitivity 显示文摘 | LI X M SCHOFIELD B H HUANG C K | 1999 | J Allergy Clin Immunol1999，103，21： | 1 |
| 12 | Localization of eosinophils to arirway nerves and effect on neuronal M2 muscarinic receptor function显示文摘 | COSTELLO R W SCHOFIELD B H KEPHART G M | 1997 | Am J Physiol1997，273，17： | 1 |
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