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	题名	作者	年代	出处	被引量
1	Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients显示文摘Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation.	Mark Schrader Markus Müller Rüdiger Heicappell Bernd Straub Kurt Miller	2001	Asian Journal of Andrology2001，3，4：	3
2	Springer-verlag Berlin显示文摘	Korte B Lovasz L Schrader R Greedodis	1991	Heidelberg1991，，：	2
3	Nitric oxide induced contractile dysfunction is related to a reduction in myocardial energy generation 显示文摘	Kelm M Schafer S Dahmann R Dolu B Perings S Decking U K Schrader J Strauer B E	1997	Cardiovascular Research1997，36，2：	1
4	Better Bones Buddies:an osteoporosis prevention program 显示文摘	SCHRADER S L BLUE R HORNER A	2005	J Sch Nurs2005，21，2：	1
5	Transcatheter closure of secundum atrial septal defects in adults with the Amplatzer septal occluder: interme- diate and long-term results 显示文摘	Spies C Timmermanns I Schrader R	2007	Clin Res C ardiol2007，96，6：	1
6	Discrin inating small molecule DNA binding modes by single molecule force spectroscopy显示文摘	Krautbauer R Pope L H Schrader T E	2002	FEBS Lett2002，510，3：	1
7	Hemodynamic effects of a single intravenous infusion of prostaglandin E1 in patients with clinically moderate to severe chronic heart failure显示文摘	Schrader N Erbel R Wittlich N		0，，11：	1
8	Prevalence of low cortisol valuse in term and near-term infants with vasopressor-resistant hypotension 显示文摘	Fernandez EF Schrader R Watterberg KL	2005	J Perinatol2005，25，2：	1
9	The develop-mental potential of the human oocytes is related to the dissolved content of follicular fluid:association with vascular endothelial growth factor levels and perifollicu-lar blood flow charactcristics显示文摘	Antczak M Schrader R	1997	Hum Reprod1997，12，5：	1
10	Systematics of Alnus maritime (seaside alder)resolved by ISSR polymorphisms and mor- phological characters显示文摘	Schrader J A Graves W R	2004	J Am Soc Horic Sci2004，129，：	1
11	Systematics of Alnus maritime (seaside alder)resolved by ISSR polymorphisms and mor- phological characters 显示文摘	Schrader J A GravesW R	2004	J Am Soc Horic Sci2004，129，：	1
12	Expression of novel genes during somatic embryogenesis of suspension-cultured carrot ceils (Daucus carota)显示文摘	Schrader S Kaldenhoff R Richter G	1997	J Plant Physiol1997，150，：	1
13	Contrast material-induced renal failure: an overview 显示文摘	Schrader R	2005	Interv Cardial2005，18，22：	1
14	Component rotation andanterior knee pain after total knee arthroplasty显示文摘	Barrack R L Schrader T Bertot AJ	2001	Clin Orthop RelatRes2001，392，：	1
15	High-resolution tensor MRI elastography for breast tumour detection 显示文摘	Sinkus R Lorenzen J Schrader D	2000	Phys Med Biol2000，45，：	1
16	Opportunity recog- nition as a creative process显示文摘	HILLS G SCHRADER R LUMPKIN T	1999	Frontiers of Entrepreneurship Research1999，19，19：	1
17	Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsensemediated decay pathway显示文摘	Schrader R Young C Kozian D	2006	J Biol Chem2006，281，35：	1
18	Different frequencies of angiotensin -converting enzyme genotypes in older hypertensive individuals显示文摘	ZEE R Y SCHRADER A P	1994	J Clin Invest1994，94，3：	1
19	Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decaypathway显示文摘	Schrader R Young C Kozian D	2006	J Biol Chem2006，281，35：	1
20	A novel strategy for generating monoclonal antibodies from single,isolated lymphocytes producing antibodies of defined specificities显示文摘	Babcook J S Leslie K B Olsen O A Salmon R A Schrader J W	1996	Proc Natl Acad Sci USA1996，93，：	1

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