| 7 | Secretoneurin和神经原性炎症(英文)显示文摘AIM: Review of evidence that the 33-amino-acidpolypeptide secretoneurin, which is generated byproteolytic cleavage of secretogranin Ⅱ, plays a role inneurogenic inflammation. METHODS: Survey of theliterature using a MEDLINE search database. RE-SULTS: Secretoneurin is synthesized in spinalganglia, transported through the dorsal roots and storedin the axon terminals of primary afferent neurons.Investigations using capsaicin suggest that secretoneurinfunctions as an excitatory transmitter. Secretoneurinspecifically activates various cell functions including thechemotactic migration of monocytes, eosinophils,fibroblasts, smooth muscle cells, and endothelial cells, | Christian J WIEDERMANN Stefan DUNZENDORFER Christian M K■HLER Norbert REINISCH Peter SCHRATZBERGER | 1999 | 中国药理学报1999，20，9： | 1 |
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