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| 1 | Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease显示文摘AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up study.Initially,three gastroplications using the Endocinch device were placed under deep sedation in a standardized manner.Optional retreatment was offered in the first year with 1 or 2 extra gastroplications.At baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using > 50% of their baseline PPI dose or receiving alternative antireflux therapy) were assessed.Intention-to-treat analysis was performed.RESULTS:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to follow-up.In 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events occurred.At the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P < 0.01compared to baseline).However,80% of patients required PPIs for their GERD symptoms.Ultimately,64% of patients were classified as treatment failures.In 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was diagnosed.CONCLUSION:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually. | Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 2 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 3 | Ein gezielter aufbau des chlorinsystems显示文摘 | Montforts F P Schwartz U M | 1985 | Liebigs Ann Chem1985，，： | 2 |
| 4 | Totalsynthese yon ( + / - ) bonellindimethylester显示文摘 | Montforts F P Schwartz U M | 1991 | Liebigs Ann Chem1991，，： | 2 |
| 5 | Genetic variants of platelet glycoprotein receptors and risk of stroke in young women 显示文摘 | Reiner A P Kumar P M Schwartz S M | 2000 | Stroke2000，31，7： | 1 |
| 6 | A mutant form of maltose-binding protein of Escherichia coli deficient in its interaction with the bacteriophage lambda receptor protein显示文摘 | Bavoil P Wandersman C Schwartz M | 1983 | Bacteriology1983，155，： | 1 |
| 7 | Alternate estrogen re- ceptors promote invasion of inflammatory breast cancer cells via non- genomic signaling显示文摘 | Ohshiro K Schwartz A M Levine P H | 2012 | PLoS One2012，7，30： | 1 |
| 8 | Culturing of calcium stable adult cardiac myocytes显示文摘 | PIPER H M PROBST I SCHWARTZ P | 1982 | J Mol Cell Cardiol1982，14，： | 1 |
| 9 | Preven tion of sudden cardiac death after a first myocardial infarction by pharmacologic or surgical antiadrenergic interventions显示文摘 | SCHWARTZ P J MOTOLESE M POLLAVINI G | 1992 | J Cardiovase Electrophysiol1992，3，： | 1 |
| 10 | Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary显示文摘 | TANGIR T ZELTERMAN D M W SCHWARTZ P E | 2003 | Obstet Gynecol2003，101，： | 1 |
| 11 | Characterization of fat-storing cell lines derived from normal and CCI4-cirrhotic livers: Differences in the production of Interleukin-6显示文摘 | Greenwel P Schwartz M Rosas M | 1991 | Lab Invest1991，65，6： | 1 |
| 12 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 13 | Tensile properties of triaxially woven fabric under biaxial loading 显示文摘 | SCHWARTZ P FOMES R E MOHAMED M H | 1980 | Journal of Manufacturing Science and Engineering1980，102，4： | 1 |
| 14 | Radiosurgery with unflattened 6 MV photon beams 显示文摘 | O'BRIEN P F GILLIES B A SCHWARTZ M | 1991 | Med Phys1991，18，3： | 1 |
| 15 | High efficacy of β-blocker in long-QT syndrome type I显示文摘 | VINCENT G M SCHWARTZ P J DENJOY I | 2009 | Circulation2009，119，： | 1 |
| 16 | Small-molecule inhibitors of Bcl-2 显示文摘 | Manion M K Fry J Schwartz P S | 2006 | Curr Opin Investig Drugs2006，7，12： | 1 |
| 17 | An analysis of the mechanical behavior of triaxial fabrics and the equivalency of conventional fabrics 显示文摘 | SCHWARTZ P FOMES R E MOHAMED M H | 1982 | Textile Research Journal1982，52，6： | 1 |
| 18 | NF-кB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome显示文摘 | MOINE P MclNTYRE R SCHWARTZ M D | 2000 | Shock2000，13，2： | 1 |
| 19 | Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2 显示文摘 | ALAVI K SCHWARTZ M Z PALAZZO J P | 2000 | Journal of Pediatric Surgery2000，35，6： | 1 |
| 20 | The effects of base dopant outdiffusion and undoped Si1-x Gex junction spacer layers in Si/Si1-x Gex/Si heterojunction bipolar transistors 显示文摘 | Prinz E J Garone P Schwartz M | 1991 | IEEE Elec Dev Lett1991，12，2： | 1 |
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