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| 1 | Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies显示文摘AIM To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma.METHODS Pub Med and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein(CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-a) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios(ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of heterogeneity.RESULTS A total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary(OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, P heterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma(OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, P heterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-a and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00(95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19(95%CI: 0.92-1.55).CONCLUSION Summary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated. | Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso | 2017 | World Journal of Gastroenterology2017，23，10： | 5 |
| 2 | The role of insulin receptors and IGF-I receptors in cancer and other diseases 显示文摘 | Frasca F Pandini G Sciacca L | 2008 | Arch Physiol Biochem2008，114，1： | 1 |
| 3 | Insulin receptor isoform A and insulin-like growth factor Ⅱ as additional treatment targets in human osteosarcoma显示文摘 | Avnet S Sciacca L Salerno M | 2009 | Cancer Res2009，69，6： | 1 |
| 4 | The role of insulin receptors and IGF- I receptors in cancer and other di- seases显示文摘 | Frasca F Pandini G Sciacca L | 2008 | Arch Physiol Biochem2008，114，1： | 1 |
| 5 | Diabetes and cancer显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 6 | Determinants of left ventricular thrombus formation after primary percutaneous coronary intervention for anterior wall myocardial infarction显示文摘 | Rabbani L E Waksmonski C Iqbal S N Stant J Sciacca R Apfelbaum M | 2008 | J Thromb Thrombolysis2008，25，： | 1 |
| 7 | Diabetes and cancer显示文摘 | Vigneri P Frasea F Sciacca L | 2009 | Endoer RelatCancer2009，16，4： | 1 |
| 8 | A novel autecreine loop invoMng IGF2 and the insulin receptor isoformA stimulates growth of thyroid cancer显示文摘 | Vella V Pandini G Sciacca L | 2002 | J Clin Endocrinol Metab2002，87，1： | 1 |
| 9 | Diabetes and cancer 显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 10 | Insulin and its analogs: actions via insulin and IGF receptors 显示文摘 | Vigeri R Squtrito S Sciacca L | 2010 | Acta Diabetol2010，47，： | 1 |
| 11 | Diabetes and cancer显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 12 | Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease显示文摘 | Belfiore A Frasca F Pandini G Sciacca L Vigneri R | | 0，，： | 1 |
| 13 | Bearings-Only Tracking Using Hidden Models显示文摘 | Logothetis A Evans R J Sciacca L J | 1998 | Proceedings of the 3ard Conference on Decision and Control1998，，4： | 1 |
| 14 | Diabetes and cancer显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 15 | Diabetes and cance显示文摘 | Vigneri P Frasca F Sciacca L et a1 | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 16 | ASPBI0 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-1 receptor显示文摘 | Milazzo G Sciacca L Papa V | 1997 | Mol Carcinog1997，18，1： | 1 |
| 17 | Diabetes and cancer显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 18 | Diabetes and cancer显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocrine-related cancer2009，16，4： | 1 |
| 19 | Diabetes and cancer显示文摘 | VIGNERI P FRASCA F SCIACCA L | 1960 | Endocr Relat Cancer1960，16，4： | 1 |
| 20 | Diabetes and cancer显示文摘 | Vignen P Frasca F Sciacca L | 2009 | Diabetes and cancer2009，16，4： | 1 |
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