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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 3 | Volumetric Analysis Predicts Hepatic Dysfunction in Patients Undergoing Major Liver Resection显示文摘 | Margo Shoup Mithat Gonen Michael D’Angelica William R Jarnagin Ronald P DeMatteo Lawrence H Schwartz Scott Tuorto Leslie H Blumgart Yuman Fong | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
| 4 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 7 | Fatty acid composition of adipose tissue from lean and obese swine 显示文摘 | SCOTT R A CORNELIUS S G MERSMANN H J | 1981 | Journal of Animal Science1981，53，： | 1 |
| 8 | A rate-limiting role for dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody显示文摘 | Glantschnig H Scott K Hampton R | | 0，，02： | 1 |
| 9 | In utero exposure to di (n-butyl) phthalate and testicular dys- genesis: comparison of fetal and adult end points and their dose sensitivity 显示文摘 | Mahood I K Scott H M Brown R | 2007 | Environ Health Perspect2007，115，： | 1 |
| 10 | Peer Counseling 显示文摘 | Scott S H Warner R W | 1974 | Personnel and Guidance Journal1974，，53： | 1 |
| 11 | Coniunctival instillation of scrapie in mice can produce disease显示文摘 | Scott J R Foster J D H Fraser | 1993 | Veterinary Microbiolgy1993，34，： | 1 |
| 12 | Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss 显示文摘 | McMillan D C Watson W S Scott H R | 2001 | Nutr Cancer2001，39，2： | 1 |
| 13 | Cracking and Deformation of Axially Reinforced Members Subjected to Pure Tension 显示文摘 | Beeby A W Scott R H | 2005 | Magazine of Concrete Research2005，57，10： | 1 |
| 14 | Facts and recommendations about total homocysteine determinations:an expert opinion显示文摘 | Refsum H Smith A D Ueland P M Nexo E Clarke R McPartlinJ Johnston C Engbaek F SchneedeJ McPartlin C Scott J M | 2004 | Clinical Chemistry2004，50，1： | 1 |
| 15 | Improving water flood recovery of viscous crude oils by chemical control显示文摘 | Scott G R Collins H N Flock D L | 1965 | J Can Petrol Technol1965，4，4： | 1 |
| 16 | Effect of p-glycoprotein on the parmacokinetics and tissue distribution of enaminone anticonvulsants analysis by populatin and physiological approaches显示文摘 | Cox D S Scott H R Gao H | 2002 | J pharmacel EXP Ther2002，302，： | 1 |
| 17 | Foundry air contaminants from green sand molds显示文摘 | SCOTT W D JAMES R H BATES C E | 1976 | Am Ind Hyg Assoe J1976，37，： | 1 |
| 18 | Intravaginal and intrarectal screening of antimitotic drugs for topical effectiveness显示文摘 | Bonder R H | 1971 | J Invest Dermatol1971，56，： | 1 |
| 19 | The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer 显示文摘 | Scott H R McMillan D C Forrest L M | 2002 | BrJ Cancer2002，87，3： | 1 |
| 20 | Farm Technology andTechnical Efficiency:Evidence from Four Regions in China显示文摘 | Chen Zhuo Wallace E H Scott R | 2009 | China Economic Review2009，，20： | 1 |
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