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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | A new Early Cretaceous dinosaur track assemblage and the first definite non-avian theropod swim trackway from China显示文摘The trackway of a swimming theropod (ichnogenus Characichnos) is reported from the Lower Cretaceous Feitianshan Formation of Sichuan, China. These swim tracks help confirm that non-avian theropods were capable of forging moderately deep bodies of water. The trackway occurs on the same surface as a typical walking trackway of a sauropod (ichnogenus Brontopodus). Both occurrences are the first reported from the Cretaceous of Sichuan, and the swim tracks are the first well-preserved example of a Characichnos trackway from China. Additionally, a theropod walking trackway and several ornithopod walking trackways (similar to the ichnogenus Caririchnium) occur in the same horizon. The ornithopod trackways show a parallel orientation, suggesting gregarious behavior of the trackmakers, which may have been iguanodontiforms and/or hadrosauriforms. The co-occurrence of theropod swim tracks and theropod walking tracks suggests a fluctuation of water depth within a distinct time span. | XING LiDa LOCKLEY Martin G ZHANG JianPing MILNER Andrew R C KLEIN Hendrik LI DaQing PERSONS IV W Scott EBI JieFang | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 3 | The efficacy of spinosad against the western flower thrips,Frankliniella occidentalis,and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Jones T Scott D C Harris R | 2005 | Pest Manag Sci2005，61，： | 1 |
| 4 | T lymphocyte subpopulations in idiopathic thrombocytopenic purpura (ITP) 显示文摘 | Scott C S Wheeler R Ford P | 1983 | Scand J Haematol1983，40，： | 1 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Randomized phase III study comparing best supportive care to Biafine as a pro- phylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13显示文摘 | Fisher J Scott C Stevens R | 2000 | lnt J Radiat Oncol BiolPhys2000，48，5： | 1 |
| 7 | PKI Elliptic Curve Cryptography,and Digital Signatures显示文摘 | William J C Edward P D Scott A R | 1999 | Computers and Security1999，18，： | 1 |
| 8 | Development of coarsegrained facies in lacustrine rift basins, example from East of America 显示文摘 | Scholz C A Rosendahl B R Scott D L | 1990 | Geology1990，18，2： | 1 |
| 9 | A physically based,non-dimensional parameter for discriminating between locations of freezing rain and ice pellets显示文摘 | Czys R R Scott R W Tang K C | | 0，，04： | 1 |
| 10 | The importance of cadmium as a factor in calcified upper urinary tract stone disease- A prospective 7-year study 显示文摘 | Scott R Cunningham C Lelland | 1982 | Br J Urol1982，54，6： | 1 |
| 11 | GeoIRIS:geospatial information retrieval and indexing system-content mining,semantics modeling,and complex Queries显示文摘 | Shyu C R Klaric M Scott G J | 2007 | IEEE Trans on Geoscience and Remote Sensing2007，，4： | 1 |
| 12 | Randomised phase III study comparing best supportive care to biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: radiation therapy oncology group显示文摘 | Fisher J Scott C Stevens R | 2000 | Int J Radiat Oncol Biol Phys2000，48，5： | 1 |
| 13 | percutaneous transthoraeic needle aspiration biopsy:a comprehensive review of its current role in the diagnosis and treatment of lung lumors显示文摘 | Larseheid R C Thorpe P E Scott W J | 1998 | Chest1998，114，3： | 1 |
| 14 | GeolRIS: Geospatial Information Retrieval and Indexing Sys- tem-content Mining, Semantics Modeling, and Complex Queries显示文摘 | Shyu C R Klarie M Scott G J | 2007 | IEEE Transactions on Geo- sciences and Remote Sensing2007，45，83： | 1 |
| 15 | Improving tourism destination governance:a complexity science approach显示文摘 | Baggio R SCOTT N COOPER C | | 0，，04： | 1 |
| 16 | Destination networks: four Aus- tralian cases 显示文摘 | Scott N Cooper C Baggio R | 2008 | Annals of Tourism Research2008，35，1： | 1 |
| 17 | Electroencephalographic quantitation of opioid effect:Comparative pharmacodynamics of fentanyl and sufentanil显示文摘 | SCOTT J C COOKE J E STANSKI D R | 1991 | Anesthesiology1991，74，1： | 1 |
| 18 | Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss 显示文摘 | McMillan D C Watson W S Scott H R | 2001 | Nutr Cancer2001，39，2： | 1 |
| 19 | Herbicidal activity on acetolactate synthase-resistant barnyardgrass (Echinochloa crus-galli) in Arkansas, USA 显示文摘 | Norsworthy J K Wilson M J Scott R C | 2014 | Weed Biology and Management2014，14，1： | 1 |
| 20 | Network Science: A Review Fo- cused on Tourism 显示文摘 | Baggio R Scott N Cooper C | 2010 | Annals of Tourism Research2010，37，3： | 1 |
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