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| 1 | Pathophysiology of cerebral oedema in acute liver failure显示文摘Cerebral oedema is a devastating consequence of acute liver failure(ALF)and may be associated with the development of intracranial hypertension and death.In ALF,some patients may develop cerebral oedema and increased intracranial pressure but progression to lifethreatening intracranial hypertension is less frequent than previously described,complicating less than one third of cases who have proceeded to coma since the advent of improved clinical care.The rapid onset of encephalopathy may be dramatic with the development of asterixis,delirium,seizures and coma.Cytotoxic and vasogenic oedema mechanisms have been implicated with a preponderance of experimental data favouring a cytotoxic mechanism.Astrocyte swelling is the most consistent neuropathological finding in humans with ALF and ammonia plays a definitive role in the development of cytotoxic brain oedema.The mechanism(s)by which ammonia induces astrocyte swelling remains unclear but glutamine accumulation within astrocytes has led to the osmolyte hypothesis.Current evidence also supports an alternate‘Trojan horse’hypothesis,with glutamine as a carrier of ammonia into mitochondria,where its accumulation results in oxidative stress,energy failure and ultimately astrocyte swelling.Although a complete breakdown of the blood-brain barrier is not evident in human ALF,increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions.At present,there is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects our incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown. | Teresa R Scott Victoria T Kronsten Robin D Hughes Debbie L Shawcross | 2013 | World Journal of Gastroenterology2013，19，48： | 8 |
| 2 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 3 | Outcome of cytomegalovirus infections in patients with inflammatory bowel disease显示文摘 | Konstantinos A Papadakis Jim K Tung Scott W Binder Lori Y Kam Maria T Abreu Stephan R Targan Eric A Vasiliauskas | 2001 | The American Journal of Gastroenterology2001，，7： | 2 |
| 4 | The efficacy of spinosad against the western flower thrips,Frankliniella occidentalis,and its impact on associated biological control agents on greenhouse cucumbers in southern Ontario显示文摘 | Jones T Scott D C Harris R | 2005 | Pest Manag Sci2005，61，： | 1 |
| 5 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 6 | Larvicidal effica- cy of nitenpyram on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs 显示文摘 | Correia T R Scott F B Verocai G G | 2010 | Vet Parasitol2010，173，： | 1 |
| 7 | A study on the interaction of xylanase and phytase enzymes in wheat-based diets fed to commercial white and brown egg laying hens 显示文摘 | Silversides F G Scott T A Korver D R | 2006 | Poultry Science2006，85，： | 1 |
| 8 | Total knee arthroplasty with the PFC system results at a minimum of ten years and survivorship analysis 显示文摘 | Schai P A Thornhill T S Scott R D | 1998 | J Bone Joint Surg Br1998，80，5： | 1 |
| 9 | Effect of prone position on regional shunt,aeration,and perfusion in experimental acute lung injury显示文摘 | Richter T Bellani G Scott Harris R | | 0，，： | 1 |
| 10 | The vapor pressures of the deuteromethanes显示文摘 | Armstrong G T Brickwedde F G Scott R B | 1953 | J Chem Phys1953，21，7： | 1 |
| 11 | Underwater orbital TIG welding显示文摘 | Scott Lyons R Middleton T B | 1985 | Metal Construction1985，5，8： | 1 |
| 12 | Nanoscale zero-valent iron: future prospects for an emerging water treatment technology显示文摘 | Crane R A Scott T B | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 13 | Cleaning up clostridium difficile infection显示文摘 | Matthew R T Scott C L Douglas R | 2002 | Mayo Clin Proc2002，76，9： | 1 |
| 14 | An analysis of crack pattern in clay soil: its density and orientation显示文摘 | | 1986 | J Soil Sci1986，37，： | 1 |
| 15 | The effect of different routes of antigen administration on the humoral immune response of the chick 显示文摘 | Van der Zijpp Scott T R Glick B | 1986 | Poultry Sci1986，65，： | 1 |
| 16 | On the stability of the FDTD algorithm for elastic media at a material interface 显示文摘 | Schrder C T Scott W R | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，2： | 1 |
| 17 | Prognostic assessment of ovarian reserve显示文摘 | SCOTT R T Jr HOFMANN G E | 1995 | Fertil Steril1995，63，1： | 1 |
| 18 | Removal of Irora from Leach Liquors by the 'Goethite' Process 显示文摘 | Davey P T Scott T R | 1976 | Hydrometallurgy1976，2，1： | 1 |
| 19 | Granuloma annttlare-another manifestation of Bartonella infection? 显示文摘 | Smoller B R Madhusudhan K T Scott M A ct al | 2001 | Am J Dermatol2001，23，： | 1 |
| 20 | Simulation, fabrication and testing of Bulk Micromachined 6H-SiC High-g Piezoresistive Accelerometer 显示文摘 | Andrew R Atwelll Robert S Okojie Kevin T Kornegay Scott L Roberson Alain Beliveau | 2003 | Sensors and Actuators A: Physics (S0924-4247)2003，104，1： | 1 |
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