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| 1 | Immunopathogenesis of inflammatory bowel disease显示文摘Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. | David Q Shih Stephan R Targan | 2008 | World Journal of Gastroenterology2008，14，3： | 44 |
| 2 | Immunogenetic phenotypes in inflammatory bowel disease显示文摘当前接受的 etiopathogenic 假设建议长期的肠的发炎和煽动性的肠疾病(IBD ) 的相关全身的表明特征由于对居民钠的过分好攻击或病理学的有免疫力的回答细菌的成分。预先安排的因素是粘膜免疫者回答或障碍功能的基因 dysregulation,与环境刺激触发的发作。这些因素和他们的相互作用可以也是疾病显型和疾病前进的重要决定因素。免疫的出现基因显型把支持借给不同免疫者处理的危险性基因调整的建议假设,由钠抗原开车,表示了接着在 IBD 影响临床的显型的同样特定的有免疫力的显型病人。 | Maria C Dubinsky Kent Taylor Stephan R Targan Jerome I Rotter | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 3 | A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease显示文摘Small bowel tumors and Crohn's disease are common causes of small bowel obstruction.Early stage neoplasms can easily be mistaken for Crohn's disease.Therefore,thorough work-ups including imaging studies and endoscopic evaluation with biopsies are critical for accurate diagnosis.Here we report a case of an otherwise healthy female with progressive onset of multiple,recurrent obstructive symptoms secondary to terminal ileal narrowing who was referred for management of steroid-dependent Crohn's disease.After thorough evaluation,the diagnosis was revised to myeloid granulocytic sarcoma involving the terminal ileum.In this case,a delay in diagnosis can be detrimental for prognosis,as myeloid granulocytic sarcoma is highly predictive of underlying acute myeloid leukemia and needs urgent referral for chemotherapy and/or resection. | Lola Y Kwan Stephan R Targan David Q Shih | 2011 | World Journal of Gastroenterology2011，17，19： | 3 |
| 4 | Antibodies to CBir1 Flagellin Define a Unique Response That Is Associated Independently With Complicated Crohn’s Disease显示文摘 | Stephan R. Targan Carol J. Landers Huiying Yang Michael J. Lodes Yingzi Cong Konstantinos A. Papadakis Eric Vasiliauskas Charles O. Elson Robert M. Hershberg | 2005 | Gastroenterology2005，，： | 2 |
| 5 | Outcome of cytomegalovirus infections in patients with inflammatory bowel disease显示文摘 | Konstantinos A Papadakis Jim K Tung Scott W Binder Lori Y Kam Maria T Abreu Stephan R Targan Eric A Vasiliauskas | 2001 | The American Journal of Gastroenterology2001，，7： | 2 |
| 6 | Tumor necrosis factor: Biology and therapeutic inhibitors显示文摘 | Konstantinos A. Papadakis Stephan R. Targan | 2000 | Gastroenterology2000，，4： | 2 |
| 7 | Insights into IBD pathogenesis显示文摘 | David Q. Shih Stephan R. Targan | 2009 | Current Gastroenterology Reports2009，，6： | 2 |
| 8 | Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease显示文摘 | Ruemmele F M Targan S R Levy G | 1998 | Gastroenterology1998，115，4： | 1 |
| 9 | Role of cytokines in the pathogenesis of inflammatory bowel disease显示文摘 | Papadakis KA Targan SR | 2000 | Annu Rev Med2000，51，2： | 1 |
| 10 | Recent advances in IBD pathogenesis: Genetics and immunobiology显示文摘 | David Q. Shih Stephan R. Targan Dermot McGovern | 2008 | Current Gastroenterology Reports2008，，6： | 1 |
| 11 | Role of cytokines in the pathogenesis of inflammatory bowel disease显示文摘 | Papadakis KA Targan SR | 2000 | Annu Rev Med2000，51，： | 1 |
| 12 | Tumor necrosis factor: biology and therapeutic inhibitors 显示文摘 | Papadakis KA Targan SR | 2000 | Gastroenterology2000，119，4： | 1 |
| 13 | Abatacept for Crohn’s Disease and Ulcerative Colitis显示文摘 | William J. Sandborn Jean–Frederic Colombel Bruce E. Sands Paul Rutgeerts Stephan R. Targan Remo Panaccione Brian Bressler Karl Geboes Stefan Schreiber Richard Aranda Sheila Gujrathi Allison Luo Yun Peng Luisa Salter–Cid Stephen B. Hanauer | 2012 | Gastroenterology2012，，1： | 1 |
| 14 | Selected loss of tolerance evidenced by Crohn’s disease–associated immune responses to auto- and microbial antigens显示文摘 | Carol J. Landers Offer Cohavy Rajeev Misra Huiying Yang Ying–Chao Lin Jonathan Braun Stephan R. Targan | 2002 | Gastroenterology2002，，： | 1 |
| 15 | Tumor necrosis factor:biology and therapeutic inhibitors显示文摘 | Papadakis KA Targan SR | 2000 | Gastroenterology2000，11，4： | 1 |
| 16 | Serologictestingininflammatoryboweldisease:itsvalueinindeterminatecolitis显示文摘 | Papadakis KA Targan SR | 1999 | CurGastroenterolRep1999，1，： | 1 |
| 17 | High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis显示文摘 | TARGAN S R LANDERS C VIDRICH A | 1995 | Gstroenterology1995，108，4： | 1 |
| 18 | Tumor necrosis factor: biology and therapeutic inhibitors显示文摘 | Papadakis KA Targan SR | 2000 | Gastroenterology2000，119，： | 1 |
| 19 | A Short -term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor Al- pha for Crohn's Disease cA2 Study Group显示文摘 | Targan SR Hanauer SB Van Deventer SJ | 1997 | N Engl J Med1997，337，： | 1 |
| 20 | High titer antineutrophil cytoplasmic antibodies in type - Ⅰ autoimmune hepatitis 显示文摘 | Targan SR Landers C Vidrich A | 1995 | Gastroenterology1995，108，4： | 1 |
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