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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | Laparoscopic staging for gastric cancer显示文摘 | Mansfield PF Leach SD | 1996 | Surgery1996，119，： | 1 |
| 3 | Comparision of multislice computed tomography and endoscopic ultrasonography with opera-tive and histological findings in suspected pancreatic and periampullary malignancy显示文摘 | Mansfield SD Scott J Oppong K | 2008 | Br J Surg2008，95，12： | 1 |
| 4 | Optimization of SO2-catalyzed steam pretreatment of corn fiber for ethanol production 显示文摘 | Bura R Bothast RJ Mansfield SD | 2003 | Appl Biochem Biotechnol2003，，： | 1 |
| 5 | Fast-track management of patients undergoing proximal pancreatic resection显示文摘 | French JJ Mansfield SD Jaques K | 2009 | Ann R Coil Surg Engl2009，91，3： | 1 |
| 6 | Response to neo- adjuvant chemotherapy best predicts survival after curative resection of gastric cancer显示文摘 | Iwy AM Mansfield PF Leach SD | 1999 | Arm Surg1999，229，3： | 1 |
| 7 | Fast-track management of patients undergoing proximal pancreatic resection显示文摘 | French JJ Mansfield SD Jaques K | 2009 | Ann R Coll Surg Engl2009，91，3： | 1 |
| 8 | Fast-track manage- ment of patients undergoing proximal pancreatic resection 显示文摘 | French JJ Mansfield SD Jaques K | 2009 | Ann R Coll Surg Engl2009，91，3： | 1 |
| 9 | Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer 显示文摘 | Lowy AM Mansfield PF Leach SD | 1999 | Ann Surg1999，229，3： | 1 |
| 10 | The effect of initial pore volume and lignin content on the enzymatic hydrolysis of softwoods显示文摘 | Mooney CA Mansfield SD Touhy MG | 1998 | Bioresource Technology1998，64，2： | 1 |
| 11 | Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer显示文摘 | Lowy AM Mansfield PF Leach SD | 1999 | Ann Surg1999，229，3： | 1 |
| 12 | Response to neoadju- vant chemotherapy best predicts survival after curative resection of gastric cancer显示文摘 | Lowy AM Mansfield PF Leach SD | 1999 | Ann Surg1999，229，3： | 1 |
| 13 | Comparison of muhislice computed tomography and endoscnpic ultrasonography with operalive and histological findings in suspected pancreatic and periampullary malignancy显示文摘 | Mansfield SD Scott J Oppong K | 2008 | Br J Surg2008，95，12： | 1 |
| 14 | Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer 显示文摘 | Lowy AM Mansfield PF Leach SD | 1999 | Ann Surg1999，229，3： | 1 |
| 15 | Comparison of mul-tislice computed tomography and endoscopic ultrasonography with operative and histological findings in suspected pancreatic and periampullary malignancy显示文摘 | Mansfield SD Scott J Oppong K | 2008 | Br J Surg2008，95，12： | 1 |
| 16 | Response to neoadjuvant chemotherapy best predicts survival after curative resection for gastric cancer显示文摘 | Lowy AM Mansfield PF Leach SD | 1999 | Ann Surg1999，229，3： | 1 |
| 17 | Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer 显示文摘 | Lowy AM Mansfield PF Leach SD etal | 1999 | Ann Surg1999，229，3： | 1 |
| 18 | Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer 显示文摘 | Lowy AM Mansfield PF Leach SD | 1999 | Ann Surg1999，229，3： | 1 |
| 19 | Comparison of multislice computed tomography and endoscopic ultrasonography with operative and histological findings in suspected pancreatic and periampullary malignancy 显示文摘 | Mansfield SD Scott J Oppong K | 2008 | Br J Surg2008，95，12： | 1 |
| 20 | Laparoscopic staging for gastric cancer 显示文摘 | Lowy AM Mansfield PF Leach SD | 1996 | Surgery1996，119，6： | 1 |
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