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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Static and quasi-dynamic load balancing in parallel FDTD codes for signal integrity, power integrity and packaging applications 显示文摘 | S A Seguin M A Cracraft J L Drewniak | 2004 | Electromagnetic Compatibility2004，1，： | 1 |
| 3 | An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition显示文摘 | Seguin L Kato S Franovic A | 2014 | Nat Cell Biol2014，16，5： | 1 |
| 4 | Non -traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia显示文摘 | Seguin C Kassis J Busque L | 2008 | Rheumatology (Oxford)2008，47，8： | 1 |
| 5 | Insitu Structural Study of 4V-Range Lithium Extration/insertion in Fluoeine-Substituted LiMn2O4 显示文摘 | Palacin M R Cras F L Seguin L etal | 1999 | J Solid State Chemistry1999，144，： | 1 |
| 6 | NiTi thin films as a gate of M0S capacity sensors显示文摘 | Bendahan M Aguir K Seguin J L | 1998 | Sensors and Actuators1998，74，1： | 1 |
| 7 | An integrin 153-KRAS-RalB complex drives turnout sternness and resistance to EGFR inhibition 显示文摘 | Seguin L Kato S Franovic A | 2014 | Nat Cell Biol2014，16，5： | 1 |
| 8 | Urological complications of laparoscopic surgery:experience with 350 procedures at a single center显示文摘 | Soulie M Seguin P Richeux L | 2001 | J Urol2001，165，： | 1 |
| 9 | Price Volatility Volume ,and Market Depth: Evidence from Futures Markets显示文摘 | Seguin P L | 1993 | Journal of Financial and Quantitative Analysis1993，29，： | 1 |
| 10 | Transaction costs and price volatility: Evidence from commission deregulation 显示文摘 | Jones C M and Seguin P L | 1997 | American Economic Review1997，87，72： | 1 |
| 11 | New type of schottky barriers using NiTi shape memory alloy films显示文摘 | Bendahan M Seguin J L Lollman D at el | 1997 | Thin Solid Films1997，294，12： | 1 |
| 12 | Price volatility volume,and market depth:evidence from futures markets显示文摘 | Bessembinder H Seguin P L | 1993 | Jounral of Financial and Quantitative Analysis1993，29，： | 1 |
| 13 | Comparison of plan- tar pressures and contact area between normal and cavus foot显示文摘 | Fernandez - Seguin L M Mancha J A D Rodriguez RS | 2014 | Gait Posture2014，39，2： | 1 |
| 14 | Multi-institutional study of complications in 1085 laparoscopic urologic procedures 显示文摘 | Soulie M Salomon L Seguin P | 2001 | Urology2001，58，6： | 1 |
| 15 | Integrinαvβ3drives slug activation and stemness in the pregnant and neoplastic mammary gland显示文摘 | Desgrosellier JS Lesperance J Seguin L | 2014 | Dev Cell2014，30，3： | 1 |
| 16 | Expression of the green fluorescent protein gene in conifer tissues显示文摘 | Tian L Seguin A and Charest PJ | 1997 | Plant Cell Report1997，16，： | 1 |
| 17 | Death on the battlefield(2001-2011):implications for the future of combat casualty care显示文摘 | EASTRIDGE B J MABRY R L SEGUIN P | 2012 | J Ttauma Acute Care Surg2012，73，5： | 1 |
| 18 | The Contribution of 'Cool' and 'Hot' Components of Decision - Making in Adolescence: Implications for Developmental Psychopathology 显示文摘 | Seguin J R Arseneauh L Tremblay R E | 2007 | Cognitive Development2007，22，4： | 1 |
| 19 | Death on the battlefield(2001-2011):implication for the future of combat casualty care显示文摘 | Eastridge B J Mabry R L Seguin P | | 0，，6： | 1 |
| 20 | Stress pathways to spontaneous preterm birth : the role of stressors, psychological dis- tress, and stress hormones显示文摘 | KRAMER M S LYDON J SEGUIN L | 2009 | Am J Epidemiol2009，169，11： | 1 |
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