| 1 | Calcium supplementation in colorectal cancer prevention:A systematic meta-analysis of adverse events显示文摘Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer,most of the associated adverse effects are not systematically analyzed.The aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic meta-analysis.We searched Medline,PubMed Central,EMBASE(Excerpta Medica database),Scopus,Cochrane Central Register of Controlled Trials,and Web of Science published in English from database inception up to 31 July 2019.In the current systematic meta-analysis,we included human studies(including cohort studies,clinical trials,case-control studies)on supplementation of calcium in patients with or at risk of colorectal cancer.Assessment of the quality of included studies was performed by Jadad score.Information on the patient population,number of enrolled subjects in each group,dose of calcium supplementation,duration of calcium supplementation,and reported adverse events were gathered.The data were pooled for incidence rates for any adverse event during the study period regardless of causality association.We identified 6 studies,comprising 4583 participants that met the inclusion criteria.Meta-analysis on pooled incidence rates for adverse event during study period showed no statistically significant increased risk for cancer(OR=0.92,95%CI:0.70–1.21,P=0.577;I^(2)=0.0%,P=0.731),coronary revascularization(OR=1.12,95%CI:0.79–1.59,P=0.492;I^(2)=0.0%,P=0.957),myocardial infarction(OR=0.81,95%CI:0.34–1.91,P=0.634;I^(2)=67.9%,P=0.047),stroke(OR=0.75,95%CI:0.42–1.33,P=0.332,I^(2)=0.00%,P=0.717),Transient Ischemic Attack(TIA)(OR=1.37,95%CI:0.28–6.51,P=0.692,I^(2)=81.9%,P=0.002),urolithiasis(OR=1.23,95%CI:0.75–2.01,P=0.410;I^(2)=0.0%,P=0.851),fracture(OR=0.98,95%CI:0.70–1.37,P=0.938;I^(2)=37.8%,P=0.152)and death(OR=1.05,95%CI:0.71–1.56,P=0.786,I^(2)=12.2%,P=0.317)in patients receiving calcium supplementation for colorectal cancer prevention compared to control.Based on the results of Egger test,publication bias was not observed among the studies(P=0.262).The current result of the meta-analysis on human studies reporting adverse events associated with calcium supplementation for the prevention of colorectal cancer demonstrated no statistically significant increased risk for the development of adverse events compared to control groups. | XUE MEI LUO SHAHANAVAJ KHAN ABDUL MALIK FAHAD M.ALDAKHEEL ANIS AHMAD CHAUDHARY SHOUKI BAZARBASHI FATEMEH TABATABAIE | 2022 | BIOCELL2022，46，3： | 0 |
| 2 | Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development显示文摘Available reports have confirmed a link between bacterial infection and the progression of different types of cancers,including colon,lungs,and prostate cancer.Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum(ER)using in-silico approaches and their possible role in lung cancer etiology.We predicted 48 proteins that target human ER,which may be associated with protein folding and protein-protein interactions during infection.The results showed C.pneumoniae proteins targeting human ER and their implications in lung cancer growth.These targeted proteins may be involved in competitive interactions between host and bacterial proteins,which may change the usual pathway functions and trigger the development of lung cancer.Moreover,C.pneumoniae unfolded protein accumulation in the human ER possibly induces ER stress,consequently activating the unfolded protein response(UPR),and providing a favorable microenvironment for cancer growth.The current study showed the C.pneumoniae protein targeting in ER of host cell and their implication in lung cancer growth.These results may help researchers better manage lung cancer and establish a molecular mechanism for C.pneumoniae lung cancer association. | YANYAN LI SHAHANAVAJ KHAN ANIS AHMAD CHAUDHARY HASSAN AHMED RUDAYNI ABDUL MALIK ASHWAG SHAMI | 2022 | BIOCELL2022，46，1： | 0 |
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