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| 1 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 2 | Crossed-pin Versus Lateral- Pin Fixation in Pediatric Supra con dylar Fractures 显示文摘 | Shams u d din S A Pena fort R Sharaf I | | Med J Malaysia0，200，56： | 1 |
| 3 | Metastatic bone disease as seen in our clinical practice-experience at a tertiary care cancer center in Pakistan显示文摘 | QURESHI A SHAMS U AKHTER A | 2012 | Asian Pac J Cancer Prey2012，13，9： | 1 |
| 4 | Three-year follow-up of posterior capsule opacification with two different silicone intraocular lenses 显示文摘 | Sundelin K Shams H Stenevi U | 2005 | Acta Ophthalmol Stand2005，83，1： | 1 |
| 5 | On the meaning of the degree of milling of rice显示文摘 | Shams U D M Bhattaeharya K R | 1978 | International Journal of Food Science & Technology1978，13，2： | 1 |
| 6 | Sound-induced flash illusion as an optimal percept显示文摘 | Shams L Ma WJ Beierholm U | 2005 | Neuroreport2005，16，17： | 1 |
| 7 | Three-year follow-up of posterior capsule opacification with two different silicone intraacalar lenses显示文摘 | Shams H Stenevi U | 2005 | Acta Ophthalmol Scand2005，83，1： | 1 |
| 8 | Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125 显示文摘 | Ahmed A S Dearn S H Shams M U | 1998 | FASEB1998，10，12： | 1 |
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