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| 1 | Comparison of channel geometry changes in Inner Mongolian reach of the Yellow River before and after joint operation of large upstream reservoirs显示文摘下游的河隧道变化上的水库的影响在最后几十年期间是在河的地形学的一个科学问题。然而,它仍然是至于怎么表示在黄河的内部蒙古的活动范围的隧道调整由在上游的水库的联合操作导致了的份量上的一个困难的问题。在四点在隧道剖面图的形状参数上基于在二个时期在一个泛滥的季节在这个河活动范围计量车站, 19781982 和 20082012 ,现在的工作在隧道剖面图在每个泛滥的季节在一样的控制水水平下面以形状参数变化率调查了隧道变化。结果证明大多数参数的变化率显然在两个时期在一个泛滥的季节增加了。然而,在剖面图的每个参数的变化率在后者时期显然减少了,与以前的时期相比。同时,沿着剖面图的形状参数的变化率的分发模式因此在后者时期在以前的时期从一条凸的曲线改变了到一条塑造 S 的曲线。变化率的明显的减少与 Liujiaxia 和 Longyangxia 水库的联合操作有关。水库存储了大量水并且减少在泛滥的季节的山峰分泌物和最大的速度;作为结果,洪水的侵蚀能力因此减少了。与大水库的联合操作,显著地缩小的内部蒙古的隧道。因此,隧道以后将介绍极端洪水的可能性。因而,在未来调整水库的功能是合理的。在充满季节的全部的水和沉积分泌物和山峰分泌物应该有效地被控制。隧道的连续收缩能因此被避免,它能为潜在的极端洪水准备好了。 | SU Teng WANG Suiji MEI Yanguo SHAO Wenwei | 2015 | Journal of Geographical Sciences2015，25，8： | 5 |
| 2 | Speciated VOC emission inventory and spatial patterns of ozone formation potential in the Pearl River Delta, China 显示文摘 | ZHENG Junyu SHAO Min CHE Wenwei | 2009 | Environ Sci Technol2009，43，22： | 1 |
| 3 | Speciated VOC emission inventory and spatial patterns of ozone forma- tion potential in the Pearl River Delta, China显示文摘 | ZHENG Junyu SHAO Min CHE Wenwei | 2009 | Environmen- tal Science and Technology2009，43，22： | 1 |
| 4 | Speciated VOC emission inventory and spatial patterns of ozone formation potential in the Pearl River Delta, China 显示文摘 | ZHENG Junyu SHAO Min CHE Wenwei | 2009 | Environmental Science & Technology2009，43，22： | 1 |
| 5 | The role of human ADA2a in the regulation of p53 acetylation and stability显示文摘The tumor suppressor protein p53 is a well-known transcription factor that functions as a critical component of the genotoxic stress response via regulating the expression of effector proteins that control cellular fate following DNA damage. The human p300/CBP-associated factor(PCAF)-containing histone acetyltransferase(HAT) complex is important for the stability and activity of p53 via its acetylation. The human homolog of yeast alteration/deficiency in activation 2a(ADA2a) is a stable component of the human PCAF-containing HAT complex. In this study,we demonstrated that p53 and hADA2a physically interact with each other in human HEK 293T cells. Using overexpression and small interfering RNA-mediated knockdown,we demonstrated that hADA2a stabilizes p53 via promoting its acetylation at lysine 320 - a PCAF-dependent acetylation site. Furthermore,hADA2a can potentiate the transcriptional activity of p53 at the BAX and p21 promoters to induce cell apoptosis and cell cycle arrest. Overall,our results establish that hADA2a,a component of the PCAF-containing histone acetyltransferase co-activator complex,is a mediator of acetylation-dependent stabilization and activation of p53 in mammalian cells. | HUANG Jing ZHANG Li XIAO Lin XU LanJun HU FanLei SHAO WenWei LIU Wei MO XiaoNing SHI TaiPing QIU XiaoYan | 2011 | Chinese Science Bulletin2011，56，4： | 1 |
| 6 | Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped RNA betacoronavirus,1 that has spread globally since December 2019.As of July 22,2020,more than 14,000,000 confirmed cases and 607,781 deaths from COVID-19 have been reported to the World Health Organization from 216 areas and territories.2 Patientswithmore prominent laboratory abnormalities may develop acute respiratory distress syndrome(ARDS),which potentially leads tomultiple organ failure and death.1,3 However,at present,there are no regulatory approved antiviralmedicines,vaccines,or specific clinical treatments for COVID-19. | Junping Wu Cherie S.Tan Hongzhi Yu Youwei Wang Yutao Tian Wenwei Shao Yifei Zhang Kuo Zhang Hongxia Shao Guangjian Ni Jun Shen Antonio Carlo Galoforo Qi Wu Dong Ming | 2020 | The Innovation2020，1，3： | 1 |
| 7 | Efficient potential-tuning strategy through p-type doping for designing cathodes with ultrahigh energy density显示文摘Designing new cathodes with high capacity and moderate potential is the key to breaking the energy density ceiling imposed by current intercalation chemistry on rechargeable batteries.The carbonaceous materials provide high capacities but their low potentials limit their application to anodes.Here,we show that Fermi level tuning by p-type doping can be an effective way of dramatically raising electrode potential.We demonstrate that Li(Na)BCF2/L i(Na)B2C2F2 exhibit such change in Fermi level,enabling them to accommodate Li^+(Na^+)with capacities of 290-400(250-320)mAh g^-1 at potentials of 3.4-3.7(2.7-2.9)V,delivering ultrahigh energy densities of 1000-1500 Wh kg^-1.This work presents a new strategy in tuning electrode potential through electronic band structure engineering. | Zhiqiang Wang Da Wang Zheyi Zou Tao Song Dixing Ni Zhenzhu Li Xuecheng Shao Wanjian Yin Yanchao Wang Wenwei Luo Musheng Wu Maxim Avdeev Bo Xu Siqi Shi Chuying Ouyang Liquan Chen | 2020 | National Science Review2020，7，11： | 1 |
| 8 | A study on the annual runoff change and its relationship with water and soil conservation practices and climate change in the middle Yellow River basin显示文摘 | Changxing Shi Yuanyuan Zhou Xiaoli Fan Wenwei Shao | 2013 | Catena2013，，： | 1 |
| 9 | Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular carcinoma显示文摘Cabozantinib,mainly targeting cMet and vascular endothelial growth factor receptor 2,is the second-line treatment for patients with advanced hepatocellular carcinoma(HCC).However,the lower response rate and resistance limit its enduring clinical benefit.In this study,we found that cMet-low HCC cells showed primary resistance to cMet inhibitors,and the combination of cabozantinib and mammalian target of rapamycin(mTOR)inhibitor,rapamycin,exhibited a synergistic inhibitory effect on the in vitro cell proliferation and in vivo tumor growth of these cells.Mechanically,the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT,extracellular signal-regulated protein kinases,mTOR,and common downstream signal molecules of receptor tyrosine kinases;decreased cyclin D1 expression;and induced cell cycle arrest.Meanwhile,rapamycin enhanced the inhibitory effects of cabozantinib on the migration and tubule formation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant HCC cells under hypoxia condition.These effects were further validated in xenograft models.In conclusion,our findings uncover a potential combination therapy of cabozantinib and rapamycin to combat cabozantinib-resistant HCC. | Chao Gao Shenghao Wang Weiqing Shao Yu Zhang Lu Lu Huliang Jia Kejin Zhu Jinhong Chen Qiongzhu Dong Ming Lu Wenwei Zhu Lunxiu Qin | 2022 | Frontiers of Medicine2022，16，3： | 0 |
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