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| 1 | Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer显示文摘 | Jiang Kewei Lyu Liang Shen Zhanlong Zhang Jizhun Zhang Hui Dong Jianqiang Yan Yichao Liu Fangfang Wang Shan | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 2 | Enrichment-induced exercise to quantify the effect of different housing conditions: A tool to standardize enriched environment protocols显示文摘 | Hongyu Xie Yi Wu Jie Jia Gang Liu Qi Zhang Kewei Yu Zhenzhen Guo Li Shen Ruiping Hu | 2013 | Behavioural Brain Research2013，，： | 1 |
| 3 | An anatomical, histopathological, and molecular biological function study of the fascias posterior to the interperitoneal colon and its associated mesocolon: their relevance to colonic surgery显示文摘 | Zhidong Gao Yingjiang Ye Weiguang Zhang Danhua Shen Yanfeng Zhong Kewei Jiang Xiaodong Yang Mujun Yin Bin Liang Long Tian Shan Wang | 2013 | J. Anat2013，，： | 1 |
| 4 | MSH2 is required for cell proliferation,cell cycle control and cell invasiveness in colorectal cancer cells显示文摘We have investigated the role of MSH2,a mismatch repair gene in cell proliferation,cell cycle control and cell invasiveness in the SW480 human colorectal cancer cell line.RNAi-mediated inhibition of MSH2 expression was achieved using MSH2 shRNA lentiviral expression vectors.Effective knockdown of endogenous MSH2 expression was determined by real-time PCR analysis.The most efficient MSH2 knockdown vector was selected for subsequent studies using SW480 cells.Endogenous MSH2 mRNA levels decreased after lentiviral delivery of the MSH2-RNAi,indicating efficient silencing of MSH2 expression in SW480 cells.Cell proliferation,cell cycle progression and cell invasiveness were quantified by MTT assays,flow cytometry and transwell assays,respectively.RNAi-mediated inhibition of MSH2 expression in SW480 cells resulted in decreased cell proliferation,cell cycle arrest at the G0/G1 phase and decreased cell invasiveness.Taken together,these results provide evidence that MSH2 stimulates cell proliferation,promotes cell cycle progression and positively regulates cell invasiveness. | SHEN Kai YE YingJiang JIANG KeWei LIANG Bin YANG XiaoDong WANG Shan | 2012 | Chinese Science Bulletin2012，57，20： | 1 |
| 5 | Metabolic syndrome is an important factor for the evolution of prognosis of colorectal cancer: survival, recurrence, and liver metastasis显示文摘 | Zhanlong Shen Yingjiang Ye Liang Bin Mujun Yin Xiaodong Yang Kewei Jiang Shan Wang | 2010 | The American Journal of Surgery2010，，1： | 1 |
| 6 | Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing显示文摘Objective:The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitisassociated cancer(CAC)and to reveal a potential evolutionary trajectory from ulcerative colitis(UC)to CAC at the single-cell level.Methods:Fresh samples of tumor tissues and adjacent UC tissues from a CAC patient with pT3N1M0 stage cancer were examined by single-cell RNA sequencing(scRNA-seq).Data from The Cancer Genome Atlas(TCGA)and The Human Protein Atlas were used to confirm the different expression levels in normal and tumor tissues and to determine their relationships with patient prognosis.Results:Ultimately,4,777 single-cell transcriptomes(1,220 genes per cell)were examined,of which 2,250(47%)and 2,527(53%)originated from tumor and adjacent UC tissues,respectively.We defined the composition of cancer-associated stromal cells and identified six cell clusters,including myeloid,T and B cells,fibroblasts,endothelial and epithelial cells.Notable pathways and transcription factors involved in these cell clusters were analyzed and described.Moreover,the precise cellular composition and developmental trajectory from UC to UCassociated colon cancer were graphed,and it was predicted that CD74,CLCA1,and DPEP1 played a potential role in disease progression.Conclusions:scRNA-seq technology revealed intra-tumor cell heterogeneity in UC-associated colon cancer,and might provide a promising direction to identify novel potential therapeutic targets in the evolution from UC to CAC. | Quan Wang Zhu Wang Zhen Zhang Wei Zhang Mengmeng Zhang Zhanlong Shen Yingjiang Ye Kewei Jiang Shan Wang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 1 |
| 7 | Evaluation of the seventh AJCC TNM staging system for gastric cancer: a meta-analysis of cohort studies显示文摘 | Jizhun Zhang Yangbing Zhou Kewei Jiang Zhanlong Shen Yingjiang Ye Shan Wang | 2014 | Tumor Biology2014，，9： | 1 |
| 8 | Lateral earth pressure of granular backfills on retaining walls with expanded polystyrene geofoam inclusions under limited surcharge loading显示文摘Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,the failure mode and the earth pressure acting on the rigid retaining wall with EPS geofoam inclusions and granular backfills(henceforth referred to as EPS-wall),under limited surcharge loading are investigated through two-and three-dimensional model tests.The testing results show that different from the sliding of almost all the backfill in the EPS-wall under semi-infinite surcharge loading,only an approximately triangular backfill slides in the wall under limited surcharge loading.The distribution of the lateral earth pressure on the EPS-wall under limited surcharge loading is non-linear,and the distribution changes from the increase of the wall depth to the decrease with the increase of the limited surcharge loading.An approach based on the force equilibrium of a differential element is developed to predict the lateral earth pressure behind the EPS-wall subjected to limited surcharge loading,and its performance was fully validated by the three-dimensional model tests. | Kewei Fan Guangqing Yang Weilie Zou Zhong Han Yang Shen | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，4： | 0 |
| 9 | Phase Stability and Reactions of Subducting CaCO_(3)under Upper Mantle Conditions显示文摘CaCO_(3)is an important component of marine sediments and one of the major deep-carbon carriers at subduction zones.Some subducted CaCO_(3)can be dissolved in subduction fluids and recycled back to the surface via arc volcanoes degassing.At the same time,there still remain large amounts of CaCO_(3)and its reaction products,which could be further transported into Earth's deep interior.These internal processes link atmosphere,hydrosphere and biosphere with the deep solid Earth,modifying the environments of our planet.In this review,we summarize current understanding from high pressure-temperature experiments and field petrological observations on the physical and chemical properties of CaCO_(3).In particular,the phase stability and reactions of CaCO_(3)largely control the migration and reservation of oxidized carbon in subducting slabs.Finally,we present several critical but unsolved questions on CaCO_(3)subducting in the deep mantle. | GUI Weibin SHEN Kewei LIU Jin | 2023 | Acta Geologica Sinica(English Edition)2023，97，1： | 0 |
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