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| 1 | Advances in dye-sensitized solar cell显示文摘THE conversion of visible light to electricity using semiconductors as light absorbers has beenan important area of research for many years. In the 1970s, highly efficient photovoltaiccells based on silicon were developed (the light-to-electrical conversion efficiency≥25%),which provides energy to aircrafts. Then semiconductor liquid-junction photoelectrochemicalcell started to be investigated. Generally speaking, highly efficient liquid-junction photoelec-trochemical solar cells can be obtained by using semiconductors such as Si, GaAs and WSe.(band gap≈(1.3±0.3) eV). Conversion efficiencies over 15% have been acquired on solarcells consisting of single crystals of Si or GaAs. But the serious photocorrosion and high | Jing, BW Zhang, MH Shen, T | 1997 | Chinese Science Bulletin1997，42，23： | 6 |
| 2 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 3 | The inhibition of growth and angiogenesis in heterotransplanted esophageal carcinoma via intratumoral injection of arsenic trioxide显示文摘 | Shen ZY Shen J Chen MH | 2003 | Oncol Rep2003，10，6： | 1 |
| 4 | Early postoperative cognitive dysfunction is associated with higher cortisol levels in aged patients following hip fracture surgery显示文摘 | Ji MH Shen JC Gao R | 2013 | J Anesth2013，27，6： | 1 |
| 5 | Early postoperative cognitive dysfunction is associated with higher cortisol levels in aged patients following hip fracture surgery显示文摘 | Ji MH Shen JC Gao R | 2013 | J Anesth2013，27，6： | 1 |
| 6 | Prognostic significance of extranodal extension of regional lymph node metastasis in papillary thyroid cancer 显示文摘 | Wu MH Shen WT Gosnell J | 2015 | Head Neck2015，37，9： | 1 |
| 7 | Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese显示文摘 | Shen GP Pan QH Hong MH | 2011 | Int J Cancer2011，129，6： | 1 |
| 8 | Fractional laser as a tool to enhance the skin permeation of 5-aminolevulinic acid with minimal skin disruption:a comparison with conventional erbium:YAG laser显示文摘 | Lee WR Shen SC Pai MH | | 0，，02： | 1 |
| 9 | FDA drug approval summary:bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme显示文摘 | Cohen MH Shen YL Keegan P | 2009 | Oncologist2009，14，11： | 1 |
| 10 | Optimization of CDT-I andXYLl expression for balanced co-production of ethanol andxylitol form cellobiose and xylose by engineeredSaccharomyces cerevisiae显示文摘 | Zha J Li BZ Shen MH | 2013 | PLoS One2013，8，68： | 1 |
| 11 | Nitric oxide and calcium ions in apoptotic esphageal carcinoma ceils induced by arsenite显示文摘 | Shen ZY Shen WY Chen MH | 2002 | World J Gastroenterol2002，8，1： | 1 |
| 12 | FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme 显示文摘 | Cohen MH Shen YL Keegan P | 2009 | Oncologist2009，14，11： | 1 |
| 13 | Upregulated wxpressin of ezrin and invasive phenotype in malignantly transformed esophageal epi- thelial cells 显示文摘 | Shen ZY Xu LY Chen MH | 2003 | World J Gastroentero12003，9，6： | 1 |
| 14 | Effects of particle size reduction of insoluble fibres by micron technology on various caecal and faecal indices显示文摘 | Huang YL Shen F Lee MH | 2007 | Journal of the Science of Food and Agriculture2007，87，4： | 1 |
| 15 | Severe carbon dioxide embolism during laparoscopic kidney resection 显示文摘 | Shen JC Ji MH Yang C | 2011 | Acta Anaesthesiol Scand2011，55，4： | 1 |
| 16 | 查看详情显示文摘 | Chang C Z Zhang J Feng X Shen J Zhang Z C Guo MH LiK OuYB WeiP WangLL JiZQ FengY Ji S H Chen X Jia J F Dai X Fang Z Zhang S C He K Wang Y Y Lu L Ma X C Xue Q K | | 0，，： | 1 |
| 17 | Microbial synthesis ofpoly ( ε- lysine) and its various applications显示文摘 | SHIH IL SHEN MH VAN YT | 2006 | Bioresauree Technol2006，97，： | 1 |
| 18 | Application of response surface methodology to optimize production of poly-e-lysine by Streptomyces albulus IFO 14147 显示文摘 | Shih IL Shen MH | 2006 | Enzyme and Microbial Technology2006，39，1： | 1 |
| 19 | Recent Advances in Imaging of Dopaminergic Neurons for Evaluation of Neuropsychiatric Disor- ders显示文摘 | Shen LH Liao MH Tseng YC | 2012 | J Biomed Biotechnol2012，，： | 1 |
| 20 | Optimization of cell growth and poly (ε-lysine) production in batch and fed-batch cultures by Streptomyces albulus IFO 14147显示文摘 | Shih IL Shen MH | 2006 | Process Biochemisty2006，41，7： | 1 |
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