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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense C Ⅱ TA显示文摘 | Cai G Zhang J Liu L Shen Q | 2005 | 第二军医大学学报2005，26，8： | 7 |
| 3 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 4 | Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells显示文摘 | Li L Lu Q Shen Y | | 0，，： | 2 |
| 5 | SELECTIVE DIMERIZATION OF BUTANAL TO BUTYL BUTYRATE CATALYZED BY LANTHANOCENE/n-BuLi SYSTEMS显示文摘SELECTIVEDIMERIZATIONOFBUTANALTOBUTYLBUTYRATECATALYZEDBYLANTHANOCENE/n-BuLiSYSTEMS￥FanXU,LiLuZHANG,MingYAO,YuanChenDING,ZhiMi... | Xu, F Zhang, LL Yao, YM Ding, YC Bai, ZM Shen, Q | 1995 | Chinese Chemical Letters1995，6，7： | 2 |
| 6 | Geometric phase in spin precession and the adiabatic approximation 显示文摘 | Ni G J Chen S Q Shen Y L | 1995 | Phys Lett1995，197，： | 2 |
| 7 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 8 | 中国儿童呼吸道合胞病毒与急性下呼吸道感染负担:荟萃分析显示文摘呼吸道合胞病毒(RSV)与急性下呼吸道有关感染(ALRTI),在儿童中非常常见。RSV感染的疾病负担因国家而异,在中国尚不清楚。因此,这项荟萃分析旨在量化近年来中国儿童ALRTI相关RSV感染的阳性率。研究通过检索2015年1月1日至2018年12月31日发表在PubMed、Web of science、中国知网(CNKI)、万方和中国生物医学(CBM)数据库上与中国RSV相关文献。并按照严格的荟萃分析标准共纳入66799例ALRTI患者。使用R语言进行荟萃分析。 | Xie Z Qin Q Shen K 宋晶晶(编译) | 2021 | 中华医学杂志2021，101，36： | 2 |
| 9 | Atom transfer radical polymerization of methyl methacrylate by silica gel supported copper bromide/multidentate amine 显示文摘 | Shen Y Q Zhu S P Zeng F Q | 2000 | Macromolecules2000，33，15： | 1 |
| 10 | Design efficient support vector machine for fast classification显示文摘 | Zhang Y Q Shen D G | 2005 | Pattern Recognition2005，38，1： | 1 |
| 11 | Neutral Pd(II) and Ni (II) aeetylide catalysts for the polymerization of methyl methaerylate 显示文摘 | SUN H M SHEN Q PENG X G | 2002 | Catalysis Letters2002，80，12： | 1 |
| 12 | Field studies on 32P movement and P leaching from flooded paddy soils in the region of Taihu lake, China显示文摘 | Xie X J Ran W Shen Q R | 2004 | Environmental Geochemistry and Health2004，26，： | 1 |
| 13 | Location Characteristics of Inner-city Neighborhoods and Employment Accessibility of Low-wage Workers显示文摘 | | 1998 | Environment and Planning B:Planning and Design1998，25，： | 1 |
| 14 | The amylose content in rice endosperm is related to the post tran- scriptional regulation of the waxy gene 显示文摘 | Wang Z Y Zheng F Q Shen G Z | 1995 | Plant J1995，7，： | 1 |
| 15 | Multicycle study on chemical-looping combustion of simulated coal gas with a CaSO4 oxygen carrier in a fluidized bed reactor显示文摘 | SONG Q XIAO R DENG Z ZHENG W SHEN L XIAO J | 2008 | Energy Fuels2008，22，6： | 1 |
| 16 | Interaction of polycyclie aromatic hydrocarbons and heavy metals on soil enzyme显示文摘 | SHEN G LU Y ZHOU Q | 2005 | Chemosphere2005，61，8： | 1 |
| 17 | Effect of Temperature on reduction of CaSO4 oxygen carrier in chemical- looping combustion of simulated coal gas in a fluidized bed reactor显示文摘 | SONG Q XIAO R DENG Z SHEN L XIAO J ZHANG M | 2008 | Ind Eng Chem Res2008，47，21： | 1 |
| 18 | Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2 显示文摘 | Li M Chen Q Shen YN | 2009 | Exp Dermatol2009，18，7： | 1 |
| 19 | Endothelial ceils stimulate self-renewal and expand neurogenesis of neural stem cells显示文摘 | SHEN Q GODERIE S K JIN L | 2004 | Science2004，304，5675： | 1 |
| 20 | Structure and promoter analysis of an ABAand stress-regulated barley gene HVA1 显示文摘 | Straub P F Shen Q Ho T D | 1994 | Plant Molecular Biology1994，26，： | 1 |
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