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| 1 | MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1显示文摘 | Li Yang Huang Qiming Shi Xuehui Jin Xiang Shen Li Xu Xiaolin Wei Wenbin | 2014 | Chinese Medical Journal2014，，8： | 9 |
| 2 | Modeling tree root diameter and biomass by ground-penetrating radar显示文摘Roots play a key role in ecosystem functioning as they transfer water and nutrients from soil to plants.Traditional methods for measuring roots are labor-intensive and destructive in nature,which limits quantitative and repeatable assessments in longterm research.Ground-penetrating radar(GPR) provides a non-destructive method to measure plant roots.Based on the superiority of GPR with 2 GHz frequency,we developed a new,practical method to estimate root biomass.First,average root matter density was measured by collecting a small number of root samples.Second,under controlled,experimental conditions in a sandy area,a root diameter estimation model base on GPR was developed from which root diameter was estimated.Third,root volume was calculated using the estimated root diameter and assuming the shape of roots to be cylindrical.Finally,root biomass was estimated by averaging root matter density and root volume.Results of this study suggest the following:(1) the density of coarse roots with diameters greater than 0.5 cm is relatively uniform;(2) a new wave shape parameter,ΔT,extracted from profile data of 2 GHz frequency antenna is independent of root depth,thus enabling the construction of a root diameter estimation model with high accuracy;and(3) results of a field experiment demonstrated the GPR-based method to be feasible and effective in estimating biomass of coarse roots.These findings are helpful for improving GPR-based root diameter and biomass estimation models and suggest the potential of GPR data in studying root systems. | CUI XiHong CHEN Jin SHEN JinSong CAO Xin CHEN XueHong ZHU XiaoLin | 2011 | Science China Earth Sciences2011，54，5： | 8 |
| 3 | 1-MCP Regulates Ethanol Fermentation and GABA Shunt Pathway Involved in Kiwifruit Quality During Postharvest Storage显示文摘Kiwifruit(Actinidia deliciosa)‘Bruno’is prone to accumulate ethanol rapidly after respiratory climacteric during storage at ambient conditions without stresses,which causes quality deterioration of the fruit associated with alcohol off-flavor.For maintaining the postharvest quality of kiwifruit‘Bruno’,the effects of 1.0μL•L^−11-methylcyclopropene(1-MCP)treatment on regulating the ethanol fermentation andγ-aminobutyric acid(GABA)shunt pathway associated with control of alcohol off-flavor were investigated during storage at room temperature(24±1)°C for 27 days.The results showed that 1-MCP treatment significantly reduced the respiration rate,ethylene production,decay rate,ascorbic acid(AsA)loss,and delayed the decline in the firmness and titratable acidity(TA),and the increase in total soluble solid(TSS)in kiwifruit.Furthermore,1-MCP treatment effectively inhibited the increases in contents of acetaldehyde,ethanol,and GABA along with the suppressed activities of key enzymes involved in ethanol fermentation and GABA shunt pathway,such as pyruvate decarboxylase(PDC),alcohol dehydrogenase(ADH),glutamate decarboxylase(GAD),and GABA-transaminase(GABA-T)in kiwifruit during storage.In conclusion,1-MCP treatment efficiently regulated the ethanol fermentation and GABA shunt pathway by delaying the ripening process to avoid the alcohol off-flavor development,thereby contributed to maintaining the quality of the kiwifruit. | Maratab Ali Muhammad Ammar Raza Shenge Li Lichao Zhou Chen Huan Shen Shuling Xiaolin Zheng | 2021 | Horticultural Plant Journal2021，7，1： | 7 |
| 4 | Growth of covellite crystal onto azurite surface during sulfurization and its response to flotation behavior显示文摘In this work,the growth of copper sulfide crystal onto azurite surfaces during sulfurization and its response to flotation are investigated.Filed emission scanning electron microscopy-energy dispersive X-ray spectroscopy(FESEM) and X-ray diffraction(XRD) studies confirmed that the sulfurization of azurite is not limited to the mineral surface,but rather penetrates into the bulk to form covellite crystal(synCuS),creating favorable conditions for the stable adsorption of xanthate and greatly promoting the azurite flotation.Additionally,as demonstrated by X-ray photoelectron spectroscopy(XPS) and time of flight secondary ion mass spectrometry(TOF-SIMS) analyses,a redox reaction occurred during this process,and Cu(Ⅱ) onto the mineral surface was reduced to Cu(Ⅰ).Correspondingly,reduced S^(2-) was oxidized to(S_(2))^(2-),(S_n)^(-2),and even to deeper oxidation state S~0,(S_(x)O_(y))^(n-) and SO_(4)^(2-).Excess sodium sulfide strengthens copper sulfide to form onto the azurite surface,and provides enough raw material for crystal copper sulfide to grow,resulting in the formation of 'flake-like' covellite with a better crystallinity.However,the floatability of azurite decreased dramatically under this condition,because the generated massive colloidal copper sulfide in flotation pulp deteriorates the flotation environment,resulting in a decreased effective adsorption of collector onto azurite surfaces. | Jinpeng Cai Peilun Shen Dianwen Liu Xiaolin Zhang Jianjun Fang Chao Su Xingcai Yu Jiangli Li Han Wang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 4 |
| 5 | Fundamental CRISPR-Cas9 tools and current applications in microbial systems显示文摘Derived from the bacterial adaptive immune system,CRISPR technology has revolutionized conventional genetic engineering methods and unprecedentedly facilitated strain engineering.In this review,we outline the fundamental CRISPR tools that have been employed for strain optimization.These tools include CRISPR editing,CRISPR interference,CRISPR activation and protein imaging.To further characterize the CRISPR technology,we present current applications of these tools in microbial systems,including model-and non-model industrial microorganisms.Specially,we point out the major challenges of the CRISPR tools when utilized for multiplex genome editing and sophisticated expression regulation.To address these challenges,we came up with strategies that place emphasis on the amelioration of DNA repair efficiency through CRISPR-Cas9-assisted recombineering.Lastly,multiple promising research directions were proposed,mainly focusing on CRISPR-based construction of microbial ecosystems toward high production of desired chemicals. | Pingfang Tian Jia Wang Xiaolin Shen Justin Forrest Rey Qipeng Yuan Yajun Yan | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 4 |
| 6 | Observer-based adaptive sliding mode backstepping output-feedback DSC for spin-stabilized canard-controlled projectiles显示文摘This article presents a complete nonlinear controller design for a class of spin-stabilized canard-controlled projectiles.Uniformly ultimate boundedness and tracking are achieved,exploiting a heavily coupled,bounded uncertain and highly nonlinear model of longitudinal and lateral dynamics.In order to estimate unmeasurable states,an observer is proposed for an augmented multiple-input-multiple-output(MIMO) nonlinear system with an adaptive sliding mode term against the disturbances.Under the frame of a backstepping design,an adaptive sliding mode output-feedback dynamic surface control(DSC) approach is derived recursively by virtue of the estimated states.The DSC technique is adopted to overcome the problem of ‘‘explosion of complexity' and relieve the stress of the guidance loop.It is proven that all signals of the MIMO closed-loop system,including the observer and controller,are uniformly ultimately bounded,and the tracking errors converge to an arbitrarily small neighborhood of the origin.Simulation results for the observer and controller are provided to illustrate the feasibility and effectiveness of the proposed approach. | Yuanchuan SHEN Jianqiao YU Guanchen LUO Xiaolin AI Zhenyue JIA Fangzheng CHEN | 2017 | Chinese Journal of Aeronautics2017，30，3： | 4 |
| 7 | Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation显示文摘Fundamental processes such as ribosomal RNA synthesis and chromatin remodeling take place in the nucleolus,which is hyperactive in fast-proliferating cells.The sophisticated regulatory mechanism underlying the dynamic nucleolar structure and functions is yet to be fully explored.The present study uncovers the mutual functional dependency between a previously uncharacterized human long non-coding RNA,which we renamed LETN,and a key nucleolar protein,NPM1.Specifically,being upregulated in multiple types of cancer,LETN resides in the nucleolus via direct binding with NPM1.LETN plays a critical role in facilitating the formation of NPM1 pentamers,which are essential building blocks of the nucleolar granular component and control the nucleolar functions.Repression of LETN or NPM1 led to similar and profound changes of the nucleolar morphology and arrest of the nucleolar functions,which led to proliferation inhibition of human cancer cells and neural progenitor cells.Interestingly,this inter-dependency between LETN and NPM1 is associated with the evolutionarily new variations of NPM1 and the coincidental emergence of LETN in higher primates.We propose that this human-specific protein–lncRNA axis renders an additional yet critical layer of regulation with high physiological relevance in both cancerous and normal developmental processes that require hyperactive nucleoli. | Xianteng Wang Xiaolin Hu Wanlu Song Hui Xu Zhengtao Xiao Rongyao Huang Qingran Bai Fan Zhang Yongzhen Chen Yu Liu Jianhuo Fang Xin Li Qin Shen Haitao Zhao Xuerui Yang | 2021 | Cell Research2021，31，6： | 3 |
| 8 | Large specific surface area S-doped Fe-N-C electrocatalysts derived from Metal-Organic frameworks for oxygen reduction reaction显示文摘It is highly desired but challenging to develop platinum group metal-free electrocatalysts for oxygen reduction reaction(ORR),which can promote the commercialization of fuel cell technology.To achieve this target,we report a one-step doping method to prepare S-doped Fe-N-C catalysts using zeolite imidazole framework(ZIF-8)and iron(Ⅲ)thiocyanate(Fe(SCN)_(3))as precursor.Different from conventional doping approach,i.e.physical mixing,Fe(SCN)_(3) is in-situ added during ZIF-8 formation which would encapsulate Fe(SCN)_(3) molecules inside ZIF-8 to avoid structure destruction and create potential replacement of Zn ions by Fe ions to form uniform Fe-N_(4) complexes.As a result,the prepared S-doped Fe-N-C catalysts own large specific surface areas with a maximum value of 1326 m^(2) g^(-1) and a dual-scale porous structure that benefits mass transport.Significantly,the composition-optimized catalyst exhibits superior ORR activity in both 0.1 M HClO_(4) electrolyte and 0.1 M KOH electrolyte,in which the half-wave potential reaches 0.81 V and 0.92 V(vs.RHE),respectively.Remarkable stability is also attained,which loses 2 m V only after 10000 potential cycles in O_(2)-saturated 0.1 M HClO_(4) and remains almost constant in O_(2)-saturated 0.1 M KOH,surpassing commercial Pt/C catalyst in both acidic and alkaline medium. | Xiaohui Yan Xiaolin Li Cehuang Fu Chen Lin Huanming Hu Shuiyun Shen Guanghua Wei Junliang Zhang | 2020 | Progress in Natural Science:Materials International2020，30，6： | 3 |
| 9 | Computationally efficient direction finding using polynomial rooting with reduced-order and real-valued computations显示文摘The root multiple signal classification(root-MUSIC) algorithm is one of the most important techniques for direction of arrival(DOA) estimation. Using a uniform linear array(ULA) composed of M sensors, this method usually estimates L signal DOAs by finding roots that lie closest to the unit circle of a(2M-1)-order polynomial, where L < M. A novel efficient root-MUSIC-based method for direction estimation is presented, in which the order of polynomial is efficiently reduced to 2L. Compared with the unitary root-MUSIC(U-root-MUSIC) approach which involves real-valued computations only in the subspace decomposition stage, both tasks of subspace decomposition and polynomial rooting are implemented with real-valued computations in the new technique,which hence shows a significant efficiency advantage over most state-of-the-art techniques. Numerical simulations are conducted to verify the correctness and efficiency of the new estimator. | Fenggang Yan Yi Shen Ming Jin Xiaolin Qiao | 2016 | Journal of Systems Engineering and Electronics2016，27，4： | 3 |
| 10 | Prospect and key techniques of Global Energy Interconnection Zhangjiakou Innovation Demonstration Zone显示文摘In the Background of implementing innovation-driven development strategy and building Global Energy Interconnection, the necessity of building Global Energy Interconnection Zhangjiakou Innovation Demonstration Zone for stimulating economic growth, promoting social development and supporting 2022 Winter Olympics are discussed by analyzing the location advantages of Zhangjiakou and the characteristics of renewable energy in Zhangjiakou. Solutions are put forward in aspects of renewable energy integration in National Wind/Solar/Storage/Transmission Pilot Project, VSC-HVDC transmission of renewable energy and demonstration utilization of renewable energy in the Olympics zone, which could be a reference for problems of large-scale renewable energy in secure integration, outgoing transmission and flexible consumption. And replicable experience for building Global Energy Interconnection will be provided by conducting ±500 kV VSC-HVDC Power Grid Demonstration Project, Virtual Synchronous Generator Demonstration Project, Flexible Substation and AC/DC Power Distribution Network Demonstration Project, EV Battery Secondary Utilization Energy Storage Demonstration Project, Smart Grid Demonstration Project of Low Carbon Winter Olympics and other demonstration projects. | Bo Tian Xiaolin Mo Yu Shen Weimin Lei Pengliang Xu | 2018 | Global Energy Interconnection2018，1，2： | 3 |
| 11 | Task-Aware Flow Scheduling with Heterogeneous Utility Characteristics for Data Center Networks显示文摘With the continuous enrichment of cloud services, an increasing number of applications are being deployed in data centers. These emerging applications are often communication-intensive and data-parallel, and their performance is closely related to the underlying network. With their distributed nature, the applications consist of tasks that involve a collection of parallel flows. Traditional techniques to optimize flow-level metrics are agnostic to task-level requirements, leading to poor application-level performance. In this paper, we address the heterogeneous task-level requirements of applications and propose task-aware flow scheduling. First, we model tasks' sensitivity to their completion time by utilities. Second, on the basis of Nash bargaining theory, we establish a flow scheduling model with heterogeneous utility characteristics, and analyze it using Lagrange multiplier method and KKT condition. Third, we propose two utility-aware bandwidth allocation algorithms with different practical constraints. Finally, we present Tasch, a system that enables tasks to maintain high utilities and guarantees the fairness of utilities. To demonstrate the feasibility of our system, we conduct comprehensive evaluations with realworld traffic trace. Communication stages complete up to 1.4 faster on average, task utilities increase up to 2.26,and the fairness of tasks improves up to 8.66 using Tasch in comparison to per-flow mechanisms. | Fang Dong Xiaolin Guo Pengcheng Zhou Dian Shen | 2019 | Tsinghua Science and Technology2019，24，4： | 2 |
| 12 | Role of ammonium sulfate in sulfurization flotation of azurite:Inhibiting the formation of copper sulfide colloid and its mechanism显示文摘In this study,the role of(NH_(4))_(2)SO_(4)during the sulfurization of azurite and its response to flotation were investigated.The flotation results showed that adding(NH_(4))_(2)SO_(4)prior to sulfurization decreased the formation of colloid in flotation pulp,and the floatability of the suppressed azurite caused by excess sodium sulfide was restored.After adding(NH_(4))_(2)SO_(4)prior to sulfurization,the formation of Cu(NH_(3))_(n) ^(2+)intermediate products changed the path of the sulfurization reaction,which slowed the direct impact of HSon the azurite surface.The nucleation rate was reduced,and the growth of copper sulfide crystal was improved.Covellite(syn,CuS)with larger crystal grains was formed on the azurite surface,thereby enhancing the mechanical stability of copper sulfide products onto the mineral surface.Therefore,the generated copper sulfide colloid significantly reduced,ultimately promoting the effective adsorption of xanthate on the azurite surface. | Jinpeng Cai Chao Su Yinyu Ma Xingcai Yu Rong Peng Jiangli Li Xiaolin Zhang Jianjun Fang Peilun Shen Dianwen Liu | 2022 | International Journal of Mining Science and Technology2022，32，3： | 2 |
| 13 | Fusion hindrance in the neck evolution of symmetric nuclear reactions显示文摘Fusion hindrance in the radial degree of freedom for massive nuclear reactions is known for a long time. However the present work shows that the fusion hindrance also exists in the neck evolution. We calculate the potential at different distances and different neck parameters by the two-center liquid drop model and then check whether fusion hindrance exists in the neck evolution by examing the sign of slope of potential vs. the neck parameter. The area of fusion hindrance in the neck evolution is shown. | WANG XiaoLin SHEN CaiWan LI QingFeng LIU Ling | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 2 |
| 14 | Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer显示文摘 | Ruizhe Shen Shen Pan Shengjian Qi Xiaolin Lin Shidan Cheng | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 15 | Microbi- al biosynthesis of the anticoagulant precursor 4-hydroxy- coumarin 显示文摘 | Lin Yuheng Shen Xiaolin Yuan Qipeng | 2013 | Nature Communications2013，，4： | 1 |
| 16 | Development and applications of Baosteel sintering flue gas desulphuri- zation technology 显示文摘 | Shen Xiaolin Liu Daoqing Lin Yu | | Baosteel Technology0，，3： | 1 |
| 17 | Species and Functions of Rhizobia Growing on Trees and Colonization Mechanisms显示文摘The current research progress in China shows that the tree species of rhizobia that have been found are mainly trees of 11 genera in Papilionaceae,Elaeagnaceae and Mimosaceae,and the rhizobia are mainlyα-rhizobia,which come from multiple genera.Temperature,pH value,NaCl content and antibiotics all affect the growth of tree rhizobia;and different species of rhizobia have different stress resistance,which is related to their living environment.Rhizobium inoculation can promote plant height,biomass,root-to-shoot ratio,and root architecture of trees.We discussed and analyzed the development history and application status of rhizobia research,and prospected their future development directions.In the future,tree rhizobia will surely be used as a means of production to promote efficient agricultural production and sustainable agricultural systems. | Weixin CHEN Xiaolin SHEN Chaoyi YE Yihan SU Chengxiang XU | 2021 | Agricultural Biotechnology2021，10，5： | 1 |
| 18 | Analy- sis of a single-effect mechanical vapor compression desali- nation system using water injected twin screw compressors 显示文摘 | Shen Jiubing Xing Ziwen Wang Xiaolin | 2014 | Desalination2014，333，1： | 1 |
| 19 | Recent advances in microbial production of phenolic compounds显示文摘Phenolic compounds(PCs)are a group of compounds with various applications in nutraceutical,pharmaceutical and cosmetic industries.Their supply by plant extraction and chemical synthesis is often limited by low yield and high cost.Microbial production represents as a promising alternative for efficient and sustainable production of PCs.In this review,we summarize recent advances in this field,which include enzyme mining and engineering to construct artificial pathways,balance of enzyme expression to improve pathway efficiency,coculture engineering to alleviate metabolic burden and side-reactions,and the use of genetic circuits for dynamic regulation and high throughput screening.Finally,current challenges and future perspectives for efficient production of PCs are also discussed. | Xinxiao Sun Xianglai Li Xiaolin Shen Jia Wang Qipeng Yuan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 20 | The effects and mechanisms of high loading dose rosuvastatin therapy before percutaneous coronary intervention in patients with acute coronary syndrome显示文摘 | Jun Luo Jiang Li Xiangqian Shen Xinqun Hu Zhenfei Fang Xiaolin Lv Shenghua Zhou | 2012 | International Journal of Cardiology2012，，： | 1 |
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