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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Challenges of emergency logistics management 显示文摘 | SHEU J B | 2007 | Transportation Research Part E: Logistics and Transportation Review2007，43，6： | 1 |
| 3 | Cyto toxicity of rabbitmacrophage peptides MCP21 and MCP22 for mouse tumorcells显示文摘 | Sheu M J Balwin W W Bmnson K W | 1985 | Antimicr Agents Chemother1985，26，8： | 1 |
| 4 | Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models显示文摘 | Sheu MY Fowler AJ Kao J | 2002 | J Invest Dermatol2002，118，1： | 1 |
| 5 | Information Technology and Supply Chain Collaboration : Moderating Effects of Existing Relationships between Partners 显示文摘 | Chae B S Yen H J R Sheu C | 2005 | IEEE Transactions on Engineering Management2005，52，4： | 1 |
| 6 | An emergency logistics distribution approach for quick response to urgent relief demand in disasters显示文摘 | Sheu J B | 2007 | Transportation Research Part E2007，43，1： | 1 |
| 7 | Isolation and characterization of an immunomodulatory protein (APP) from the Jew's Ear mushroom Auricularia polytricha显示文摘 | SHEU F CHIENP J CHIEN A L | 2004 | Food Chemistry2004，87，4： | 1 |
| 8 | Kinetic studies and mathematical model for enzymatic roduction of fructooligosaccharides from sucrose显示文摘 | Duan K J Sheu D C Sheu D C | 1994 | Enzyme Microb Technol1994，16，4： | 1 |
| 9 | An integrated logistics operational model for green-supply chain management显示文摘 | Sheu J B Chou Y H Hu C C | 2005 | Transportation Research Part E: Logistics and Transportation Review2005，41，4： | 1 |
| 10 | Dynamic relie&demand management for emergency logistics operations under large-scale disasters 显示文摘 | Sheu J | 2010 | Transportation Research Part E: Logistics and Transportation Review2010，46，1： | 1 |
| 11 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 12 | Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma显示文摘 | Shih IEM Sheu J J Santillan A | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 13 | The scaleless wings mutant in Bombyx mori is associated with a lack of scale precursor cell differ- entiation followed by excessive apoptosis 显示文摘 | Zhou Q X Li Y N Sheu X J | 2006 | Dev Genes Evol2006，216，11： | 1 |
| 14 | Performance Evaluation of Wireless Sensor Network with Hybrid Channel Access Mechanism 显示文摘 | Saho P K Sheu J P Chang Y C | 2009 | Journal of Network and Computer Applieatians2009，32，4： | 1 |
| 15 | Dynamic relief-demand management for emergency logistics operations under large-scale disasters显示文摘 | SHEU J B | 2010 | Transportation Research Part E2010，46，1： | 1 |
| 16 | Satellite retrieval of tropical precip- itation using combined International Satellite Cloud Climatology Project DX and SSM/I data 显示文摘 | Sheu R S Curry J A Liu G | 1996 | Journal of Geophysical Re- search: Atmospheres( 1984-2012)1996，101，21： | 1 |
| 17 | Environmental-regulation pricing strategies for green supply chain management显示文摘 | Chen Y J Sheu J B | 2009 | Transportation Research Part E: Logistics and Transportation Review2009，45，5： | 1 |
| 18 | Determination of coptisine, berberine and palmatine in traditional Chinese medicinal preparations by capillary electrophoresis显示文摘 | LIU Yingmei SHEU S J | 1993 | J Chromatogr: A1993，639，2： | 1 |
| 19 | An emergency logistics distribution approach for quick response to urgent relief demand in disasters 显示文摘 | SHEU J B | 2007 | Transportation Research Part E: Logistics and Transportation Review2007，43，6： | 1 |
| 20 | c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment 显示文摘 | Clem R J Sheu TT Richter BW | 2001 | J Biol Chem2001，276，10： | 1 |
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