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| 1 | Adjunctive aripiprazole for antipsychotic-related hyperprolactinaemia in patients with first-episode schizophrenia:a metaanalysis显示文摘Background Hyperprolactinaemia is a common antipsychotic(AP)-induced adverse effect,particularly in female patients.Aims This meta-analysis examined the efficacy and safety of adjunctive aripiprazole in preventing AP-related hyperprolactinaemia in patients with first-episode schizophrenia.Methods PubMed,PsycINFO,EMBASE,Cochrane Library,WanFang and China Journal Net databases were searched to identify eligible randomised controlled trials(RCTs).Primary outcomes were the reductions of serum prolactin level and prolactin-related symptoms.Data were independently extracted by two reviewers and analysed using RevMan(V.5.3).Weighted/standardised mean differences(WMDs/SMDs)±95%Cis were reported.Results In the five RCTs(n=400),the adjunctive aripiprazole(n=197)and the control groups(n=203)with a mean of 11.2 weeks of treatment duration were compared.The aripiprazole group had a significantly lower endpoint serum prolactin level in all patients(five RCTs,n=385;WMD:-50.43 ng/mL(95%Cl:-75.05 to-25.81),p<0.00001;l2=99%),female patients(two RCTs,n=186;WMD:-22.58 ng/mL(95%Cl:-25.67 to-19.49),p<0.00001;l2=0%)and male patients(two RCTs,n=127;WMD:-68.80 ng/mL(95%Cl:-100.11 to-37.49),p<0.0001).In the sensitivity analysis for the endpoint serum prolactin level in all patients,the findings remained significant(p<0.00001;l2=96%).The aripiprazole group was s叩erior to the control group in improving negative symptoms as assessed by the Positive and Negative Syndrome Scale(three RCTs,n=213;SMD:-0.51(95%Cl:-0.79 to-0.24),p=0.0002;l2=0%).Adverse effects and discontinuation rates were similar between the two groups.Conclusions Adjunctive aripiprazole appears to be associated with reduced AP-induced hyperprolactinaemia and improved prolactin-related symptoms in first-episode schizophrenia.Further studies with large sample sizes are needed to confirm these findings. | Wei Zheng Dong-Bin Cai Xin-Hu Yang Wei Zheng Gabor S Ungvari Chee H Ng Zhan-Ming Shi Mei-Ling Hu Yu-Ping Ning Yu-Tao Xiang | 2019 | General Psychiatry2019，32，5： | 4 |
| 2 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 3 | Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia:a meta-analysis of randomised controlled trials显示文摘Background Hyperprolactinaemia is a common adverse effect of antipsychotics(APs). The results of PeonyGlycyrrhiza decoction(PGD) as a potentially useful adjunctive treatment for hyperprolactinaemia are inconsistent.Aim This meta-analysis of randomised controlled trials(RCTs) examined the efficacy and safety of adjunctive PGD therapy for AP-induced hyperprolactinaemia.Methods English(PubMed, Embase, Cochrane Library,PsycINFO) and Chinese(Chinese National Knowledge Infrastructure, Wanfang Data) databases were systematically searched up to 10 June 2018. The inclusion criteria were based on PIC0 S一/^rticipants: adult patients with schizophrenia; Aitervention: PGD plus APs; Cbmparison: APs plus placebo or AP monotherapy;(Xjtcomes: efficacy and safety; Study design: RCTs. The weighted mean difference(WMD) and risk ratio(RR) along with their 95% CIs were calculated using Review Manager(RevMan) V.5.3 software.Results Five RCTs(n=450) were included and analysed.Two RCTs(n=140) were double-blind and four RCTs(n=409) reported ‘random' assignment with specific description. The PGD group showed a significantly lower serum prolactin level at endpoint than the control group(n=380, WMD:-32.69 ng/mL(95% Cl-41.66 to 23.72),/X0.00001, ^=97%). Similarly, the superiority of PGD over the control groups was also found in the improvement of hyperprolactinaemia-related symptoms. No difference was found in the improvement of psychiatric symptoms assessed by the Positive and Negative Syndrome Scale(n=403,WMD:-0.62(95% Cl-2.38 to 1.15), p=0.49, ^=0%). There were similar rates of all-cause discontinuation(n=330, RR0.93(95% Ci 0.63 to 1.37),/t=0.71, ^=0%) and adverse drug reactions between the two groups. According to the Grading of Recommendations Assessment, Development and Evaluation approach, the level of evidence of primary and secondary outcomes ranged from ‘very low'(14.3%),‘low'(42.8%),‘moderate'(14.3%),to ‘high,(28.6%>.Conclusions Current evidence supports the adjunctive use of PGD to suppress elevated prolactin and improve prolactininduced symptoms without significant adverse events in adult patients with AP-induced hyperprolactinaemia. Highquality RCTs with longer duration are needed to confirm these findings.Trial registration number 42016037017. | Wei Zheng Dong-Bin Cai Hai-Yan Li Yu-Jie Wu Chee H Ng Gabor S Ungvari Shan-Shan Xie Zhan-Ming Shi Xiao-Min Zhu Yu-Ping Ning Yu-Tao Xiang | 2018 | General Psychiatry2018，31，4： | 3 |
| 4 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 5 | Deposition mechanism of pyrolytic carbons at temperature between 800- 1200℃显示文摘 | LI H J YANG Z | 1997 | Carbon1997，35，12： | 1 |
| 6 | Prediction model of secondary substances in anthocyanins synthesis of purple corn显示文摘 | ZHU M SHI Z S LI F H | 2010 | Agricultural Science&Tech-nology2010，11，15： | 1 |
| 7 | Convergence and mean square stability of suboptimal estimator for systems with measurement packet dropping显示文摘 | ZHANG H S SONG X M SHI L | 2012 | IEEE Transactions on Automatic Control2012，57，5： | 1 |
| 8 | Effect of a free-range rais- ing system on growth performance, carcass yield, and meat quali- ty of slow-growing chicken显示文摘 | Wang K H Shi S R Dou T C | 2009 | Poult Sci2009，88，10： | 1 |
| 9 | Optimal sizing of grid connected micro-grid using partide swarm optimization considering interruptible loads 显示文摘 | HASSANZADEHFARD H MOGHADDAS-TAFRE- SHI S M HAKIMI S M | 2011 | Electrimacs2011，4，3： | 1 |
| 10 | Synthesis and anti- microbial activities of Schiff bases derived from 5-chlo- ro-salicylaldehyde 显示文摘 | Shi L Ge H M Tan S H | 2007 | European Journal of Medicinal Chemistry2007，42，4： | 1 |
| 11 | Impacts of reactive nitrogen on climate change in China显示文摘 | Shi Y L Cui S H Ju X T | 2015 | Scientific reports2015，5，： | 1 |
| 12 | Massive pulmonary embolism: treatment with the rotarex thrombectomy system 显示文摘 | LIU S SHI H B GU J R | 2011 | Cardiovasc Intervent Radiol2011，34，1： | 1 |
| 13 | Immuno protection against influenza virus H9N2 by the oral administration of recombinant Lactobacillus planta- rumNC8 expressing hemagglutinin in BALB/c mice 显示文摘 | SHI S H YANG W T YANG G L | 2014 | Virology2014，，： | 1 |
| 14 | Acaricidal activities of extracts of Stellera chamaejasme against Tetranychus viennensis (Acari: Tetraanychidae) 显示文摘 | Shi G L Liu S Q Cao H | 2004 | JOURNAL OF ECONOMIC ENTOMOLOGY2004，97，6： | 1 |
| 15 | Anisotropic biquadratic finite with superclose results 显示文摘 | SHI D Y MAO S P LIANG H | 2006 | J Sys Sci & Complexity2006，19，4： | 1 |
| 16 | Overexpression of a plasma membrane Na^+/H^+ anti porter gene improves salt tolerance in arabidopsis thaliana显示文摘 | SHI H LEE B H WU S J | 2003 | Nat Biotechnol2003，21，1： | 1 |
| 17 | Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins显示文摘 | Shi S T Polyak S J Tu H | 2002 | Virology2002，292，： | 1 |
| 18 | An application of relative difference quotient algorithm to topology optimization of truss structures with discrete variables显示文摘 | Chai S Shi L S Sun H C | 1999 | Struc Optim1999，18，： | 1 |
| 19 | Soil water distribution, uniformity and water use efficiency under alternate furry irrigation in arid areas显示文摘 | Zhang S Z Shi P Pan Y H | 2002 | Irrigation Science2002，19，： | 1 |
| 20 | Comparative study on the bioleaching of zinc sulphidos 显示文摘 | SHI S Y FANG Z H NI J R | 2006 | Process Biochemistry2006，41，： | 1 |
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