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| 1 | High level production of human proapo A-I by fed-batch culture of recombinant Esche-richia coli显示文摘 | Ohta K Shibui T Morimoto Y | 1993 | J Ferment Bioeng1993，75，2： | 1 |
| 2 | Primary CNS germ cell tumors in Japan and the United States: an analysis of 4 tumor registries 显示文摘 | McCarthy BJ Shibui S Kayama T | 2012 | Neuro Oncol2012，14，： | 1 |
| 3 | In vitro selection of a peptide inhibitor of human IL-6 using mRNA display显示文摘 | Kobayashi T Kakui M Shibui T | 2011 | Mo- lecular bioteehnology2011，48，2： | 1 |
| 4 | A novel method for development of malaria vaccines using full-length cDNA libraries显示文摘 | Shibui A Shiibashi T Nogami S | 2005 | Vaccine2005，23，34： | 1 |
| 5 | Primary CNS germ cell tumors in Japan and the United States: an anal- ysis of 4 tumor registries 显示文摘 | McCarthy B J Shibui S Kayama T | 2012 | Neuro Oncol2012，14，9： | 1 |
| 6 | A novel method for development of malaria vaccines using full-length eDNA libraries显示文摘 | Shibui A Shiibashi T Nogami S | 2005 | Vaccine2005，23，34： | 1 |
| 7 | Primary CNS germ cell tumors in Japan and the United States:an analysis of 4 tumor registries显示文摘 | Mc Carthy BJ Shibui S Kayama T | 2012 | Neuro Oncol2012，14，9： | 1 |
| 8 | Changes in expression of imprinted genes following treatment of human cancer cell lines with non-mutagenic or mutagenic carcinogens显示文摘 | SHIBUI T HIGO Y TSUTSUI T W | 2008 | Int J Oncol2008，33，2： | 1 |
| 9 | Proadrenomedullin N -- terminal 20 peptide (PAMP) reduces inward currents and Ca^2+ rises induced by nicotine bovine adrenal medullarycells 显示文摘 | Nagatomo T Shibuy AI Kabashma N | 1996 | Life Sci1996，59，20： | 1 |
| 10 | Effect of long-term nitrate treatment on cardiac events in patients with vasospastic angina 显示文摘 | Kosugi M Nakagomi A Shibui T | 2011 | Circ J2011，75，9： | 1 |
| 11 | Primary CNS germ cell tumors in Japan and the United States: an analysis of 4 tumor registries显示文摘 | McCarthy BJ Shibui S Kayama T | 2012 | Neuro Oncol2012，14，： | 1 |
| 12 | Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)显示文摘Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of prognosis.Standard therapy consists of resection with concomitant chemoradiotherapy.Resistance to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT activity.This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + PCZ.The primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR C000000108.Results: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in Japan.The median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,respectively.The median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,respectively.Grade 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse events.Conclusions: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM. | Shibui S Narita Y Mizusawa J Beppu T Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama T Kuratsu J Nakamura H Kochi M Minamida Y Yamaki T Kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T Yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita Y Nakazato Y Sato A Fukuda H Nomura K | 2013 | 中国神经肿瘤杂志2013，11，1： | 0 |
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