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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Fabrication and electrical properties of Bi4Ti3O12 ceramics by spark plasma sintering显示文摘 | TAKAHASHI J KAWANO S SHIMADA S | 1999 | Jpn J Appl Phys1999，38，： | 2 |
| 3 | Stromal invasion of the cervix can be excluded from the criteria using adjuvant radiotherapy following radical surgery for patients with cervical cancer显示文摘 | Shimada M Kigawa J Takahashi M er al | 2004 | Gynecol Oncol2004，93，3： | 1 |
| 4 | Ovarian endometrioid adenocarcinoma arising from endometriosis in a young woman显示文摘 | Tagashira Y Shimada M Kigawa J | 2003 | Gynecol Oncol2003，91，3： | 1 |
| 5 | Ovarian metastasis in carcinoma of the uterine cervix显示文摘 | Shimada M Kigawa J Nishimura R | | 0，，02： | 1 |
| 6 | Kinetics of steam gasification of nascent char from rapid pyrolysis of a Victorian brown coal显示文摘 | Bayarsaikhan B Hayashi J I Shimada T | 2005 | Fuel2005，84，1213： | 1 |
| 7 | The effects of cavity size and incremental technique on micro-tensile bond strength of resin composite in Class 1 cavities 显示文摘 | He Z Shimada Y Tagami J | 2007 | Dent Mater2007，23，5： | 1 |
| 8 | Detection of GAD-reactive CD4^+ cells in so-called 'type 1B' diabetes显示文摘 | Shimada A Kodama K Morimoto J | 2003 | Ann N Y Acad Sci2003，1005，5： | 1 |
| 9 | The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity and prolactin release显示文摘 | Aihara K Shimada J Miwa T | 2004 | Brain Research2004，1003，： | 1 |
| 10 | Long-term administration of eeraprost sodium for pulmonary arterial hypertension associated with congenital heart disease 显示文摘 | Oyamada J Toyono M Shimada S | 2009 | Inter Med2009，48，17： | 1 |
| 11 | Nedaplatin ra cisplatin derivative in cancer chemotherapy显示文摘 | Shimada M Itamochi H Kigawa J | 2013 | Cancer Manag Res2013，5，： | 1 |
| 12 | Treatment strategy for small hepatocellular carcinoma:comparison of long-term results after percutaneous ethanol injection therapy and surgical resection显示文摘 | Yamamoto J Okada S Shimada K | 2001 | Hepatology2001，34，4： | 1 |
| 13 | Silent and Clinically Overt Stroke in Older Japanese with White-coat and Sustained Hypertension显示文摘 | Kario K Shimada K Schwartz J E | 2001 | J Am Coll Cardiol2001，38，1： | 1 |
| 14 | Treatment for Pinch-off Syndrome Using a Video-assisted Thoracoscopic Surgery;Report of a Case显示文摘 | Shimada J Yanada M Nishimura M | 2006 | Kyobu Geka2006，59，6： | 1 |
| 15 | Three-dimensional soil resistivity inversion using patching method显示文摘 | ZHOU Qiyou SHIMADA J SAT() A | 1999 | Jounal of Social Engineering and Geological of Japan1999，39，6： | 1 |
| 16 | Anterior transhepatic approcch for isolated resection caudate lobe of the liver显示文摘 | Yamamoto J kosuge T Shimada K | 1999 | World J Surg1999，23，1： | 1 |
| 17 | Comparative effects of chelating agents on pulmonary toxicity of systemic nickel in mice 显示文摘 | XIE J FUNAKOSHI T SHIMADA H | 1996 | J Appl Toxicol1996，16，4： | 1 |
| 18 | The prognostic relevance of fascin expression in human gastric carcinoma显示文摘 | HASHIMOTO Y SHIMADA Y KAWAMURA J | 2004 | Oncology2004，67，34： | 1 |
| 19 | The porgnostic relevnace of fascin expression in human gastric caecrinoma显示文摘 | Hashimoto Y Shimada Y Kawmaura J | 2004 | Oncology2004，67，34： | 1 |
| 20 | Sulfhydryl Group/Dsiulfide Bond Interchange Reactions during Heat-Induced Gelation of whey Protein Isolate显示文摘 | Shimada K Cheftel J C | 1989 | J Agric Food Chem1989，37，： | 1 |
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