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| 1 | Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease显示文摘Parkinson’s disease(PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the elderly.The current treatment has been demonstrated to relieve symptoms,and the discovery of new small-molecule compounds has been regarded as a promising strategy.Of note,the homeostasis of the autolysosome pathway(ALP)is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of PD.Thus,pharmacological targeting autophagy with small-molecule compounds has been drawn a rising attention so far.In this review,we focus on summarizing several autophagy-associated targets,such as AMPK,m TORC1,ULK1,IMPase,LRRK2,beclin-1,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future. | Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 9 |
| 2 | History and perspectives of induction technology for agarwood production from cultivated Aquilaria in Asia: a review显示文摘Agarwood, the resinous product of Aquilaria spp.(Thymelaeaceae), is highly valued for medicinal and fragrant purposes. Unsustainable forest harvesting contributes to the declining population in the wild, threatening their existence. As a protection effort, cultivation occurred in range countries, mainly in Asia, effectively establishing mass plantations. The success of domesticating Aquilaria relies heavily on technological advancement in agarwood induction, without which the entire thriving industry will collapse. In this paper, we describe efforts since 1929 and current progress and variation in induction as practiced in Asia. The methods include traditional practices and artificial induction via inoculum and chemical inducer, experimented and patented or otherwise. Artificial induction methods are being developed to intensify agarwood production in terms of yield and quality. While traditional methods are commonly applied by rural planters, artificial methods with the use of specific agents/chemicals are seen as more appealing for inducing agarwood, and have a higher demand from entrepreneurs and plantation owners.Several issues related to induction technology faced by stakeholders in agarwood cultivation are presented, such as safety levels, cost, yields, and quality. We conclude by highlighting remaining challenges in induction methods and their associated technologies. | Putra Desa Azren Shiou Yih Lee Diana Emang Rozi Mohamed | 2019 | Journal of Forestry Research2019，30，1： | 4 |
| 3 | Regulated cell death(RCD)in cancer:key pathways and targeted therapies显示文摘Regulated cell death(RCD),also well-known as programmed cell death(PCD),refers to the form of cell death that can be regulated by a variety of biomacromolecules,which is distinctive from accidental cell death(ACD).Accumulating evidence has revealed that RCD subroutines are the key features of tumorigenesis,which may ultimately lead to the establishment of different potential therapeutic strategies.Hitherto,targeting the subroutines of RCD with pharmacological small-molecule compounds has been emerging as a promising therapeutic avenue,which has rapidly progressed in many types of human cancers.Thus,in this review,we focus on summarizing not only the key apoptotic and autophagy-dependent cell death signaling pathways,but the crucial pathways of other RCD subroutines,including necroptosis,pyroptosis,ferroptosis,parthanatos,entosis,NETosis and lysosomedependent cell death(LCD)in cancer.Moreover,we further discuss the current situation of several small-molecule compounds targeting the different RCD subroutines to improve cancer treatment,such as single-target,dual or multiple-target small-molecule compounds,drug combinations,and some new emerging therapeutic strategies that would together shed new light on future directions to attack cancer cell vulnerabilities with small-molecule drugs targeting RCD for therapeutic purposes. | Fu Peng Minru Liao Rui Qin Shiou Zhu Cheng Peng Leilei Fu Yi Chen Bo Han | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 4 |
| 4 | Autophagy and beyond:Unraveling the complexity of UNC-51-like kinase 1(ULK1)from biological functions to therapeutic implications显示文摘UNC-51-like kinase 1(ULK1),as a serine/threonine kinase,is an autophagic initiator in mammals and a homologous protein of autophagy related protein(Atg)1 in yeast and of UNC-51 in Caenorhabditis elegans.ULK1 is well-known for autophagy activation,which is evolutionarily conserved in protein transport and indispensable to maintain cell homeostasis.As the direct target of energy and nutrition-sensing kinase,ULK1 may contribute to the distribution and utilization of cellular resources in response to metabolism and is closely associated with multiple pathophysiological processes.Moreover,ULK1 has been widely reported to play a crucial role in human diseases,including cancer,neurodegenerative diseases,cardiovascular disease,and infections,and subsequently targeted small-molecule inhibitors or activators are also demonstrated.Interestingly,the non-autophagy function of ULK1 has been emerging,indicating that non-autophagy-relevant ULK1 signaling network is also linked with diseases under some specific contexts.Therefore,in this review,we summarized the structure and functions of ULK1 as an autophagic initiator,with a focus on some new approaches,and further elucidated the key roles of ULK1 in autophagy and non-autophagy.Additionally,we also discussed the relationships between ULK1 and human diseases,as well as illustrated a rapid progress for better understanding of the discovery of more candidate small-molecule drugs targeting ULK1,which will provide a clue on novel ULK1-targeted therapeutics in the future. | Ling Zou Minru Liao Yongqi Zhen Shiou Zhu Xiya Chen Jin Zhang Yue Hao Bo Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 5 | Downregulation of microRNA‐15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2‐induced Globo H expression显示文摘 | Chen‐Shiou Wu Chia‐Jui Yen Ruey‐Hwang Chou Jia‐Ni Chen Wei‐Chien Huang Chung‐Yi Wu Yung‐Luen Yu | 2014 | Int J Cancer2014，，7： | 3 |
| 6 | MicroRNA-18a Prevents Estrogen Receptor-α Expression, Promoting Proliferation of Hepatocellular Carcinoma Cells显示文摘 | Wan–Hsin Liu Shiou–Hwei Yeh Cho–Chun Lu Sung–Liang Yu Hsuan–Yu Chen Chien–Yu Lin Ding–Shinn Chen Pei–Jer Chen | 2009 | Gastroenterology2009，，2： | 2 |
| 7 | Estrogen Receptor α Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor 4α显示文摘 | Sheng–Han Wang Shiou–Hwei Yeh Wei–Hsiang Lin Kun–Huei Yeh Quan Yuan Ning–Shao Xia Ding–Shinn Chen Pei–Jer Chen | 2012 | Gastroenterology2012，，4： | 2 |
| 8 | Isolation of multiple isoforus of alpha- fibrinogenuse from the western diamondback rattlesnake Crotalus atrox: N- terminal sequence homologry with arcrod ,an antithrombotic agent from malayan viper显示文摘 | Hung C C Shiou S H | 1994 | Biochem Biophys Res Comman1994，，： | 1 |
| 9 | Effects of emulsification variables on fuel properties of two-and three-phase biodiesel emulsions显示文摘 | Lin Cherng - Yuan Lin Shiou - An | 2007 | Fuel2007，86，： | 1 |
| 10 | A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER‐Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation显示文摘 | Chiung‐Hui Fu Ruey‐Jen Lin John Yu Wen‐Wei Chang Guo‐Shiou Liao Wen‐Ying Chang Ling‐Ming Tseng Yi‐Fang Tsai Jyh‐Cherng Yu Alice L. Yu | 2014 | Stem Cells2014，，8： | 1 |
| 11 | A case study of highway traffic flow model - model validation and simulation 显示文摘 | Y Jiann - Shiou | 2002 | Control Applications2002，，12： | 1 |
| 12 | Effects of emulsification variables on fuel properties of two - and three - phase biodiesel emulsions显示文摘 | Cherng - Yuan Lin Shiou - An Lin | 2007 | Fuel2007，86，： | 1 |
| 13 | Properties of food gra de(edible) surfactants affecting subsurface remediation of chlorinated solvents 显示文摘 | Bor Jier Shiou Pavid A Sabatini Jeffrey H Harwell | 1995 | Envrionmental Science & Technology1995，29，12： | 1 |
| 14 | Ultra-precision surface finish of the hardened stainless mold steel using vibration-assisted ball polishing process显示文摘 | SHIOU Fang-jung CIOU Hong-siang | | 0，，7： | 1 |
| 15 | Elevated p53 promotes the processing of miR‐18a to decrease estrogen receptor‐α in female hepatocellular carcinoma显示文摘 | Chiao‐Ling Li Kun‐Huei Yeh Wan‐Hsin Liu Chi‐Ling Chen Ding‐Shinn Chen Pei‐Jer Chen Shiou‐Hwei Yeh | 2015 | Cancer2015，，4： | 1 |
| 16 | Thermal Evolution in Synthesized ZnO Varistors by Urea Process显示文摘 | Bi Shiou Tsai Y J | 1998 | Journal of Material Science Letters1998，7，7： | 1 |
| 17 | Development of a novel scattered triangulation laser probe with six linear chaege-coupled devices(CCDs)显示文摘 | SHIOU F J LIU M X | 2009 | Optics & Lasers in Engineering2009，47，2： | 1 |
| 18 | The effects of post excimer laser annealing on (Ba, Sr)TiO3 thin films at low substrate temperatures 显示文摘 | Bi shiou chiou | 2003 | Jpn J Appl Phys2003，42，： | 1 |
| 19 | Design analysis and applications of a 3D laser ball bar for accuracy calibration of multiaxis machines显示文摘 | FAN K CH WANG H SHIOU F J | 2004 | Journal of Manufacturing Systems2004，23，3： | 1 |
| 20 | Calculation of the unit normal vector using the cross-curve moving mask method for probe radius compensation of a freeform surface meas- urement显示文摘 | Lee Rueytsung Shiou Fangjung | 2010 | Measurement2010，43，4： | 1 |
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