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| 1 | Value of fasting plasma glucose to screen gestational diabetes mellitus before the 24th gestational week in women with different pre-pregnancy body mass index显示文摘Background:Gestational diabetes mellitus(GDM)is usually diagnosed between 24th and 28th gestational week using the 75-g oral glucose tolerance test(OGTT).It is difficult to predict GDM before 24th gestational week because fast plasma glucose(FPG)decreases as the gestational age increases.It is controversial that if FPG≥5.1 mmol/L before 24th gestational week should be intervened or not.The aim of this study was to evaluate the value of FPG to screen GDM before 24th gestational week in women with different pre-pregnancy body mass index(BMI).Methods:This was a multi-region retrospective cohort study in China.Women who had a singleton live birth between June 20,2013 and November 30,2014,resided in Beijing,Guangzhou and Chengdu,and received prenatal care in 21 selected hospitals,were included in this study.Pre-pregnancy BMI,FPG before the 24th gestational week,and one-step GDM screening with 75 g-OGTT at the 24th to 28th gestational weeks were extracted from medical charts and analyzed.The pregnant women were classified into four groups based on pre-pregnancy BMI:Group A(underweight,BMI<18.5 kg/m^2),Group B(normal,BMI 18.5-23.9 kg/m^2),Group C(overweight,BMI 24.0-27.9 kg/m^2)and Group D(obesity,BMI≥28.0 kg/m^2).The trend of FPG before 24th week of gestation was described,and the sensitivity and specificity of using FPG before the 24th gestational week to diagnose GDM among different pre-pregnancy BMI groups were reported.Differences in the means between groups were evaluated using independent sample t-test and analysis of variance.Pearson Chi-square test was used for categorical variables.Results:The prevalence of GDM was 20.0%(6806/34,087)in the study population.FPG decreased gradually as the gestational age increased in all pre-pregnancy BMI groups until the 19th gestational week.FPG was higher in women with higher pre-pregnancy BMI.FPG before the 24th gestational week and pre-pregnancy BMI could be used to predict GDM.The incidence of GDM in women with FPG≥5.10 mmol/L in the 19th to 24th gestational weeks and pre-pregnancy overweight or obesity was significantly higher than that in women with FPG≥5.10 mmol/L and pre-pregnancy BMI<24.0 kg/m^2(78.5%[62/79]vs.52.9%[64/121],χ^2=13.425,P<0.001).Conclusions:FPG decreased gradually as the gestational age increased in all pre-pregnancy BMI groups until the 19th gestational week.Pre-pregnancy overweight or obesity was associated with an increased FPG value before the 24th gestational week.FPG≥5.10 mmol/L between 19 and 24 gestational weeks should be treated as GDM in women with pre-pregnancy overweight and obesity. | Yu-Mei Wei Xin-Yue Liu Chong Shou Xing-Hui Liu Wen-Ying Meng Zi-Lian Wang Yun-Feng Wang Yong-Qing Wang Zhen-Yu Cai Li-Xin Shang Ying Sun Hui-Xia Yang | 2019 | Chinese Medical Journal2019，，8： | 13 |
| 2 | Increased hepatic peroxisome proliferator-activated receptor coactivator-la expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers显示文摘 | MA Jing-mei ZENG Chan-juan ZHANG Li SHOU Chong YANG Hui-xia | 2012 | Chinese Medical Journal2012，，7： | 6 |
| 3 | Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2:Current Evidence and Perspectives显示文摘With the widespread transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the medical community has organized efforts to determine a series of clinical questions about the virus.Critical questions have also arisen in the field of maternal-fetal medicine and have received increasing attention,as physiological and immunologic changes in pregnancy might potentially increase the susceptibility to SARS-CoV-2 infection and complications of the virus.1 Many early reports indicated that pregnant women with SARS-CoV-2 infection were not prone to experiencing severe disease. | Chong Shou Chen Wang Huixia Yang | 2023 | Maternal-Fetal Medicine2023，5，2： | 1 |
| 4 | TEUPONXN: A NEO-CLERODANE DITERPENE FROM TEUCRIUM JAPONICUM显示文摘A nco—clcrodane diterpcne, teuponin, was isolated from the aerial parts of Teucrium japonicum. Its structure was established as (12S)—19—nor—neo—clcroda— 15a—hydroxy—4,13-diene— 16,15;18,6β;20,12-triolide by spcctroscopic means. The absolute configuration was determined by X—ray diffraction analysis and CD spectrum. | Zhi Da MIN~1~*, Ning XIE~1, Shou Xun ZHAO~1, Chong Shu WANG~2, and Qi Tai ZHENG~2 1.Department of Phytochemistry, China Pharmaceutical University, Nanjing, 210009 2.Institute of Materia Medica, Chinese Academy of Medicinal Sciences, Beijing, 100050 | 1991 | Chinese Chemical Letters1991，2，5： | 0 |
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