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| 1 | Function and regulation of cholecystokinin-octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules显示文摘AIM To study the role of cholecystokinin octapeptide ( CCK-8), β-endorphin ( β-EP), and gastrin in an anorexic infantile rat model and no subsequent regulation of nose peptides by the Yunpi complex prescription ErBao Granule.METHODS We fed infantile rats with special prepared forage. A liquid extract of ErBao Granule was administered to the rats daily for 3weeks, CCK-8, β-EP, and gastrin concentrations in hypothalamus, gastric antrum, and plasma of the rats were measured by radioimmunoassay,and were compared with controls.RESULTS Treatment of rats with ErBao Granule inhibited CCK-8 secretion and increased β-EP and gastrin secretion. CCK-8 concentration in hypothalamus and plasma of model control group increased significantly and correlated negatively with food intake of models.respectively. β-EP concentration in gastric antrum and plasma of model control group decreased significantly and showed a positive correlation with food intake of models,respectively. Hypothalamus concentration of β-EP was similar in models and controls. Gastrin concentration in gastric antrum of models was lower than in the blank control group, and correlated positively to food intake of models.Finally, CCK-8 concentrations in plasma of rats showed a positive correlation with plasma β-EP(r- 0.68, P<0.05).CONCLUSION The increased plasma and hypothalamus concentration of CCK-8,decreased gastric antrum and plasma level of β-EP. and decreased gastric antrum concentration of gastrin are associated significantly with the anorexia of infantile anorexic rat models produced by special forage. ErBao Granule can reverse these changes, which may be the major mechanisms of ErBao Granule simulating feeding. | Yong Ping Du1 Yue Ping Zhang2 Shou Chuan Wang3 Jian Shi1 Shao Hua Wu1,1.Department of Traditional Chinese Medicine. Xijing Hospital, theFourth Military Medical University. Xi an 7101132, Shaanxi Province,China 2.Department of Pediatrics. Xijing Hospital, the Fourth Military MedicalUniversity. Xi’an 710032. Shaanxi Province. China 3.Department of Pediatrics. Nanjing University of Traditional ChineseMedicine, Nanjing71011?l, Jiangsu Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 14 |
| 2 | Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis显示文摘 | Shou Y Li L Prabhakaran K | 2004 | Biochem J2004，379，3： | 1 |
| 3 | Influence of anti-bi- otic therapy on mortality of critical illness caused or compli- cated by infection 显示文摘 | BARIE P S HYDO L J SHOU J | 2005 | Surg Infect2005，6，1： | 1 |
| 4 | Preparation and evaluation of non-bonded hyperbranched polymer-coated columns for capillary electrophoresis显示文摘 | Shou C Q Zhou C L Zhao C B | 2004 | Talanta2004，63，： | 1 |
| 5 | Competition mech- anism between microstructure type and inclusion levelin determining VHCF behavior of bainite/martensite dual phase steels 显示文摘 | YU Y GU J L SHOU F L | 2011 | International Journal of Fatigue2011，33，： | 1 |
| 6 | Effective Permeabil- ity of Gas Diffusion Layer in Proton Exchange Membrane Fuel Cells 显示文摘 | Shou D H Tang Y H Ye L | 2013 | International Journal of Hydrogen Energy2013，38，10： | 1 |
| 7 | An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells 显示文摘 | Chen Q Shou P Zhang L | 2014 | Stem Ceils2014，32，： | 1 |
| 8 | Economics of femtocell service provision显示文摘 | DUAN L HUANG J SHOU B | 2013 | IEEE Trans Mobile Compu2013，12，11： | 1 |
| 9 | Competition mechanism between microstructure type and inclusion level in determining VHCF behavior of bainite/martensite dual phase steels 显示文摘 | Yu Y Gu J L Shou F L | 2011 | International Journal of Fatigue2011，33，3： | 1 |
| 10 | Elliptically polarized pump-probe spectroscopy and its application to observation of electron-spin relaxation in GaAs quantum wells显示文摘 | LAI T S LIU L N SHOU Q | 2004 | Applied Physics Letters2004，85，18： | 1 |
| 11 | OCDMA-WDM-PON-Solution Path to Next Generation Optical Access Network显示文摘 | Qian Y L Shou Z | 2008 | Dynamics of Continuous Discrete and Impulsive Systems Series B2008，4，15： | 1 |
| 12 | Laparoscope - assisted diagnosis and treatment of prepyloric web in children report of three cases 显示文摘 | Bing L Wei - Bing C Shou - Qing W Ye - Bo W | 2013 | J Pediatr Surg2013，48，16： | 1 |
| 13 | Microwave-assisted one step high-throughput synthesis of benzimidazoles显示文摘 | Shou Y L Yuko I Ethan Stewart | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 14 | Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis:involvement of muscarinic and NMDA receptors显示文摘 | Li L Shou Y Borowitz JL | 2001 | Toxicol Appl Pharmacol2001，177，： | 1 |
| 15 | Novel monoclonal antibodies to ESAT-6 and CFP-10 antigens for ELISA-based diagnosis of pleural tuberculosis显示文摘 | Feng T T Shou C M Shen L | 2011 | Int J Tuberc Lung Dis2011，15，6： | 1 |
| 16 | Development of microsatellite markers for blunt snout bream Megalobrama amblycephala using 5'-anchored PCR显示文摘 | Shou T Si L Wan C | | 0，，03： | 1 |
| 17 | Using high-resolution satellite image to evaluate nitrogen status of winter wheat in the north China plain 显示文摘 | Shou L N Jia L L Chen X P | 2007 | Journal of Plant Nutrition2007，30，10： | 1 |
| 18 | Importance of injection solution composition for LC-MS-MS methods显示文摘 | WENG N D CHEN Y L SHOU W JIANG X Y | 2001 | J Pharm Biomed Anal2001，26，3： | 1 |
| 19 | The human TBX5 gene mutation database显示文摘 | HEINRITZ W SHOU L MOSCHIK A | 2005 | Hum Mutat2005，26，： | 1 |
| 20 | Neuronal protein synuclein gam- ma predicts poor clinical outcome in breast cancer 显示文摘 | Guo J Shou C Meng L | 2007 | Int J Cancer2007，121，6： | 1 |
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