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您的检索式：作者名="SHUI Dongdong"
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| 1 | ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity显示文摘Glycosphingolipid (GSL) metabolism is involved in various physiological processes, including all major cell signaling pathways, and its dysregulation is linked to some diseases. The four-phosphate adaptor protein FAPP2-mediated glucosylceramide (GlcCer) transport for complex GSL synthesis has been studied extensively. However, the molecular machinery of FAPP2 as a GlcCer-transferring protein remains poorly defined. Here, we identify a Golgi-resident protein, acyl-coenzyme A binding domain containing 3 (ACBD3), as an interacting partner of FAPP2. We find that ACBD3 knockdown leads to dramatic Golgi fragmentation, which subsequently causes FAPP2 dispersal throughout the cytoplasm and a decreased localization at trans-Golgi network. The further quantitative Upidomic analysis indicates that ACBD3 knockdown triggers abnormal sphingolipid metabolism. Interestingly, the expression of siRNA-resistant full-length ACBD3 can rescue these defects caused by ACBD3 knockdown. These data reveal critical roles for ACBD3 in maintaining the integrity of Golgi morphology and cellular sphingolipid homeostasis and establish the importance of the integrated Golgi complex for the transfer of GlcCer and complex GSL synthesis. | Jing Liao Yuxiang Guan Wei Chen Can Shi Dongdong Yao Fengsong Wang Sin Man Lam Guanghou Shui Xinwang Cao | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 2 | Uncertain optimal model and solving method to platform scheduling problem in battlefield显示文摘The platform scheduling problem in battlefield is one of the important problems in military operational research.It needs to minimize mission completing time and meanwhile maximize the mission completing accuracy with a limited number of platforms.Though the traditional certain models obtain some good results,uncertain model is still needed to be introduced since the battlefield environment is complex and unstable.An uncertain model is prposed for the platform scheduling problem.Related parameters in this model are set to be fuzzy or stochastic.Due to the inherent disadvantage of the solving methods for traditional models,a new method is proposed to solve the uncertain model.Finally,the practicability and availability of the proposed method are demonstrated with a case of joint campaign. | Yu Sun Peiyang Yao Dongdong Shui Jieyong Zhang | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 2 |
| 3 | Sparse channel recovery with inter-carrier interference self-cancellation in OFDM显示文摘A new sparse channel estimation method of orthogonal frequency division multiplexing(OFDM) system based on intercarrier interference(ICI) self-cancellation is investigated. Firstly,based on the characteristic that the ICI generated by a subcarrier to the two adjacent subcarriers is approximately equal, a data pair with opposite sign and equal magnitude is modulated onto two adjacent subcarriers as pilot pair to eliminate the effect of ICI on pilots. Secondly, a new OFDM channel estimation model based on linear time-varying(LTV) model and compressed sensing(CS) is constructed, which obtains the mean of the gains of the multipath.Finally, a pilot pair optimization algorithm based on two layers loop is used to realize the minimization of the mutual coherence of the measurement matrix. For time-varying channel scenes with different numbers or delay of multipath and maximum Doppler frequency shift, the performances of several channel estimation methods are verified by simulation. The result shows that the new method has obvious advantage in both the performance of the channel estimation and the spectral efficiency. | HU Jiansheng SONG Zuxun GUO Shuxia ZHANG Qian SHUI Dongdong | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 2 |
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