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| 1 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 2 | Application of positron emission tomography/computed tomography in radiation treatment planning for head and neck cancers显示文摘18-fluorodeoxygluocose positron emission tomography/computed tomography(18FDG-PET/CT) provides significant information in multiple settings in the management of head and neck cancers(HNC). This article seeks to define the additional benefit of PET/CT as related to radiation treatment planning for squamous cell carcinomas(SCCs) of the head and neck through a review of relevant literature. By helping further define both primary and nodal volumes, radiation treatment planning can be improved using PET/CT. Special attention is paid to the independent benefit of PET/CT in targeting mucosal primaries as well as in detecting nodal metastases. The utility of PET/CT is also explored for treatment planning in the setting of SCC of unknown primary as PET/CT may help define a mucosal target volume by guiding biopsies for examination under anesthesia thus changing the treatment paradigm and limiting the extent of therapy. Implications of the use of PET/CT for proper target delineation in patients with artifact from dental procedures are discussed and the impact of dental artifact on CT-based PET attenuation correction is assessed. Finally, comment is made upon the role of PET/CT in the high-risk post-operative setting, particularly in the context of radiation dose escalation. Real case examples are used in these settings to elucidate the practical benefits of PET/CT as related to radiation treatment planning in HNCs. | Musaddiq J Awan Farzan Siddiqui David Schwartz Jiankui Yuan Mitchell Machtay Min Yao | 2015 | World Journal of Radiology2015，7，11： | 2 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Extraction of high-viscosty gums from oats显示文摘 | WOOD P J SIDDIQUI L R PATON 19 | 1978 | Cereal Chem1978，55，6： | 1 |
| 5 | Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of Pregnancy 显示文摘 | Laifer S A Stiller R J Siddiqui D S | 2001 | J Matem Fetal Med2001，10，2： | 1 |
| 6 | NUT midline carcinomamimicking tonsillitis in an eight-year-old girl 显示文摘 | Rutt A L Poulik J Siddiqui A H ef al | 2011 | Ann Otol RhinolLaryngol2011，120，8： | 1 |
| 7 | Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality显示文摘 | Osuehowski MF Weleh K Siddiqui J | 2006 | J ImmunoI2006，177，： | 1 |
| 8 | Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality显示文摘 | Osuchowski MF Welch K Siddiqui J | 2006 | J Immunol2006，177，3： | 1 |
| 9 | Epithelioid haemangioendothelioma of the thyroid gland : a case report and review of literature显示文摘 | Siddiqui M T Evans H L Ro J Y | 1998 | Histopathology1998，32，5： | 1 |
| 10 | Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf - 1 via oxidative stress 显示文摘 | Chen J Siddiqui A | 2007 | J Virol2007，81，12： | 1 |
| 11 | Circulating cytokine/inhibitor profilfes reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality显示文摘 | Osuchowski MF Welch K Siddiqui J | 2006 | J Immunol2006，177，3： | 1 |
| 12 | Inflammation, insulin resistance and carotid IMT in first degree relatives of north Indian type 2 diabetic subjects 显示文摘 | Ahmad J Ahmed F Siddiqui MA | 2006 | Diabetes Res ccclin Pract2006，73，： | 1 |
| 13 | The role of serotonin (5-hydroxytryptaminelA and 1B) receptors in prostate cancer cell proliferation显示文摘 | Siddiqui E J Shabbir M Mikhailidis DP | 2006 | J Urol2006，176，41： | 1 |
| 14 | Use of X - ray diffraction in assessing the aging pattern of asphalt fractions 显示文摘 | SIDDIQUI M N ALI M F SHIROKOFF J | 2002 | Fuel2002，81，1： | 1 |
| 15 | Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality显示文摘 | Osuchowski M F Welch K Siddiqui J | | 0，，： | 1 |
| 16 | Urs0de0xyeh01ic acid for the treatment of intrahepatic cholestasis of pregnancy 显示文摘 | Laifer SA Stiller R J Siddiqui DS | 2001 | J Matem Fetal Med2001，10，20： | 1 |
| 17 | Implementation of Rank based Sleep Scheduling(RBSS) Protocol for WSNs in a Fixed Grid Topology显示文摘 | Shehami T Siddiqui A J Abbasi H I | 2013 | Procedia Computer Science2013，19，： | 1 |
| 18 | Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality显示文摘 | Osuchowski MF Welch K Siddiqui J | 2006 | J Immunol2006，177，3： | 1 |
| 19 | Determination of β-glucan ill oats and barly 显示文摘 | Wood P J Paton D Siddiqui L R | 1977 | Cereal Chem1977，54，3： | 1 |
| 20 | Membrane for the control of natural organic matter from surface waters显示文摘 | Siddiqui M Amyg Ruah J | 2000 | Water Research2000，34，13： | 1 |
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