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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 3 | Effectiveness, securityand height restoration on fresh compression fractures - - a comparative prospective study of vertebroplasty and kyphoplasty 显示文摘 | Rollinghoff M Siewe J Zarghooni K | 2009 | Minim Invasive Neurosurg2009，52，56： | 1 |
| 4 | ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR显示文摘 | Kullmann M Gopfert U Siewe B | 2002 | Genes Dev2002，16，23： | 1 |
| 5 | Texture measures for carpet wear assessment显示文摘 | Siew L H Hodgson R M Wood E J | 1988 | IEEE Transactions on Pattern Analysis and Machine Intelligence1988，10，1： | 1 |
| 6 | Effects of degumming and bleaching on 3-MCPD esters formation during physical refining 显示文摘 | RAMLI M R SIEW W L IBRHIM N A | 2011 | Journal of the American Oil Chemists'' Society2011，88，11： | 1 |
| 7 | Low cost removal of disperse dye from aqueous solution using palm ash显示文摘 | TSA M Hasnain LANG Lee Siew ASAARI Faridah A H | 2007 | Dyes and Pigments2007，74，： | 1 |
| 8 | Technological advances in nontraditional orthodontics显示文摘 | Bonnick AM Nalbandian M Siewe MS | 2011 | Dent Clin North Am2011，55，3： | 1 |
| 9 | DNA-based characterisation and classification of forensically important flesh flies ( Diptera: Sarcophagidae ) in Malaysia 显示文摘 | Siew H T Mohammed R I Edah M A | 2010 | Forensic Sci Int2010，199，1： | 1 |
| 10 | In vitro characterization of chitosan - gelatin scaffolds for tissue engineering 显示文摘 | HUANG Y ONYERI S SIEWE M | 2005 | Biomateri- als2005，26，36： | 1 |
| 11 | Do Chinese Trust Chinese? A Study of Chinese Buyers and Sellers in Malaysia显示文摘 | ARMSTRONG W R SIEW M Y | 2001 | Journal of International Marketing2001，9，3： | 1 |
| 12 | TAG composition and solid fat content of palm oil, sunflower oil, and palm kernel olein blends before and after chemical interesterification 显示文摘 | NOORLIDA H M D SUNDRAM K SIEW W L | 2002 | J Am Oil Chem Soc2002，79，： | 1 |
| 13 | Can predicate- argument structures be used for contextual opinion retrieval from blogs? 显示文摘 | Orimaye S O Alhashmi S M Siew E G | 2013 | World Wide Web-Internet and Web Information Systems2013，16，56： | 1 |
| 14 | Effectiveness, security and height restoration on fresh compression fractures--a comparative prospective study of vertebroplasty and kyphoplasty显示文摘 | Rollinghoff M Siewe J Zarghooni K | 2009 | Minim Inva- sire Neurosurg2009，52，56： | 1 |
| 15 | Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery显示文摘 | Billings FT 4th Pretorius M Siew ED | | 0，，06： | 1 |
| 16 | Prognostic nomogram for diffuse large B-cell lymphoma (DLBCL) incorporating the in- ternational prognostic index (IPI) with interim-positron emis- sion tomography (interim-PET) Findings 显示文摘 | Chow A Phillips M Siew T | 2013 | Inter Med J2013，43，： | 1 |
| 17 | Conducted immunity requirements for equipment operational during high voltage network switching operations显示文摘 | Stewart M G Siew W H Walker K F | 2001 | IEE Proceedings-Generation Transmission and Distribution2001，148，5： | 1 |
| 18 | Do Chinese Trust Chinese? A Study of Chinese Buyers and Sellers in Malaysia 显示文摘 | Armstrong W R Siew M Y | 2001 | Journal of International Marketing2001，9，3： | 1 |
| 19 | 显示文摘 | Huang Y Onyeri S Siewe M | 2005 | Biomaterials2005，26，36： | 1 |
| 20 | Effectiveness,security and height restoration on fresh compression fractures:A comparative prospective study of vertebroplasty and kyphoplasty显示文摘 | R(o)llinghoff M Siewe J Zarghooni K | 2009 | Minim Invasive Neurosurg2009，52，56： | 1 |
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