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| 1 | 联合应用伏立康唑和卡泊芬净可有效治疗侵袭性曲霉感染显示文摘背景:联合应用伏立康唑和卡泊芬净作为器官移植患者侵袭性曲霉感染的基础性治疗方法的疗效尚未进行研究。 | Singh N Limaye AP Forrest G 邓妍 | 2006 | 中国处方药2006，5，3： | 28 |
| 2 | 保护层的质和量与镀锌焊接钢丝网水泥的耐久性显示文摘本文首先讨论以混凝土保护层的性能推测砂浆保护层的耐久性是否可靠.然后介绍讨论100多个钢丝网水泥试件在荷载与氯化钠溶液(或酸性溶液)腐蚀共同作用下的长期性能实验结果;并结合工程实际,说明在保证质量前提下,保护层厚为5mm的镀锌焊接钢丝网水泥具有良好的耐久性. | 熊光晶 GSINGH | 1998 | 水利学报1998，29，7： | 16 |
| 3 | Antihyperglycemic activity,antihyperlipedemic activity,haematological effects and histopathological analysis of Sapindus mukorossi Gaerten fruits in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antihyperglycemic and antihyperlipidemie properties of hydroalcoholic extract of fruits of Sapindus mukorossi Caerlen and its beneficial effect on haeniatological parameters with histopathological analysis in streptpzotocin induced diabetic rats.Methods:Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and standard drug glybenclamide(0.5 mg/kg body weight) were administered to diabetic rats.Effect of extract on hyperglycemia,hyperlipidemia and hematological parameters was studied in diabetic rats.Histopathological changes in diabetic rat pancreas were also observed after extract and glybenclamide treatment.Results:Daily oral administration of Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and glybenclamide for 20 days showed beneficial effects on blood glucose level(P<0.01) and lipid level.The extract has a favorable effect on the histopathological changes of the pancreas in streptozotocin induced diabetes.Conclusions: These findings reveal that the hydroalcoholic extract of Sapindus mukorossi fruits extract possesses antihyperglycemic and antihyperlipidemie properties.In addition.the extract can prevent various complications of diabetes and improve some haeniatological parameters. | Neeraj Verma G Amresh P K Sahu Neelam Mishra Anil P Singh Ch V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 14 |
| 4 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 5 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 6 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 7 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 8 | The DSSAT cropping system model显示文摘 | J.W Jones G Hoogenboom C.H Porter K.J Boote W.D Batchelor L.A Hunt P.W Wilkens U Singh A.J Gijsman J.T Ritchie | 2002 | European Journal of Agronomy2002，，3： | 4 |
| 9 | 创伤性寰枢椎滑脱伴移位型齿状突骨折:采用“关节重塑”技术实现后路完全复位显示文摘寰枢椎脱位(atlantocaxial dislocation,AAD)是在先天性和创伤性情况下,寰枢关节常见的一种不正常关系,寰枢椎滑脱(atlantoaxial spondyloptosis,AAS)是指寰椎侧块小关节面完全移位,两个关节面之间无接触,是寰枢椎不稳定的一种罕见表现,属于最严重的寰枢椎脱位之一。由于寰枢关节面交锁,传统的后路手术方式或单纯凭借颅骨牵引均无法使寰枢椎完全复位。“关节操作”技术最初由Goel等提出,通过术中C1~C2撑开及进行寰枢关节操作实现颅颈交界区的重新对位。但单独使用该技术并不能达到关节复位,因此需要联合关节重塑技术(通过在C1关节面前下方边缘及C2关节面钻孔以辅助骨刀插入,获得撑开及部分复位),使寰枢关节复位到正常的解剖位置。作者对1例创伤性AAS伴移位型齿状突骨折患儿采取单纯后路手术,通过“关节操作”和“关节重塑”技术实现完全复位,效果良好。 | kumar a varshney g singh pk 葛苏 马向阳 | 2018 | 中国骨科临床与基础研究杂志2018，10，1： | 3 |
| 10 | Frameworks of Non-Orthogonal Multiple Access Techniques in Cognitive Radio Communication Systems显示文摘Recently,the increasing demand of radio spectrum for the next generation communication systems due to the explosive growth of applications appetite for bandwidths has led to the problem of spectrum scarcity.The potential approaches among the proposed solutions to resolve this issue are well explored cognitive radio(CR)technology and recently introduced non-orthogonal multiple access(NOMA)techniques.Both the techniques are employed for efficient spectrum utilization and assure the significant improvement in the spectral efficiency.Further,the significant improvement in spectral efficiency can be achieved by combining both the techniques.Since the CR is well-explored technique as compared to that of the NOMA in the field of communication,therefore it is worth and wise to implement this technique over the CR.In this article,we have presented the frameworks of NOMA implementation over CR as well as the feasibility of proposed frameworks.Further,the differences between proposed CR-NOMA and conventional CR frameworks are discussed.Finally,the potential issues regarding the implementation of CR-NOMA are explored. | Prabhat Thakur Alok Kumar S Pandit G Singh S N Satashia | 2019 | China Communications2019，16，6： | 3 |
| 11 | Cytotoxic and antioxidant activity of selected marine sponges显示文摘 | K Chairman AJA Ranjit Singh G Alagumuthu | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 3 |
| 12 | Development of a Direct Competitive Enzyme-Linked Immunosorbent Assay for the Detection of Fluoroquinolone Residues in Shrimp显示文摘 | Sheryl A. Tittlemier Jean-Marc Gélinas Guy Dufresne Mehul Haria Jessica Querry Chantal Cleroux Cathie Ménard Philippe Delahaut Gurmit Singh Nathalie Fischer-Durand Samuel Benrejeb Godefroy | 2008 | Food Analytical Methods2008，，1： | 2 |
| 13 | Genotypic variation in nitrogen use efficiency in medium- and long-duration rice显示文摘 | U Singh J.K Ladha E.G Castillo G Punzalan A Tirol-Padre M Duqueza | 1998 | Field Crops Research1998，，1： | 2 |
| 14 | The DSSAT cropping system model显示文摘 | J.W Jones G Hoogenboom C.H Porter K.J Boote W.D Batchelor L.A Hunt P.W Wilkens U Singh A.J Gijsman J.T Ritchie | 2002 | European Journal of Agronomy2002，，3： | 2 |
| 15 | Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches. | Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 16 | Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene显示文摘 | Singh R Nielsen AL Marianne G | 2003 | Genomics2003，82，： | 2 |
| 17 | Microstructrual and aqueous corrosion aspects of laser-surface-melted type 304 SS plasma-coated mild steel显示文摘 | Pukar M G Dayal R K Singh Raman R K | 1994 | Journal of Materials Engineering and Performance1994，，3： | 2 |
| 18 | Pulmonary alveolar microlithiasis: an interesting case report with systematic review of Indian literature显示文摘肺的牙槽的 microlithiasis 是 microliths 的 intra 牙槽的存在描绘的稀罕疾病。这研究报导肺的牙槽的 microlithiasis 的一个有趣的案例并且提供从印度报导的案例的系统的评论。与咳嗽,喘息,胸疼痛,和阵发性的喘息的历史介绍五个月的 23 岁的女性。肺的功能测试表明了一个妨碍的模式,并且胸 X 射线显示出主要包含两个肺的中间、更低的地区的好 micronodular 暗。Transbronchial 肺活体检视揭示了诊断。她对吸入的类固醇治疗作出回应很好。文学的系统的评论被执行并且鉴别肺的牙槽的 microlithiasis 的 73 个案例从印度报导了。病人的平均数(SD ) 年龄是 28.8 (14.9 ) 年,与几乎相等的 male:female 比率。许多病人在表示是无征状的。呼吸急促和咳嗽是最普通的症状,并且疾病进行了进与英国管 pulmonale 联系的呼吸失败。大约三分之一个个案例开始被误诊并且对待同样肺的肺结核。额外肺的表明和 comorbidities 在我们的系列也是明显的。这系统的评论帮助决定肺的牙槽的 microlithiasis 的流行病学、临床的特征。进一步的研究被需要阐明 etiopathogenesis,诊断,和治疗学的选择,它在为肺的牙槽的 microlithiasis 开发并且识别 costeffective 治疗是有益的。 | Nidhya Ganesan Marie Moses Ambroise Anita Ramdas King Herald Kisku Kulwant Singh Renu G' Boy Varghese | 2015 | Frontiers of Medicine2015，9，2： | 2 |
| 19 | Primary small cell neuroendocrine carcinoma of urinary bladder: an uncommon entity to be recognized显示文摘 | Nabi G Singh I Ansari MS | 2001 | Int Urol Nephrol2001，33，： | 2 |
| 20 | Circadian heart rate and blood pressure variability considered for research and patient care 显示文摘 | Singh RB Corne lissen G Weydahl A | 2003 | Int J Cardiol2003，87，1： | 1 |
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