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| 1 | Changes of the cytokine profile in inflammatory bowel diseases显示文摘Cytokines are indispensable signals of the mucosaassociated immune system for maintaining normal gut homeostasis.An imbalance of their profile in favour of inflammation initiation may lead to disease states,such as that is observed in inflammatory bowel diseases(IBD).Although Crohn's disease(CD) is often described as a prototype of T-helper 1-type diseases,and ulcerative colitis(UC) is traditionally viewed as a T-helper 2-mediated condition,the classic paradigm,which categorises cytokines into pro-and anti-inflammatory groups,has recently been changed.The inflammation regulatory pathways may not be mutually exclusive as individual cytokines can have diverse and even opposing functions in various clinical and immunological settings.None the less there are many common immunological responses in IBD that are mediated by cytokines.Although they regulate and influence the development,course and recurrence of the inflammatory process,the concrete pathogenic role of these small signaling molecules is sometimes not unambiguous in the subtypes of the disease.Our aim is to review the current information about pro-and anti-inflammatory effects of traditionally studied and recently discovered cytokines in the pathogenesis of UC and CD.The better understanding of their production and functional activity may lead to the development of new therapeutic modalities. | Gyrgyi Mzes Béla Molnár Zsolt Tulassay Ferenc Sipos | 2012 | World Journal of Gastroenterology2012，18，41： | 16 |
| 2 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 3 | Regulatory T cells in inflammatory bowel diseases and colorectal cancer显示文摘Regulatory T cells(T regs) are key elements in immunological self-tolerance.The number of T regs may alter in both peripheral blood and in colonic mucosa during pathological circumstances.The local cellular,microbiological and cytokine milieu affect immunophenotype and function of T regs.Forkhead box P3+ T regs function shows altered properties in inflammatory bowel diseases(IBDs).This alteration of T regs function can furthermore be observed between Crohn's disease and ulcerative colitis,which may have both clinical and therapeutical consequences.Chronic mucosal inflammation may also influence T regs function,which together with the intestinal bacterial flora seem to have a supporting role in colitis-associated colorectal carcinogenesis.T regs have a crucial role in the immunoevasion of cancer cells in sporadic colorectal cancer.Furthermore,their number and phenotype correlate closely with the clinical outcome of the disease,even if their contribution to carcinogenesis has previously been controversial.Despite knowledge of the clinical relationship between IBD and colitis-associated colon cancer,and the growing number of immunological aspects encompassing sporadic colorectal carcinogenesis,the molecular and cellular links amongst T regs,regulation of the inflammation,and cancer development are still not well understood.In this paper,we aimed to review the current data surrounding the role of T regs in the pathogenesis of IBD,colitis-associated colon cancer and sporadic colorectal cancer. | Gyrgyi Mzes Béla Molnár Ferenc Sipos | 2012 | World Journal of Gastroenterology2012，18，40： | 7 |
| 4 | Serrated pathway:Alternative route to colorectal cancer显示文摘Serrated polyps have been an area of intense focus for gastroenterologists over the past several years. Contrary to what was thought before,a growing body of literature indicates that these polyps can be precursors of colorectal cancer(CRC).Most of these lesions, particularly those in the proximal colon,have so far been under-recognized and missed during colonoscopy,qualifying these lesions to be the main cause of interval cancers.It is estimated that 10%-20%of CRCs evolve through this alternative,serrated pathway, with a distinct genetic and epigenetic profile.Aberrant DNA methylation plays a central role in the development of this CRC subtype.This characteristic molecular background is reflected in a unique pathological and clinical manifestation different from cancers arising via the traditional pathway.In this review we would like to highlight morphological,molecular and clinical features of this emerging pathway that are essential for gastroenterologists and may influence their everyday practice. | rpád V Patai Béla Molnár Zsolt Tulassay Ferenc Sipos | 2013 | World Journal of Gastroenterology2013，19，5： | 4 |
| 5 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 6 | Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis显示文摘 | Ferenc Sipos Orsolya Galamb László Herszényi Béla Molnár Norbert Solymosi Tamás Zágoni Lajos Berczi Zsolt Tulassay | 2008 | Scandinavian Journal of Gastroenterology2008，，3： | 2 |
| 7 | Effect of primer mismatch, annealing temperature and PCR cycle number on 16S rRNA gene-targetting bacteri- al community analysis 显示文摘 | SIPOS R SZIKELY AJ PALATINSZKY M | 2007 | FEMS Microbiol Ecol2007，60，2： | 1 |
| 8 | DGGE and T-RFLP analysis of bacterial succession during mushroo compost production and sequenceaided T RFLP profile of mature compost显示文摘 | Sz6kely A J Sipos R Berta B | 2009 | Microbial Ecology2009，57，3： | 1 |
| 9 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 10 | Patient satisfaction and post- operative pain with different postoperative therapy regimens after standardized cataract surgery:a randomizedintraindivid- ual comparison显示文摘 | Sipos E Stifter E Menapace R | 2011 | Int Ophthalmol2011，31，6： | 1 |
| 11 | Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection显示文摘 | G. Sipos K. Altdorfer é. Pongor L. P. Chen E. Fehér | 2006 | Digestive Diseases and Sciences2006，，10： | 1 |
| 12 | Inhibition of tumor angiogenesis显示文摘 | SIPOS E P TAMARGO R T WEINGART J D | 1994 | Ann N Y Acad Sci1994，732，： | 1 |
| 13 | 查看详情显示文摘 | Sipos L Som A Faust R | | 0，，： | 1 |
| 14 | DGGE and T-RFLP analysis of bacterial succession during mushroom compost production and sequence-aided T-RFLP profile of mature compost 显示文摘 | Szekely AJ Sipos R Berta B Vajna B Hajdu C M(lrialigeti K | 2009 | Microbial Ecology2009，57，： | 1 |
| 15 | The efficient calculation of neurosurgically relevant volumes from computed toraographic scans using Cavalieri~ Di- rect Estimator显示文摘 | Clattcrbuck R E Sipos E P | 1997 | Neurosurgery1997，40，2： | 1 |
| 16 | Sustained nonver- tebral fragility fracture risk reduction after discontinuation of teriparatide treatment 显示文摘 | Prince R Sipos A Hossain A | 2005 | J Bone Miner Res2005，20，： | 1 |
| 17 | Furandicarboxylic acid(FDCA)a versatile building block for a very interesting class of polyesters显示文摘 | De J E Dam M R Sipos L | 2012 | Acs Symposium2012，1105，13： | 1 |
| 18 | DGGE and T-RFLP analysis of bacterial succession during mushroom compost production and sequence-aided T-RFLP profile of mature compost 显示文摘 | SZEKELY A J SIPOS R BERTA B | 2009 | Microbial Ecology2009，57，： | 1 |
| 19 | Peroxisome proliferator-activated receptor gamma is highly expressed in pancreatic cancer and is assoelated with shorter overall survival times显示文摘 | Kristiansen G Jacob J Buckendahl A C Grutzmann R Alldinger Ⅰ Sipos B | 2006 | Clin Cancer Res2006，12，： | 1 |
| 20 | Spectroscopy of Concentration Sodium Aluminate Solutions显示文摘 | Waltling H R Sipos P M | 1998 | Applied Spectroscopy1998，52，2： | 1 |
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